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4DJO

Crystal Structure of wild-type HIV-1 Protease in Complex with MKP56

Summary for 4DJO
Entry DOI10.2210/pdb4djo/pdb
Related4DJP 4DJQ 4DJR
DescriptorPol polyprotein, 2-[(dichloroacetyl)amino]ethyl [(2S,3R)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-phenylbutan-2-yl]carbamate, GLYCEROL, ... (6 entities in total)
Functional Keywordshiv-1 protease, drug resistance, drug design, protease inhibitors, aids, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22591.23
Authors
Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2012-02-02, release date: 2012-08-01, Last modification date: 2024-02-28)
Primary citationParai, M.K.,Huggins, D.J.,Cao, H.,Nalam, M.N.,Ali, A.,Schiffer, C.A.,Tidor, B.,Rana, T.M.
Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.
J.Med.Chem., 55:6328-6341, 2012
Cited by
PubMed: 22708897
DOI: 10.1021/jm300238h
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.78 Å)
Structure validation

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