1T7J

crystal structure of inhibitor amprenavir in complex with a multi-drug resistant variant of HIV-1 protease (L63P/V82T/I84V)

Summary for 1T7J

• Entry DOI: 10.2210/pdb1t7j/pdb
• Related: 1F7A 1T3R
• Descriptor: Pol Polyprotein, ACETATE ION, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, ... (4 entities in total)
• Functional Keywords: hiv-1 protease, drug resitance, thermodynamics, substrate envelope, hydrolase
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P35963
• Total number of polymer chains: 2
• Total formula weight: 22405.30

Authors

King, N.M.,Prabu-Jeyabalan, M.,Nalivaika, E.A.,Wigerinck, P.B.T.P.,De Bethune, M.-P.,Schiffer, C.A. (deposition date: 2004-05-10, release date: 2005-05-10, Last modification date: 2023-08-23)

• Primary citation: Surleraux, D.L.N.G.,Tahri, A.,Verschueren, W.G.,Pille, G.M.E.,de Kock, H.A.,Jonckers, T.H.M.,Peeters, A.,De Meyer, S.,Azijn, H.,Pauwels, R.,de Bethune, M.-P.,King, N.M.,Prabu-Jeyabalan, M.,Schiffer, C.A.,Wigerinck, P.B.T.P.; Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor; J.Med.Chem., 48:1813-1822, 2005; PubMed: 15771427; DOI: 10.1021/jm049560p

Experimental method

X-RAY DIFFRACTION (2.2 Å)