1T7J
crystal structure of inhibitor amprenavir in complex with a multi-drug resistant variant of HIV-1 protease (L63P/V82T/I84V)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Pol Polyprotein | polymer | 99 | 10831.8 | 2 | UniProt (P35963) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | C, D, E, G (A, B) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 3 | F (A) | {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | non-polymer | 505.6 | 1 | Chemie (478) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 58 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P35963)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 63 | engineered mutation |
| Arg 14 | Lys 70 | engineered mutation |
| Thr 82 | Val 138 | engineered mutation |
| Val 84 | Ile 140 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21663.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 741.8 | |
| All* | Total formula weight | 22405.3 |
