6CVR
| Human Aprataxin (Aptx) S242N bound to RNA-DNA, AMP and Zn product complex | 分子名称: | ADENOSINE MONOPHOSPHATE, Aprataxin, DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ... | 著者 | Schellenberg, M.J, Tumbale, P.S, Williams, R.S. | 登録日 | 2018-03-28 | 公開日 | 2018-07-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease. EMBO J., 37, 2018
|
|
6CVQ
| Human Aprataxin (Aptx) H201Q bound to RNA-DNA, AMP and Zn product complex | 分子名称: | ADENOSINE MONOPHOSPHATE, Aprataxin, BETA-MERCAPTOETHANOL, ... | 著者 | Schellenberg, M.J, Tumbale, P.S, Williams, R.S. | 登録日 | 2018-03-28 | 公開日 | 2018-07-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease. EMBO J., 37, 2018
|
|
6CVO
| Human Aprataxin (Aptx) bound to nicked RNA-DNA, AMP and Zn product complex | 分子名称: | ADENOSINE MONOPHOSPHATE, Aprataxin, BETA-MERCAPTOETHANOL, ... | 著者 | Schellenberg, M.J, Tumbale, P.P, Williams, R.S. | 登録日 | 2018-03-28 | 公開日 | 2018-08-29 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease. EMBO J., 37, 2018
|
|
4NDH
| Human Aprataxin (Aptx) bound to DNA, AMP, and Zn - product complex | 分子名称: | 5'-D(P*GP*TP*TP*CP*TP*AP*GP*AP*AP*C)-3', ADENOSINE MONOPHOSPHATE, Aprataxin, ... | 著者 | Schellenberg, M.J, Tumbale, P.S, Williams, R.S. | 登録日 | 2013-10-26 | 公開日 | 2013-12-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.848 Å) | 主引用文献 | Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. Nature, 506, 2013
|
|
4NDI
| Human Aprataxin (Aptx) AOA1 variant K197Q bound to RNA-DNA, AMP, and Zn - product complex | 分子名称: | 5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3', 5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3', ADENOSINE MONOPHOSPHATE, ... | 著者 | Schellenberg, M.J, Tumbale, P.S, Williams, R.S. | 登録日 | 2013-10-26 | 公開日 | 2013-12-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. Nature, 506, 2013
|
|
4NDF
| Human Aprataxin (Aptx) bound to RNA-DNA, AMP, and Zn - product complex | 分子名称: | 5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3', 5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3', ADENOSINE MONOPHOSPHATE, ... | 著者 | Schellenberg, M.J, Tumbale, P.S, Williams, R.S. | 登録日 | 2013-10-26 | 公開日 | 2013-12-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.944 Å) | 主引用文献 | Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. Nature, 506, 2013
|
|
4NDG
| Human Aprataxin (Aptx) bound to RNA-DNA and Zn - adenosine vanadate transition state mimic complex | 分子名称: | 5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3', 5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3', Aprataxin, ... | 著者 | Schellenberg, M.J, Tumbale, P.S, Williams, R.S. | 登録日 | 2013-10-26 | 公開日 | 2013-12-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.541 Å) | 主引用文献 | Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. Nature, 506, 2013
|
|
6P0B
| Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, dideoxy Terminated DNA nick with 200 mM Mg2+ | 分子名称: | ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... | 著者 | Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. | 登録日 | 2019-05-16 | 公開日 | 2019-12-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.203 Å) | 主引用文献 | Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
|
|
6P0A
| Human DNA Ligase 1 Bound to an Adenylated, dideoxy Terminated DNA nick with 2 mM Mg2+ | 分子名称: | ADENOSINE MONOPHOSPHATE, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | 著者 | Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. | 登録日 | 2019-05-16 | 公開日 | 2019-12-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
|
|
6P0D
| Human DNA Ligase 1 (E346A/E592A) Bound to an Adenylated, hydroxyl terminated DNA nick | 分子名称: | ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... | 著者 | Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. | 登録日 | 2019-05-16 | 公開日 | 2019-12-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
|
|
6P0C
| Human DNA Ligase 1 Bound to an Adenylated, hydroxyl terminated DNA nick in EDTA | 分子名称: | ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... | 著者 | Schellenberg, M.J, Tumbale, P.S, Riccio, A.A, Williams, R.S. | 登録日 | 2019-05-16 | 公開日 | 2019-12-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
|
|
6P09
| Human DNA Ligase 1 Bound to an Adenylated, dideoxy Terminated DNA nick with 200 mM Mg2+ | 分子名称: | ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ... | 著者 | Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. | 登録日 | 2019-05-16 | 公開日 | 2019-12-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.052 Å) | 主引用文献 | Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
|
|
6P0E
| Human DNA Ligase 1 (E346A,E592A) bound to adenylated DNA containing an 8-oxo guanine:adenine base-pair | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. | 登録日 | 2019-05-16 | 公開日 | 2019-12-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
|
|
6Q00
| TDP2 UBA Domain Bound to Ubiquitin at 0.85 Angstroms Resolution, Crystal Form 1 | 分子名称: | POTASSIUM ION, Tyrosyl-DNA phosphodiesterase 2, Ubiquitin | 著者 | Schellenberg, M.J, Krahn, J.M, Williams, R.S. | 登録日 | 2019-08-01 | 公開日 | 2020-04-29 | 最終更新日 | 2020-06-24 | 実験手法 | X-RAY DIFFRACTION (0.85 Å) | 主引用文献 | Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2. Nucleic Acids Res., 48, 2020
|
|
6Q01
| TDP2 UBA Domain Bound to Ubiquitin at 0.85 Angstroms Resolution, Crystal Form 2 | 分子名称: | 1,2-ETHANEDIOL, BENZOIC ACID, MAGNESIUM ION, ... | 著者 | Schellenberg, M.J, Krahn, J.M, Williams, R.S. | 登録日 | 2019-08-01 | 公開日 | 2020-04-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (0.851 Å) | 主引用文献 | Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2. Nucleic Acids Res., 48, 2020
|
|
6Q1V
| Human DNA Ligase 1 (E592R) Bound to an Adenylated, hydroxyl terminated DNA nick | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ADENOSINE MONOPHOSPHATE, ... | 著者 | Schellenberg, M.J, Williams, R.S, Tumbale, P.S, Riccio, A.A. | 登録日 | 2019-08-06 | 公開日 | 2019-12-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Two-tiered enforcement of high-fidelity DNA ligation. Nat Commun, 10, 2019
|
|
4GZ0
| |
4GZ1
| |
4GYZ
| Mus Musculus Tdp2 Bound to dAMP and Mg2+ | 分子名称: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Schellenberg, M.J, Williams, R.S. | 登録日 | 2012-09-05 | 公開日 | 2012-10-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.556 Å) | 主引用文献 | Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2. Nat.Struct.Mol.Biol., 19, 2012
|
|
4GZ2
| Mus Musculus Tdp2 excluded ssDNA complex | 分子名称: | DNA (5'-D(*CP*AP*TP*CP*CP*GP*AP*AP*TP*TP*CP*G)-3'), FORMIC ACID, MAGNESIUM ION, ... | 著者 | Schellenberg, M.J, Williams, R.S. | 登録日 | 2012-09-05 | 公開日 | 2012-10-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2. Nat.Struct.Mol.Biol., 19, 2012
|
|
4J5S
| TARG1 (C6orf130), Terminal ADP-ribose Glycohydrolase 1 ADP-ribose complex | 分子名称: | 1,2-ETHANEDIOL, 1,3,2-DIOXABOROLAN-2-OL, BORATE ION, ... | 著者 | Schellenberg, M.J, Appel, C.D, Krahn, J, Williams, R.S. | 登録日 | 2013-02-09 | 公開日 | 2013-03-27 | 最終更新日 | 2013-07-03 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. Embo J., 32, 2013
|
|
4JKB
| Open and closed forms of V1788D human PRP8 RNase H-like domain with bound Mg ion | 分子名称: | CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... | 著者 | Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. | 登録日 | 2013-03-09 | 公開日 | 2013-05-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
|
|
4J5Q
| TARG1 (C6orf130), Terminal ADP-ribose Glycohydrolase 1, apo structure | 分子名称: | O-acetyl-ADP-ribose deacetylase 1 | 著者 | Schellenberg, M.J, Appel, C.D, Krahn, J, Williams, R.S. | 登録日 | 2013-02-09 | 公開日 | 2013-03-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. Embo J., 32, 2013
|
|
4JK9
| Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Co ion | 分子名称: | CHLORIDE ION, COBALT (II) ION, GLYCEROL, ... | 著者 | Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. | 登録日 | 2013-03-09 | 公開日 | 2013-05-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
|
|
4JKH
| Open and closed forms of D1781E human PRP8 RNase H-like domain with bound Mg ion | 分子名称: | CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... | 著者 | Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. | 登録日 | 2013-03-09 | 公開日 | 2013-05-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
|
|