4NDH
Human Aprataxin (Aptx) bound to DNA, AMP, and Zn - product complex
Summary for 4NDH
Entry DOI | 10.2210/pdb4ndh/pdb |
Related | 3SZQ 4NDF 4NDG 4NDI |
Descriptor | Aprataxin, 5'-D(P*GP*TP*TP*CP*TP*AP*GP*AP*AP*C)-3', ADENOSINE MONOPHOSPHATE, ... (5 entities in total) |
Functional Keywords | protein-dna complex, dna repair, 5'-dna end processing, histidine triad domain, hit domain, zinc finger, 5'-dna end recognition, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm. Isoform 12: Cytoplasm: Q7Z2E3 |
Total number of polymer chains | 6 |
Total formula weight | 55520.84 |
Authors | Schellenberg, M.J.,Tumbale, P.S.,Williams, R.S. (deposition date: 2013-10-26, release date: 2013-12-18, Last modification date: 2023-09-20) |
Primary citation | Tumbale, P.,Williams, J.S.,Schellenberg, M.J.,Kunkel, T.A.,Williams, R.S. Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. Nature, 506:111-115, 2013 Cited by PubMed: 24362567DOI: 10.1038/nature12824 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.848 Å) |
Structure validation
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