6CVO

Human Aprataxin (Aptx) bound to nicked RNA-DNA, AMP and Zn product complex

Summary for 6CVO

• Entry DOI: 10.2210/pdb6cvo/pdb
• Related: 4NDF
• Descriptor: Aprataxin, DNA/RNA (5'-R(P*G)-D(P*TP*TP*CP*TP*AP*TP*AP*TP*AP*TP*AP*GP*AP*AP*CP*GP*CP*TP*GP*TP*T)-3'), DNA (5'-D(*AP*AP*CP*AP*GP*C)-3'), ... (7 entities in total)
• Functional Keywords: protein-dna complex, dna repair, 5'-dna end processing, histidine triad domain, hit domain, zinc-finger, 5'-dna end recognition, hydrolase-dna-rna complex, hydrolase/dna/rna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 60650.28

Authors

Schellenberg, M.J.,Tumbale, P.P.,Williams, R.S. (deposition date: 2018-03-28, release date: 2018-08-29, Last modification date: 2023-10-04)

• Primary citation: Tumbale, P.,Schellenberg, M.J.,Mueller, G.A.,Fairweather, E.,Watson, M.,Little, J.N.,Krahn, J.,Waddell, I.,London, R.E.,Williams, R.S.; Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.; EMBO J., 37:-, 2018; PubMed: 29934293; DOI: 10.15252/embj.201798875

Experimental method

X-RAY DIFFRACTION (2.4 Å)