6CVO

Human Aprataxin (Aptx) bound to nicked RNA-DNA, AMP and Zn product complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	Aprataxin	polymer	182	21259.8	2	UniProt (Q7Z2E3) Pfam (PF11969) Pfam (PF16278)	Homo sapiens (Human)	Forkhead-associated domain histidine triad-like protein,FHA-HIT
2	B, D (D, G)	DNA/RNA (5'-R(P*G)-D(P*TP*TP*CP*TP*AP*TP*AP*TP*AP*TP*AP*GP*AP*AP*CP*GP*CP*TP*GP*TP*T)-3')	polymer	22	6772.4	2		Homo sapiens
3	E, F (E, H)	DNA (5'-D(*AP*AP*CP*AP*GP*C)-3')	polymer	6	1802.2	2		Homo sapiens
4	G, J (A, B)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP)
5	H, K (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	I, L (A, B)	BETA-MERCAPTOETHANOL	non-polymer		78.1	2	Chemie (BME)
7	M, N, O, P, Q... (A, D, B, G, E...)	water	water		18.0	404	Chemie (HOH)

Sequence modifications

A, B: 165 - 342 (UniProt: Q7Z2E3)

PDB	External Database	Details
Gly 161	-	expression tag
Ser 162	-	expression tag
His 163	-	expression tag
Met 164	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	59668.8
Non-Polymers*	Number of molecules	6
	Total formula weight	981.5
All*	Total formula weight	60650.3

*Water molecules are not included.