4JKB
Open and closed forms of V1788D human PRP8 RNase H-like domain with bound Mg ion
Summary for 4JKB
| Entry DOI | 10.2210/pdb4jkb/pdb |
| Related | 3ENB 4JK7 4JK8 4JK9 4JKA 4JKC 4JKD 4JKE 4JKF 4JKG 4JKH |
| Descriptor | Pre-mRNA-processing-splicing factor 8, GLYCEROL, CHLORIDE ION, ... (5 entities in total) |
| Functional Keywords | metalloprotein, conformational change, rna binding protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus speckle (By similarity): Q6P2Q9 |
| Total number of polymer chains | 2 |
| Total formula weight | 51611.64 |
| Authors | Schellenberg, M.J.,Wu, T.,Ritchie, D.B.,Atta, K.A.,MacMillan, A.M. (deposition date: 2013-03-09, release date: 2013-05-22, Last modification date: 2023-09-20) |
| Primary citation | Schellenberg, M.J.,Wu, T.,Ritchie, D.B.,Fica, S.,Staley, J.P.,Atta, K.A.,Lapointe, P.,Macmillan, A.M. A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20:728-734, 2013 Cited by PubMed: 23686287DOI: 10.1038/nsmb.2556 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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