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PDB: 70 results

5MP7
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Crystal structure of phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis
Descriptor: ACETATE ION, Ribose-phosphate pyrophosphokinase
Authors:Donini, S, Garavaglia, S, Ferraris, D.M, Miggiano, R, Mori, S, Shibayama, K, Rizzi, M.
Deposit date:2016-12-16
Release date:2017-04-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Biochemical and structural investigations on phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis.
PLoS ONE, 12, 2017
6TGW
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Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with a selective inhibitor
Descriptor: Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, methyl 5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylate
Authors:Garavaglia, S, Rizzi, M.
Deposit date:2019-11-18
Release date:2021-06-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells.
Commun Biol, 4, 2021
5HKI
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Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with Fe(III) dicitrate
Descriptor: Iron(III) dicitrate, Orotate phosphoribosyltransferase
Authors:Donini, S, Ferraris, D.M, Bolognesi, G, Rizzi, M.
Deposit date:2016-01-14
Release date:2017-01-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis.
Sci Rep, 7, 2017
6T3E
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Structure of Thermococcus litoralis Delta(1)-pyrroline-2-carboxylate reductase in complex with NADH and L-proline
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, DELTA1-pyrroline-2-carboxylate reductase, PROLINE
Authors:Ferraris, D.M, Miggiano, R, Ferrario, E, Rizzi, M.
Deposit date:2019-10-10
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Thermococcus litoralis Delta1-pyrroline-2-carboxylate reductase in complex with NADH and L-proline.
Acta Crystallogr D Struct Biol, 76, 2020
5HKF
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Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with 5-phospho-alpha-D-ribosyl 1-diphosphate (PRPP)
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Orotate phosphoribosyltransferase
Authors:Donini, S, Ferraris, D.M, Bolognesi, G, Rizzi, M.
Deposit date:2016-01-14
Release date:2017-01-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis.
Sci Rep, 7, 2017
5HKL
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Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with inorganic phosphate
Descriptor: Orotate phosphoribosyltransferase, PHOSPHATE ION
Authors:Donini, S, Bolognesi, G, Rizzi, M.
Deposit date:2016-01-14
Release date:2017-01-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis.
Sci Rep, 7, 2017
7QPO
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Crystal structure of human trans-3-Hydroxy-L-proline dehydratase
Descriptor: Trans-3-hydroxy-L-proline dehydratase
Authors:Ferrario, E, Miggiano, R, Rizzi, M, Ferraris, D.M.
Deposit date:2022-01-05
Release date:2022-08-17
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:The integration of AlphaFold-predicted and crystal structures of human trans -3-hydroxy-l-proline dehydratase reveals a regulatory catalytic mechanism.
Comput Struct Biotechnol J, 20, 2022
2WM1
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The crystal structure of human alpha-amino-beta-carboxymuconate- epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis
Descriptor: 1,3-DIHYDROXYACETONEPHOSPHATE, 2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE, GLYCEROL, ...
Authors:Garavaglia, S, Perozzi, S, Galeazzi, L, Raffaelli, N, Rizzi, M.
Deposit date:2009-06-29
Release date:2009-11-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:The Crystal Structure of Human Alpha-Amino-Beta-Carboxymuconate-Epsilon-Semialdehyde Decarboxylase in Complex with 1,3-Dihydroxyacetonephosphate Suggests a Regulatory Link between Nad Synthesis and Glycolysis
FEBS J., 276, 2009
3ZUK
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ZINC METALLOPROTEASE ZMP1 IN COMPLEX WITH INHIBITOR
Descriptor: 2,2',2''-NITRILOTRIETHANOL, ACETATE ION, CALCIUM ION, ...
Authors:Ferraris, D.M, Sbardella, D, Petrera, A, Marini, S, Amstutz, B, Coletta, M, Sander, P, Rizzi, M.
Deposit date:2011-07-19
Release date:2011-08-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Mycobacterium Tuberculosis Zinc-Dependent Metalloprotease-1 (Zmp1), a Metalloprotease Involved in Pathogenicity.
J.Biol.Chem., 286, 2011
3ZQJ
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Mycobacterium tuberculosis UvrA
Descriptor: UVRABC SYSTEM PROTEIN A, ZINC ION
Authors:Rossi, F, Khanduja, J.S, Bortoluzzi, A, Houghton, J, Sander, P, Guthlein, C, Davis, E.O, Springer, B, Bottger, E.C, Relini, A, Penco, A, Muniyappa, K, Rizzi, M.
Deposit date:2011-06-09
Release date:2011-06-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The Biological and Structural Characterization of Mycobacterium Tuberculosis Uvra Provides Novel Insights Into its Mechanism of Action
Nucleic Acids Res., 39, 2011
4LVQ
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Crystal structure of the M. tuberculosis phosphate binding protein PstS3
Descriptor: PHOSPHATE ION, Phosphate-binding protein PstS 3
Authors:Ferraris, D.M, Rizzi, M.
Deposit date:2013-07-26
Release date:2014-03-26
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Mycobacterium tuberculosis phosphate binding protein PstS3.
Proteins, 82, 2014
2HUI
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BU of 2hui by Molmil
Crystal structure of Aedes aegypti alanine glyoxylate aminotransferase in complex with glyoxylic acid
Descriptor: Alanine glyoxylate aminotransferase, GLYOXYLIC ACID
Authors:Han, Q, Robinson, H, Gao, Y.G, Vogelaar, N, Wilson, S.R, Rizzi, M, Li, J.
Deposit date:2006-07-26
Release date:2006-09-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structures of Aedes aegypti Alanine Glyoxylate Aminotransferase.
J.Biol.Chem., 281, 2006
2HUU
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Crystal structure of Aedes aegypti alanine glyoxylate aminotransferase in complex with alanine
Descriptor: 1-BUTANOL, ALANINE, Alanine glyoxylate aminotransferase
Authors:Han, Q, Robinson, H, Gao, Y.G, Vogelaar, N, Wilson, S.R, Rizzi, M, Li, J.
Deposit date:2006-07-27
Release date:2006-09-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Aedes aegypti Alanine Glyoxylate Aminotransferase.
J.Biol.Chem., 281, 2006
2HUF
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BU of 2huf by Molmil
Crystal structure of Aedes aegypti alanine glyoxylate aminotransferase
Descriptor: 1-BUTANOL, Alanine glyoxylate aminotransferase
Authors:Han, Q, Robinson, H, Gao, Y.G, Vogelaar, N, Wilson, S.R, Rizzi, M, Li, J.
Deposit date:2006-07-26
Release date:2006-09-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structures of Aedes aegypti Alanine Glyoxylate Aminotransferase.
J.Biol.Chem., 281, 2006
4ZYE
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BU of 4zye by Molmil
Crystal structure of Sulfolobus solfataricus O6-methylguanine methyltransferase
Descriptor: GLYCEROL, Methylated-DNA--protein-cysteine methyltransferase, NITRATE ION
Authors:Miggiano, R, Rossi, F, Rizzi, M.
Deposit date:2015-05-21
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein.
Nucleic Acids Res., 43, 2015
4ZYD
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BU of 4zyd by Molmil
Crystal structure of Sulfolobus solfataricus O6-methylguanine methyltransferase in complex with modified DNA
Descriptor: DNA (5'-D(*GP*CP*CP*AP*TP*GP*(6OG)P*CP*TP*AP*GP*TP*A)-3'), DNA (5'-D(*TP*AP*CP*TP*AP*GP*CP*CP*AP*TP*GP*GP*C)-3'), Methylated-DNA--protein-cysteine methyltransferase
Authors:Miggiano, R, Rossi, F, Rizzi, M.
Deposit date:2015-05-21
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.682 Å)
Cite:Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein.
Nucleic Acids Res., 43, 2015
2CH2
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Structure of the Anopheles gambiae 3-hydroxykynurenine transaminase in complex with inhibitor
Descriptor: 3-HYDROXYKYNURENINE TRANSAMINASE, 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID, PYRIDOXAL-5'-PHOSPHATE
Authors:Rossi, F, Garavaglia, S, Giovenzana, G.B, Arca, B, Li, J, Rizzi, M.
Deposit date:2006-03-10
Release date:2006-03-28
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of the Anopheles Gambiae 3-Hydroxykynurenine Transaminase
Proc.Natl.Acad.Sci.USA, 103, 2006
2CH1
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BU of 2ch1 by Molmil
Structure of Anopheles gambiae 3-hydroxykynurenine transaminase
Descriptor: 3-HYDROXYKYNURENINE TRANSAMINASE, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE
Authors:Rossi, F, Garavaglia, S, Giovenzana, G.B, Arca, B, Li, J, Rizzi, M.
Deposit date:2006-03-10
Release date:2006-03-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Anopheles Gambiae 3-Hydroxykynurenine Transaminase
Proc.Natl.Acad.Sci.USA, 103, 2006
4ZYG
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Crystal structure of methylated Sulfolobus solfataricus O6-methylguanine methyltransferase
Descriptor: Methylated-DNA--protein-cysteine methyltransferase
Authors:Miggiano, R, Rossi, F, Rizzi, M.
Deposit date:2015-05-21
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein.
Nucleic Acids Res., 43, 2015
4ZYH
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Crystal structure of Sulfolobus solfataricus O6-methylguanine methyltransferase C119L variant
Descriptor: Methylated-DNA--protein-cysteine methyltransferase
Authors:Miggiano, R, Rossi, F, Rizzi, M.
Deposit date:2015-05-21
Release date:2015-08-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein.
Nucleic Acids Res., 43, 2015
3ZTV
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BU of 3ztv by Molmil
Structure of Haemophilus influenzae NAD nucleotidase (NadN)
Descriptor: ADENOSINE, GLYCEROL, NAD NUCLEOTIDASE, ...
Authors:Garavaglia, S, Bruzzone, S, Cassani, C, Canella, L, Allegrone, G, Sturla, L, Mannino, E, Millo, E, De Flora, A, Rizzi, M.
Deposit date:2011-07-12
Release date:2011-12-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism.
Biochem.J., 441, 2012
1UMA
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BU of 1uma by Molmil
ALPHA-THROMBIN (HIRUGEN) COMPLEXED WITH NA-(N,N-DIMETHYLCARBAMOYL)-ALPHA-AZALYSINE
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-THROMBIN, HIRUDIN I, ...
Authors:Nardini, M, Pesce, A, Rizzi, M, Casale, E, Ferraccioli, R, Balliano, G, Milla, P, Ascenzi, P, Bolognesi, M.
Deposit date:1996-03-26
Release date:1996-11-08
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
J.Mol.Biol., 258, 1996
2XSR
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BU of 2xsr by Molmil
Crystal structure of wild type Acinetobacter radioresistens catechol 1,2 dioxygenase
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOINOSITOL, CATECHOL 1,2 DIOXYGENASE, FE (III) ION
Authors:Micalella, C, Martignon, S, Bruno, S, Rizzi, M.
Deposit date:2010-09-30
Release date:2010-12-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-Ray Crystallography, Mass Spectrometry and Single Crystal Microspectrophotometry: A Multidisciplinary Characterization of Catechol 1,2 Dioxygenase.
Biochim.Biophys.Acta, 1814, 2011
4YUB
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BU of 4yub by Molmil
Crystal structure of human Nicotinic Acid Phosphoribosyltransferase
Descriptor: Nicotinate phosphoribosyltransferase
Authors:Garavaglia, S, Rizzi, M, Marletta, A.S.
Deposit date:2015-03-18
Release date:2015-05-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of human nicotinic acid phosphoribosyltransferase.
Febs Open Bio, 5, 2015
3ZU0
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BU of 3zu0 by Molmil
Structure of Haemophilus influenzae NAD nucleotidase (NadN)
Descriptor: NAD NUCLEOTIDASE, PHOSPHATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Garavaglia, S, Bruzzone, S, Cassani, C, Canella, L, Allegrone, G, Sturla, L, Mannino, E, Millo, E, De Flora, A, Rizzi, M.
Deposit date:2011-07-13
Release date:2011-12-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism.
Biochem.J., 441, 2012

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