5HKL

Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with inorganic phosphate

Summary for 5HKL

Entry DOI	10.2210/pdb5hkl/pdb
Descriptor	Orotate phosphoribosyltransferase, PHOSPHATE ION (3 entities in total)
Functional Keywords	oprt, de novo pyrimidine nucleotide synthesis, inorganic phosphate complex, transferase
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	2
Total formula weight	40776.92
Authors	Donini, S.,Bolognesi, G.,Rizzi, M. (deposition date: 2016-01-14, release date: 2017-01-25, Last modification date: 2024-01-10)
Primary citation	Donini, S.,Ferraris, D.M.,Miggiano, R.,Massarotti, A.,Rizzi, M. Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis. Sci Rep, 7:1180-1180, 2017 Cited by PubMed: 28446777 DOI: 10.1038/s41598-017-01057-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.899 Å)

Structure validation