5HKF
Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with 5-phospho-alpha-D-ribosyl 1-diphosphate (PRPP)
Summary for 5HKF
| Entry DOI | 10.2210/pdb5hkf/pdb |
| Descriptor | Orotate phosphoribosyltransferase, 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose (3 entities in total) |
| Functional Keywords | transferase, oprt, de novo pyrimidine nucleotide synthesis, prpp complex |
| Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Total number of polymer chains | 2 |
| Total formula weight | 41185.80 |
| Authors | Donini, S.,Ferraris, D.M.,Bolognesi, G.,Rizzi, M. (deposition date: 2016-01-14, release date: 2017-01-25, Last modification date: 2024-01-10) |
| Primary citation | Donini, S.,Ferraris, D.M.,Miggiano, R.,Massarotti, A.,Rizzi, M. Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis. Sci Rep, 7:1180-1180, 2017 Cited by PubMed: 28446777DOI: 10.1038/s41598-017-01057-z PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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