5HKF

Crystal structure of Mycobacterium tuberculosis H37Rv orotate phosphoribosyltransferase in complex with 5-phospho-alpha-D-ribosyl 1-diphosphate (PRPP)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Orotate phosphoribosyltransferase	polymer	189	20202.8	2	UniProt (P9WHK9) Pfam (PF00156)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	OPRTase
2	C, D (A, B)	1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose	non-polymer		390.1	2	Chemie (PRP)
3	E, F (A, B)	water	water		18.0	87	Chemie (HOH)

Sequence modifications

A, B: 1 - 179 (UniProt: P9WHK9)

PDB	External Database	Details
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
Ile -4	-	expression tag
Glu -3	-	expression tag
Gly -2	-	expression tag
Arg -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	40405.7
Non-Polymers*	Number of molecules	2
	Total formula weight	780.1
All*	Total formula weight	41185.8

*Water molecules are not included.