1UMA

ALPHA-THROMBIN (HIRUGEN) COMPLEXED WITH NA-(N,N-DIMETHYLCARBAMOYL)-ALPHA-AZALYSINE

Summary for 1UMA

DescriptorALPHA-THROMBIN, HIRUDIN I, N-ACETYL-D-GLUCOSAMINE, ... (6 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, serine protease, kringle, alpha-thrombin- hirugen complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationSecreted, extracellular space P00734 P00734
Total number of polymer chains3
Total molecular weight35897.87
Authors
Nardini, M.,Pesce, A.,Rizzi, M.,Casale, E.,Ferraccioli, R.,Balliano, G.,Milla, P.,Ascenzi, P.,Bolognesi, M. (deposition date: 1996-03-26, release date: 1996-11-08, Last modification date: 2011-11-16)
Primary citation
Nardini, M.,Pesce, A.,Rizzi, M.,Casale, E.,Ferraccioli, R.,Balliano, G.,Milla, P.,Ascenzi, P.,Bolognesi, M.
Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
J.Mol.Biol., 258:851-859, 1996
PubMed: 8637015 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.1996.0292
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers180.7%11.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report