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PDB: 14 件

4GS7
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BU of 4gs7 by Molmil
Structure of the Interleukin-15 quaternary complex
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Ring, A.M, Ozkan, E, Feng, D, Garcia, K.C.
登録日2012-08-27
公開日2012-11-07
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
Nat.Immunol., 13, 2012
4KJY
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BU of 4kjy by Molmil
Complex of high-affinity SIRP alpha variant FD6 with CD47
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, High-affinity SIRPa variant FD6, Leukocyte surface antigen CD47, ...
著者Ring, A.M, Ozkan, E, Ho, C.C.M, Garcia, K.C.
登録日2013-05-04
公開日2013-06-12
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Engineered SIRP alpha variants as immunotherapeutic adjuvants to anticancer antibodies.
Science, 341, 2013
4LDL
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BU of 4ldl by Molmil
Structure of beta2 adrenoceptor bound to hydroxybenzylisoproterenol and an engineered nanobody
分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 4-[(1R)-1-hydroxy-2-{[1-(4-hydroxyphenyl)-2-methylpropan-2-yl]amino}ethyl]benzene-1,2-diol, Camelid Antibody Fragment, ...
著者Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K.
登録日2013-06-24
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
Nature, 502, 2013
4LDE
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Structure of beta2 adrenoceptor bound to BI167107 and an engineered nanobody
分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid Antibody Fragment, ...
著者Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K.
登録日2013-06-24
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
Nature, 502, 2013
4LDO
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Structure of beta2 adrenoceptor bound to adrenaline and an engineered nanobody
分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, Camelid Antibody Fragment, L-EPINEPHRINE, ...
著者Ring, A.M, Manglik, A, Kruse, A.C, Enos, M.D, Weis, W.I, Garcia, K.C, Kobilka, B.K.
登録日2013-06-24
公開日2013-09-25
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Adrenaline-activated structure of beta 2-adrenoceptor stabilized by an engineered nanobody.
Nature, 502, 2013
5IUS
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BU of 5ius by Molmil
Crystal structure of human PD-L1 in complex with high affinity PD-1 mutant
分子名称: CHLORIDE ION, Programmed cell death 1 ligand 1, Programmed cell death protein 1
著者Pascolutti, R, Sun, X, Kao, J, Maute, R, Ring, A.M, Bowman, G.R, Kruse, A.C.
登録日2016-03-18
公開日2016-09-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.889 Å)
主引用文献Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant.
Structure, 24, 2016
6BIT
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BU of 6bit by Molmil
SIRPalpha antibody complex
分子名称: KWAR23 Fab heavy chain, KWAR23 Fab light chain, Tyrosine-protein phosphatase non-receptor type substrate 1
著者Ring, N.G, Herndler-Brandstetter, D, Weiskopf, K, Shan, L, Volkmer, J.P, George, B.M, Lietzenmayer, M, McKenna, K.M, Naik, T.J, McCarty, A, Zheng, Y, Ring, A.M, Flavell, R.A, Weissman, I.L.
登録日2017-11-03
公開日2017-12-06
最終更新日2019-11-20
実験手法X-RAY DIFFRACTION (2.191 Å)
主引用文献Anti-SIRP alpha antibody immunotherapy enhances neutrophil and macrophage antitumor activity.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4MQS
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BU of 4mqs by Molmil
Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo
分子名称: 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Muscarinic acetylcholine receptor M2, Nanobody 9-8
著者Kruse, A.C, Ring, A.M, Manglik, A, Hu, J, Hu, K, Eitel, K, Huebner, H, Pardon, E, Valant, C, Sexton, P.M, Christopoulos, A, Felder, C.C, Gmeiner, P, Steyaert, J, Weis, W.I, Garcia, K.C, Wess, J, Kobilka, B.K.
登録日2013-09-16
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nature, 504, 2013
4MQT
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Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620
分子名称: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Muscarinic acetylcholine receptor M2, ...
著者Kruse, A.C, Ring, A.M, Manglik, A, Hu, J, Hu, K, Eitel, K, Huebner, H, Pardon, E, Valant, C, Sexton, P.M, Christopoulos, A, Felder, C.C, Gmeiner, P, Steyaert, J, Weis, W.I, Garcia, K.C, Wess, J, Kobilka, B.K.
登録日2013-09-16
公開日2013-11-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nature, 504, 2013
3QB1
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BU of 3qb1 by Molmil
Interleukin-2 mutant D10
分子名称: Interleukin-2
著者Levin, A.M, Bates, D.L, Ring, A.M, Lin, J.T, Su, L, Krieg, C, Bowman, G.R, Novick, P, Pande, V.S, Khort, H.E, Boyman, O, Fathman, C.G, Garcia, K.C.
登録日2011-01-12
公開日2012-04-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
Nature, 484, 2012
3QAZ
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BU of 3qaz by Molmil
IL-2 mutant D10 ternary complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-2, ...
著者Levin, A.M, Bates, D.L, Ring, A.M, Lin, J.T, Su, L, Krieg, C, Bowman, G.R, Novick, P, Pande, V.S, Khort, H.E, Boyman, O, Gathman, C.G, Garcia, K.C.
登録日2011-01-12
公開日2012-04-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.802 Å)
主引用文献Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
Nature, 484, 2012
2LAR
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BU of 2lar by Molmil
DNA / RNA Hybrid containing a central stereo specific Rp borano phosphate linkage
分子名称: DNA_(5'-D(*AP*TP*GP*GP*TP*BGR*CP*TP*C)-3')_, RNA_(5'-R(*GP*AP*GP*CP*AP*CP*CP*AP*U)-3')_
著者Johnson, C.N, Spring, A.M, Shaw, B.R, Germann, M.W.
登録日2011-03-18
公開日2011-10-12
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural basis of the RNase H1 activity on stereo regular borano phosphonate DNA/RNA hybrids.
Biochemistry, 50, 2011
2LIB
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BU of 2lib by Molmil
DNA sequence context conceals alpha anomeric lesion
分子名称: DNA (5'-D(*CP*GP*TP*CP*CP*TP*GP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*(A3A)P*GP*GP*AP*CP*G)-3')
著者Johnson, C.N, Spring, A.M, Cunningham, R.P, Germann, M.W.
登録日2011-08-27
公開日2012-08-08
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献DNA sequence context conceals alpha-anomeric lesions.
J.Mol.Biol., 416, 2012
2LB4
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BU of 2lb4 by Molmil
DNA / RNA Hybrid containing a central stereo specific Sp borano phosphate linkage
分子名称: DNA_(5'-D(*AP*TP*GP*GP*TP*BGR*CP*TP*C)-3')_, RNA_(5'-R(*GP*AP*GP*CP*AP*CP*CP*AP*U)-3')_
著者Johnson, C.N, Spring, A.M, Shaw, B.R, Germann, M.W.
登録日2011-03-22
公開日2011-06-29
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural Basis of the RNase H1 Activity on Stereo Regular Borano Phosphonate DNA/RNA Hybrids.
Biochemistry, 50, 2011

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件を2024-08-21に公開中

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