4KJY

Complex of high-affinity SIRP alpha variant FD6 with CD47

Summary for 4KJY

• Entry DOI: 10.2210/pdb4kjy/pdb
• Descriptor: Leukocyte surface antigen CD47, High-affinity SIRPa variant FD6, SULFATE ION, ... (5 entities in total)
• Functional Keywords: immunoglobulin fold, immune regulation, n-linked glycosylation, plasma membrane, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 59594.35

Authors

Ring, A.M.,Ozkan, E.,Ho, C.C.M.,Garcia, K.C. (deposition date: 2013-05-04, release date: 2013-06-12, Last modification date: 2020-07-29)

• Primary citation: Weiskopf, K.,Ring, A.M.,Ho, C.C.,Volkmer, J.P.,Levin, A.M.,Volkmer, A.K.,Ozkan, E.,Fernhoff, N.B.,van de Rijn, M.,Weissman, I.L.,Garcia, K.C.; Engineered SIRP alpha variants as immunotherapeutic adjuvants to anticancer antibodies.; Science, 341:88-91, 2013; PubMed: 23722425; DOI: 10.1126/science.1238856

Experimental method

X-RAY DIFFRACTION (1.93 Å)