4KJY
Complex of high-affinity SIRP alpha variant FD6 with CD47
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Leukocyte surface antigen CD47 | polymer | 125 | 14245.0 | 2 | UniProt (Q08722) Pfam (PF08204) In PDB | Homo sapiens (human) | Antigenic surface determinant protein OA3, Integrin-associated protein, IAP, Protein MER6 |
2 | B, D | High-affinity SIRPa variant FD6 | polymer | 133 | 14523.2 | 2 | Homo sapiens (human) | ||
3 | A, C, D | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
4 | A, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
5 | water | water | 18.0 | 378 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 117 (UniProt: Q08722)
PDB | External Database | Details |
---|---|---|
Gly 15 | Cys 33 | engineered mutation |
Thr 118 | - | expression tag |
Arg 119 | - | expression tag |
His 120 | - | expression tag |
His 121 | - | expression tag |
His 122 | - | expression tag |
His 123 | - | expression tag |
His 124 | - | expression tag |
His 125 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 57536.5 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 2057.9 | |
All* | Total formula weight | 59594.4 |