4KJY

Complex of high-affinity SIRP alpha variant FD6 with CD47

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Leukocyte surface antigen CD47	polymer	125	14245.0	2	UniProt (Q08722) Pfam (PF08204)	Homo sapiens (human)	Antigenic surface determinant protein OA3, Integrin-associated protein, IAP, Protein MER6
2	B, D (B, D)	High-affinity SIRPa variant FD6	polymer	133	14523.2	2		Homo sapiens (human)
3	E, N, O (A, C, D)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
4	F, G, H, I, J... (A, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
5	P, Q, R, S (A, B, C, D)	water	water		18.0	378	Chemie (HOH)

Sequence modifications

A, C: 1 - 117 (UniProt: Q08722)

PDB	External Database	Details
Gly 15	Cys 33	engineered mutation
Thr 118	-	expression tag
Arg 119	-	expression tag
His 120	-	expression tag
His 121	-	expression tag
His 122	-	expression tag
His 123	-	expression tag
His 124	-	expression tag
His 125	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	57536.5
Non-Polymers*	Number of molecules	11
	Total formula weight	2057.9
All*	Total formula weight	59594.4

*Water molecules are not included.