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PDB: 225 件

6ONS
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Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase with the D-cluster ligating cysteines mutated to alanines, coexpressed with CooC, as-isolated
分子名称: Carbon monoxide dehydrogenase, FE(4)-NI(1)-S(4) CLUSTER, IRON/SULFUR CLUSTER
著者Cohen, S.E, Wittenborn, E.C, Drennan, C.L.
登録日2019-04-22
公開日2019-07-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.485 Å)
主引用文献Structural insight into metallocofactor maturation in carbon monoxide dehydrogenase.
J.Biol.Chem., 294, 2019
6ONC
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Crystal structure of Desulfovibrio vulgaris carbon monoxide dehydrogenase produced without CooC, as-isolated
分子名称: CHLORIDE ION, Carbon monoxide dehydrogenase, FE (III) ION, ...
著者Wittenborn, E.C, Cohen, S.E, Drennan, C.L.
登録日2019-04-21
公開日2019-07-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural insight into metallocofactor maturation in carbon monoxide dehydrogenase.
J.Biol.Chem., 294, 2019
5L2R
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Crystal structure of fumarate hydratase from Leishmania major
分子名称: (2S)-2-hydroxybutanedioic acid, DI(HYDROXYETHYL)ETHER, Fumarate hydratase, ...
著者Feliciano, P.R, Drennan, C.L, Nonato, M.C.
登録日2016-08-02
公開日2016-08-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.054 Å)
主引用文献Crystal structure of an Fe-S cluster-containing fumarate hydratase enzyme from Leishmania major reveals a unique protein fold.
Proc.Natl.Acad.Sci.USA, 113, 2016
4XC6
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Isobutyryl-CoA mutase fused with bound adenosylcobalamin, GDP, and Mg (holo-IcmF/GDP)
分子名称: 5'-DEOXYADENOSINE, ACETATE ION, COBALAMIN, ...
著者Jost, M, Drennan, C.L.
登録日2014-12-17
公開日2015-02-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Visualization of a radical B12 enzyme with its G-protein chaperone.
Proc.Natl.Acad.Sci.USA, 112, 2015
6ND3
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wild-type choline TMA lyase in complex with betaine aldehyde
分子名称: BETAINE ALDEHYDE, Choline trimethylamine-lyase
著者Funk, M.A, Drennan, C.L.
登録日2018-12-13
公開日2019-01-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.364 Å)
主引用文献Structure-Guided Identification of a Small Molecule That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria.
J.Am.Chem.Soc., 141, 2019
6UNZ
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BU of 6unz by Molmil
Crystal structure of cytosolic fumarate hydratase from Leishmania major
分子名称: GLYCEROL, IRON/SULFUR CLUSTER, fumarate hydratase 2
著者Feliciano, P.R, Drennan, C.L.
登録日2019-10-14
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.195 Å)
主引用文献Structural and Biochemical Investigations of the [4Fe-4S] Cluster-Containing Fumarate Hydratase fromLeishmania major.
Biochemistry, 58, 2019
6MSO
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BU of 6mso by Molmil
Crystal structure of mitochondrial fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate
分子名称: (2S)-2-sulfanylbutanedioic acid, GLYCEROL, IRON/SULFUR CLUSTER, ...
著者Feliciano, P.R, Drennan, C.L, Nonato, M.C.
登録日2018-10-17
公開日2019-01-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.053 Å)
主引用文献Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate.
ACS Chem. Biol., 14, 2019
2R0C
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Structure of the substrate-free form of the rebeccamycin biosynthetic enzyme REBC
分子名称: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, RebC
著者Ryan, K.S, Drennan, C.L.
登録日2007-08-18
公開日2007-09-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC
Proc.Natl.Acad.Sci.Usa, 104, 2007
2R0P
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K252c-soaked RebC
分子名称: 6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Ryan, K.S, Drennan, C.L.
登録日2007-08-20
公開日2007-09-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC
Proc.Natl.Acad.Sci.Usa, 104, 2007
6UOJ
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BU of 6uoj by Molmil
Crystal structure of cytosolic fumarate hydratase from Leishmania major in a complex with succinate
分子名称: Fumarate hydratase 2, GLYCEROL, IRON/SULFUR CLUSTER, ...
著者Feliciano, P.R, Drennan, C.L.
登録日2019-10-15
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural and Biochemical Investigations of the [4Fe-4S] Cluster-Containing Fumarate Hydratase fromLeishmania major.
Biochemistry, 58, 2019
6XOJ
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ScoE with the CABA substrate bound and alpha-ketoglutarate in an off-site
分子名称: (3~{R})-3-(2-hydroxy-2-oxoethylamino)butanoic acid, 2-OXOGLUTARIC ACID, ACETATE ION, ...
著者Jonnalagadda, R, Drennan, C.L.
登録日2020-07-07
公開日2021-01-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Biochemical and crystallographic investigations into isonitrile formation by a nonheme iron-dependent oxidase/decarboxylase.
J.Biol.Chem., 296, 2021
6VWZ
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BU of 6vwz by Molmil
Crystal structure of air-exposed C45G/T50C D. vulgaris carbon monoxide dehydrogenase (20 minute air exposure)
分子名称: Carbon monoxide dehydrogenase, Fe(4)-Ni(1)-S(4) cluster, oxidized, ...
著者Wittenborn, E.C, Drennan, C.L.
登録日2020-02-20
公開日2020-07-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.488 Å)
主引用文献The Solvent-Exposed Fe-S D-Cluster Contributes to Oxygen-Resistance inDesulfovibrio vulgarisNi-Fe Carbon Monoxide Dehydrogenase.
Acs Catalysis, 10, 2020
6VX0
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BU of 6vx0 by Molmil
Crystal structure of air-exposed C45G/T50C D. vulgaris carbon monoxide dehydrogenase (2 hour air exposure)
分子名称: Carbon monoxide dehydrogenase, Fe(4)-Ni(1)-S(4) cluster, oxidized, ...
著者Wittenborn, E.C, Drennan, C.L.
登録日2020-02-20
公開日2020-07-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献The Solvent-Exposed Fe-S D-Cluster Contributes to Oxygen-Resistance inDesulfovibrio vulgarisNi-Fe Carbon Monoxide Dehydrogenase.
Acs Catalysis, 10, 2020
6VX1
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BU of 6vx1 by Molmil
Crystal structure of air-exposed C45G/T50C D. vulgaris carbon monoxide dehydrogenase (2 day air exposure)
分子名称: Carbon monoxide dehydrogenase, Fe(4)-Ni(1)-S(4) cluster, oxidized, ...
著者Wittenborn, E.C, Drennan, C.L.
登録日2020-02-20
公開日2020-07-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献The Solvent-Exposed Fe-S D-Cluster Contributes to Oxygen-Resistance inDesulfovibrio vulgarisNi-Fe Carbon Monoxide Dehydrogenase.
Acs Catalysis, 10, 2020
6NX0
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BU of 6nx0 by Molmil
Crystal structure of the diheme peroxidase BthA from Burkholderia thailandensis E264
分子名称: CHLORIDE ION, Di-haem cytochrome c peroxidase family protein, GLYCEROL, ...
著者Cohen, S.E, Drennan, C.L.
登録日2019-02-07
公開日2019-03-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献A widely distributed diheme enzyme from Burkholderia that displays an atypically stable bis-Fe(IV) state.
Nat Commun, 10, 2019
6XO3
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BU of 6xo3 by Molmil
ScoE with alpha-ketoglutarate in an off-site
分子名称: 2-OXOGLUTARIC ACID, CHLORIDE ION, FE (II) ION, ...
著者Jonnalagadda, R, Drennan, C.L.
登録日2020-07-06
公開日2021-01-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Biochemical and crystallographic investigations into isonitrile formation by a nonheme iron-dependent oxidase/decarboxylase.
J.Biol.Chem., 296, 2021
6XN6
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BU of 6xn6 by Molmil
ScoE with the CABA substrate bound and His299 and Arg157 flipped out
分子名称: (3~{R})-3-(2-hydroxy-2-oxoethylamino)butanoic acid, ACETATE ION, CHLORIDE ION, ...
著者Jonnalagadda, R, Drennan, C.L.
登録日2020-07-02
公開日2021-01-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Biochemical and crystallographic investigations into isonitrile formation by a nonheme iron-dependent oxidase/decarboxylase.
J.Biol.Chem., 296, 2021
6N2N
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BU of 6n2n by Molmil
Crystal structure of 2-oxoglutarate:ferredoxin oxidoreductase from Magnetococcus marinus
分子名称: IRON/SULFUR CLUSTER, MAGNESIUM ION, Pyruvate ferredoxin/flavodoxin oxidoreductase, ...
著者Chen, P.Y.-T, Drennan, C.L.
登録日2018-11-13
公開日2019-03-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.937 Å)
主引用文献A reverse TCA cycle 2-oxoacid:ferredoxin oxidoreductase that makes C-C bonds from CO2.
Joule, 3, 2019
8USQ
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BU of 8usq by Molmil
Structural and biochemical investigations of a HEAT-repeat protein involved in the cytosolic iron-sulfur cluster assembly pathway
分子名称: DNA repair/transcription protein MET18/MMS19
著者Vasquez, S, Drennan, C.L.
登録日2023-10-29
公開日2023-12-27
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (12.77 Å)
主引用文献Structural and biochemical investigations of a HEAT-repeat protein involved in the cytosolic iron-sulfur cluster assembly pathway.
Commun Biol, 6, 2023
6N2O
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2-oxoglutarate:ferredoxin oxidoreductase from Magnetococcus marinus with 2-oxoglutarate, coenzyme A and succinyl-CoA bound
分子名称: 2-OXOGLUTARIC ACID, COENZYME A, IRON/SULFUR CLUSTER, ...
著者Chen, P.Y.-T, Drennan, C.L.
登録日2018-11-13
公開日2019-03-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.824 Å)
主引用文献A reverse TCA cycle 2-oxoacid:ferredoxin oxidoreductase that makes C-C bonds from CO2.
Joule, 3, 2019
8V9I
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1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Deinococcus radiodurans with D-phenylalanine-derived triazole acetylphosphonate (D-PheTrAP) bound
分子名称: 1-deoxy-D-xylulose-5-phosphate synthase, 2-HYDROXY BUTANE-1,4-DIOL, 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1S)-1-[(S)-(2-{1-[(1R)-1-carboxy-2-phenylethyl]-1H-1,2,3-triazol-4-yl}ethoxy)(hydroxy)phosphoryl]-1-hydroxyethyl}-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, ...
著者Chen, P.Y.-T, Drennan, C.L.
登録日2023-12-08
公開日2024-04-24
実験手法X-RAY DIFFRACTION (1.981 Å)
主引用文献Potent Inhibition of E. coli DXP Synthase by a gem -Diaryl Bisubstrate Analog.
Acs Infect Dis., 10, 2024
6OUV
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1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Deinococcus radiodurans with methylacetylphosphonate (MAP) bound
分子名称: 1-deoxy-D-xylulose-5-phosphate synthase, 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-{(1S)-1-HYDROXY-1-[(R)-HYDROXY(METHOXY)PHOSPHORYL]ETHYL}-5-(2-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM, MAGNESIUM ION, ...
著者Chen, P.Y.-T, Drennan, C.L.
登録日2019-05-05
公開日2019-07-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.937 Å)
主引用文献X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.
J.Biol.Chem., 294, 2019
6OUW
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1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Deinococcus radiodurans with enamine intermediate bound
分子名称: 1-deoxy-D-xylulose-5-phosphate synthase, 2-ACETYL-THIAMINE DIPHOSPHATE, MAGNESIUM ION, ...
著者Chen, P.Y.-T, Drennan, C.L.
登録日2019-05-05
公開日2019-07-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.398 Å)
主引用文献X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.
J.Biol.Chem., 294, 2019
6UQN
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Crystal structure of R173A variant of cytosolic fumarate hydratase from Leishmania major in a complex with fumarate and S-malate
分子名称: (2S)-2-hydroxybutanedioic acid, FUMARIC ACID, Fumarate hydratase 2, ...
著者Feliciano, P.R, Drennan, C.L.
登録日2019-10-21
公開日2019-12-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (3.298 Å)
主引用文献Structural and Biochemical Investigations of the [4Fe-4S] Cluster-Containing Fumarate Hydratase fromLeishmania major.
Biochemistry, 58, 2019
6OWR
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NMR solution structure of YfiD
分子名称: Autonomous glycyl radical cofactor
著者Bowman, S.E.J, Drennan, C.L.
登録日2019-05-10
公開日2019-07-10
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Solution structure and biochemical characterization of a spare part protein that restores activity to an oxygen-damaged glycyl radical enzyme.
J.Biol.Inorg.Chem., 24, 2019

224004

件を2024-08-21に公開中

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