6UOJ

Crystal structure of cytosolic fumarate hydratase from Leishmania major in a complex with succinate

Summary for 6UOJ

Related6UNZ 6UO0 6UOI
DescriptorFumarate hydratase 2, IRON/SULFUR CLUSTER, SUCCINIC ACID, ... (5 entities in total)
Functional Keywordsfumarate hydratase, fumarase, leishmania major, inhibitor, succinate, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological sourceLeishmania major strain Friedlin
Total number of polymer chains2
Total molecular weight134150.58
Authors
Feliciano, P.R.,Drennan, C.L. (deposition date: 2019-10-15, release date: 2019-12-04, Last modification date: 2019-12-18)
Primary citation
Feliciano, P.R.,Drennan, C.L.
Structural and Biochemical Investigations of the [4Fe-4S] Cluster-Containing Fumarate Hydratase fromLeishmania major.
Biochemistry, 58:5011-5021, 2019
PubMed: 31743022 (PDB entries with the same primary citation)
DOI: 10.1021/acs.biochem.9b00923
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.35 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20230 2.5% 0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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