6OUV

1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Deinococcus radiodurans with methylacetylphosphonate (MAP) bound

Summary for 6OUV

• Entry DOI: 10.2210/pdb6ouv/pdb
• Related: 6OUW
• Descriptor: 1-deoxy-D-xylulose-5-phosphate synthase, 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-{(1S)-1-HYDROXY-1-[(R)-HYDROXY(METHOXY)PHOSPHORYL]ETHYL}-5-(2-{[(S)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: 1-deoxy-d-xylulose 5-phosphate synthase, dxps, thiamine diphosphate, thiamine pyrophosphate, thdp, tpp, changes, the mep pathway, transferase
• Biological source: Deinococcus radiodurans
• Total number of polymer chains: 2
• Total formula weight: 141280.35

Authors

Chen, P.Y.-T.,Drennan, C.L. (deposition date: 2019-05-05, release date: 2019-07-03, Last modification date: 2023-10-11)

• Primary citation: Chen, P.Y.,DeColli, A.A.,Freel Meyers, C.L.,Drennan, C.L.; X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.; J.Biol.Chem., 294:12405-12414, 2019; PubMed: 31239351; DOI: 10.1074/jbc.RA119.009321

Experimental method

X-RAY DIFFRACTION (1.937 Å)