8V9I
1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Deinococcus radiodurans with D-phenylalanine-derived triazole acetylphosphonate (D-PheTrAP) bound
This is a non-PDB format compatible entry.
Summary for 8V9I
Entry DOI | 10.2210/pdb8v9i/pdb |
Descriptor | 1-deoxy-D-xylulose-5-phosphate synthase, 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1S)-1-[(S)-(2-{1-[(1R)-1-carboxy-2-phenylethyl]-1H-1,2,3-triazol-4-yl}ethoxy)(hydroxy)phosphoryl]-1-hydroxyethyl}-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | 1-deoxy-d-xylulose 5-phosphate synthase, dxps, thiamine diphosphate, thiamine pyrophosphate, thdp, tpp, the mep pathway, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Deinococcus radiodurans |
Total number of polymer chains | 2 |
Total formula weight | 141843.93 |
Authors | |
Primary citation | Coco, L.B.,Toci, E.M.,Chen, P.Y.,Drennan, C.L.,Freel Meyers, C.L. Potent Inhibition of E. coli DXP Synthase by a gem -Diaryl Bisubstrate Analog. Acs Infect Dis., 10:1312-1326, 2024 Cited by PubMed: 38513073DOI: 10.1021/acsinfecdis.3c00734 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.981 Å) |
Structure validation
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