6OUW

1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Deinococcus radiodurans with enamine intermediate bound

Summary for 6OUW

• Entry DOI: 10.2210/pdb6ouw/pdb
• Related: 6OUV
• Descriptor: 1-deoxy-D-xylulose-5-phosphate synthase, 2-ACETYL-THIAMINE DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: 1-deoxy-d-xylulose 5-phosphate synthase, dxps, thiamine diphosphate, thiamine pyrophosphate, thdp, tpp, changes, the mep pathway, transferase
• Biological source: Deinococcus radiodurans
• Total number of polymer chains: 1
• Total formula weight: 70544.15

Authors

Chen, P.Y.-T.,Drennan, C.L. (deposition date: 2019-05-05, release date: 2019-07-03, Last modification date: 2023-10-11)

• Primary citation: Chen, P.Y.,DeColli, A.A.,Freel Meyers, C.L.,Drennan, C.L.; X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.; J.Biol.Chem., 294:12405-12414, 2019; PubMed: 31239351; DOI: 10.1074/jbc.RA119.009321

Experimental method

X-RAY DIFFRACTION (2.398 Å)