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PDB: 722 results

8IW8
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crystal structure of SulE mutant
Descriptor: Alpha/beta fold hydrolase, GLYCEROL, L(+)-TARTARIC ACID
Authors:Liu, B, He, J, Ran, T, Wang, W.
Deposit date:2023-03-29
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:crystal structure of SulE mutant
To Be Published
6OUC
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Asymmetric focsued reconstruction of human norovirus GII.2 Snow Mountain Virus strain VLP asymmetric unit in T=1 symmetry
Descriptor: Viral protein 1, ZINC ION
Authors:Jung, J, Grant, T, Thomas, D.R, Diehnelt, C.W, Grigorieff, N, Joshua-Tor, L.
Deposit date:2019-05-04
Release date:2019-06-26
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OUU
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BU of 6ouu by Molmil
Symmetric reconstruction of human norovirus GII.4 Minerva strain VLP in T=4 symmetry
Descriptor: Major capsid protein
Authors:Jung, J, Grant, T, Thomas, D.R, Diehnelt, C.W, Grigorieff, N, Joshua-Tor, L.
Deposit date:2019-05-05
Release date:2019-06-26
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations.
Proc.Natl.Acad.Sci.USA, 116, 2019
4UWF
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BU of 4uwf by Molmil
Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors
Descriptor: (8S)-9-[3,5-bis(fluoranyl)phenyl]-2-morpholin-4-yl-8-(trifluoromethyl)-7,8-dihydro-6H-pyrimido[1,2-a]pyrimidin-4-one, PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3
Authors:Pasquier, B, El-Ahmad, Y, Filoche-Romme, B, Dureuil, C, Fassy, F, Abecassis, P.Y, Mathieu, M, Bertrand, T, Benard, T, Barriere, C, ElBatti, S, Letallec, J.P, Sonnefraud, V, Brollo, M, Delbarre, L, Loyau, V, Pilorge, F, Bertin, L, Richepin, P, Arigon, J, Labrosse, J.R, Clement, J, Durand, F, Combet, R, Perraut, P, Leroy, V, Gay, F, Lefrancois, D, Bretin, F, Marquette, J.P, Michot, N, Caron, A, Castell, C, Schio, L, McCort, G, Goulaouic, H, Garcia-Echeverria, C, Ronan, B.
Deposit date:2014-08-12
Release date:2014-11-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxobutyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors.
J.Med.Chem., 58, 2015
1VT7
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BU of 1vt7 by Molmil
Structures of the mismatched duplex D(GGGTGCCC)
Descriptor: DNA (5'-D(*GP*GP*GP*TP*GP*CP*CP*C)-3')
Authors:Rabinovich, D, Haran, T, Eisenstein, M, Shakked, Z.
Deposit date:1996-12-02
Release date:2011-07-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the mismatched duplex d(GGGTGCCC) and one of its Watson-Crick analogues d(GGGCGCCC).
J.Mol.Biol., 200, 1988
2PR0
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BU of 2pr0 by Molmil
Crystal structure of Sylvaticin, a new secreted protein from Pythium Sylvaticum
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, NICKEL (II) ION, sylvaticin
Authors:Lascombe, M.B, Prange, T, Retailleau, P.
Deposit date:2007-05-03
Release date:2008-03-18
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structure of sylvaticin, a new alpha-elicitin-like protein from Pythium sylvaticum.
Acta Crystallogr.,Sect.D, 63, 2007
1HY7
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A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3
Descriptor: CALCIUM ION, R-2-{[4'-METHOXY-(1,1'-BIPHENYL)-4-YL]-SULFONYL}-AMINO-6-METHOXY-HEX-4-YNOIC ACID, STROMELYSIN-1, ...
Authors:Natchus, M.G, Bookland, R.G, Laufersweiler, M.J, Pikul, S, Almstead, N.G, De, B, Janusz, M.J, Hsieh, L.C, Gu, F, Pokross, M.E, Patel, V.S, Garver, S.M, Peng, S.X, Branch, T.M, King, S.L, Baker, T.R, Foltz, D.J, Mieling, G.E.
Deposit date:2001-01-18
Release date:2002-01-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.
J.Med.Chem., 44, 2001
2QJ6
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BU of 2qj6 by Molmil
Crystal structure analysis of a 14 repeat C-terminal fragment of toxin TcdA in Clostridium difficile
Descriptor: Toxin A
Authors:Albesa-Jove, D, Bertrand, T, Carpenter, L, Lim, J, Brown, K.A, Fairweather, N.
Deposit date:2007-07-06
Release date:2008-07-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Solution and crystal structures of the cell binding domain of toxins TcdA and TcdB from Clostridium difficile
To be Published
1ICG
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BU of 1icg by Molmil
STRUCTURE OF THE HYBRID RNA/DNA R-GCUUCGGC-D[F]U IN PRESENCE OF IR(NH3)6+++
Descriptor: 5'-R(*GP*CP*UP*UP*CP*GP*GP*C)-D(P*(UFP))-3', CHLORIDE ION, IRIDIUM HEXAMMINE ION
Authors:Cruse, W, Saludjian, P, Neuman, A, Prange, T.
Deposit date:2001-03-31
Release date:2001-04-09
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Destabilizing effect of a fluorouracil extra base in a hybrid RNA duplex compared with bromo and chloro analogues.
Acta Crystallogr.,Sect.D, 57, 2001
1ID9
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BU of 1id9 by Molmil
STRUCTURE OF THE HYBRID RNA/DNA R-GCUUCGGC-D[F]U IN PRESENCE OF RH(NH3)6+++
Descriptor: 5'-R(*GP*CP*UP*UP*CP*GP*GP*C)-D(P*(UFP))-3', CHLORIDE ION, RHODIUM HEXAMINE ION
Authors:Cruse, W, Saludjian, P, Neuman, A, Prange, T.
Deposit date:2001-04-04
Release date:2001-04-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Destabilizing effect of a fluorouracil extra base in a hybrid RNA duplex compared with bromo and chloro analogues.
Acta Crystallogr.,Sect.D, 57, 2001
3BXX
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BU of 3bxx by Molmil
Binding of two substrate analogue molecules to dihydroflavonol 4-reductase alters the functional geometry of the catalytic site
Descriptor: 3,5,7,3',4'-PENTAHYDROXYFLAVONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, dihydroflavonol 4-reductase
Authors:Trabelsi, N, Petit, P, Granier, T, Langlois d'Estaintot, B, Delrot, S, Gallois, B.
Deposit date:2008-01-15
Release date:2008-10-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural evidence for the inhibition of grape dihydroflavonol 4-reductase by flavonols
Acta Crystallogr.,Sect.D, D64, 2008
3BK8
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BU of 3bk8 by Molmil
Urate oxidase aza-xanthine complex in cyanide
Descriptor: 8-AZAXANTHINE, SODIUM ION, Uricase
Authors:Gabison, L, Prange, T, Colloc'h, N, El Hajji, M, Castro, B, Chiadmi, M.
Deposit date:2007-12-06
Release date:2008-08-12
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural analysis of urate oxidase in complex with its natural substrate inhibited by cyanide: Mechanistic implications
Bmc Struct.Biol., 8, 2008
8A97
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BU of 8a97 by Molmil
ROOM TEMPERATURE CRYSTAL STRUCTURE OF THE COFACTOR-DEVOID 1-H-3-HYDROXY-4- OXOQUINALDINE 2,4-DIOXYGENASE (HOD) UNDER XENON PRESSURE (30 bar)
Descriptor: 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase, D(-)-TARTARIC ACID, XENON
Authors:Bui, S, Prange, T, Steiner, R.A.
Deposit date:2022-06-27
Release date:2023-07-05
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.897 Å)
Cite:Evolutionary adaptation from hydrolytic to oxygenolytic catalysis at the alpha / beta-hydrolase fold.
Chem Sci, 14, 2023
5XEZ
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BU of 5xez by Molmil
Structure of the Full-length glucagon class B G protein-coupled receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide, ...
Authors:Zhang, H, Qiao, A, Yang, D, Yang, L, Dai, A, de Graaf, C, Reedtz-Runge, S, Dharmarajan, V, Zhang, H, Han, G.W, Grant, T, Sierra, R, Weierstall, U, Nelson, G, Liu, W, Wu, Y, Ma, L, Cai, X, Lin, G, Wu, X, Geng, Z, Dong, Y, Song, G, Griffin, P, Lau, J, Cherezov, V, Yang, H, Hanson, M, Stevens, R, Jiang, H, Wang, M, Zhao, Q, Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
2FEM
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BU of 2fem by Molmil
Mutant R188M of the Cytidine Monophosphate Kinase From E. Coli
Descriptor: Cytidylate kinase
Authors:Ofiteru, A, Bucurenci, N, Alexov, E, Bertrand, T, Briozzo, P, Munier-Lehmann, H, Tourneux, L, Barzu, O, Gilles, A.M.
Deposit date:2005-12-16
Release date:2006-01-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase.
Febs J., 274, 2007
3T6F
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BU of 3t6f by Molmil
Biotin complex of Y54F core streptavidin
Descriptor: BIOTIN, BIOTIN-D-SULFOXIDE, GLYCEROL, ...
Authors:Baugh, L, Le Trong, I, Cerutti, D.S, Mehta, N, Gulich, S, Stayton, P.S, Stenkamp, R.E, Lybrand, T.P.
Deposit date:2011-07-28
Release date:2011-12-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Second-Contact Shell Mutation Diminishes Streptavidin-Biotin Binding Affinity through Transmitted Effects on Equilibrium Dynamics.
Biochemistry, 51, 2012
3T6L
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BU of 3t6l by Molmil
Y54F mutant of core streptavidin
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Streptavidin
Authors:Baugh, L, Le Trong, I, Stayton, P.S, Stenkamp, R.E, Lybrand, T.P.
Deposit date:2011-07-28
Release date:2011-12-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Second-Contact Shell Mutation Diminishes Streptavidin-Biotin Binding Affinity through Transmitted Effects on Equilibrium Dynamics.
Biochemistry, 51, 2012
3K7R
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BU of 3k7r by Molmil
Crystal structure of [TM][CuAtx1]3
Descriptor: COPPER (II) ION, D-MALATE, Metal homeostasis factor ATX1, ...
Authors:Xue, Y, Alvarez, H.M, Robinson, C.D, Mondragon, A, O'Halloran, T.V.
Deposit date:2009-10-13
Release date:2009-11-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Tetrathiomolybdate inhibits copper trafficking proteins through metal cluster formation.
Science, 327, 2010
4YH8
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BU of 4yh8 by Molmil
Structure of yeast U2AF complex
Descriptor: Splicing factor U2AF 23 kDa subunit, Splicing factor U2AF 59 kDa subunit, ZINC ION
Authors:Yoshida, H, Park, S.Y, Urano, T, Obayashi, E.
Deposit date:2015-02-27
Release date:2015-08-12
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A novel 3' splice site recognition by the two zinc fingers in the U2AF small subunit.
Genes Dev., 29, 2015
5ZJK
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BU of 5zjk by Molmil
Structure of myroilysin
Descriptor: Myroilysin, PHOSPHATE ION, ZINC ION
Authors:Li, W.D, Ran, T.T, Xu, D.Q, Wang, W.W.
Deposit date:2018-03-20
Release date:2019-03-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of mature myroilysin and implication for its activation mechanism.
Int.J.Biol.Macromol., 2019
5Y0E
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BU of 5y0e by Molmil
Crystal structure of TssK
Descriptor: SULFATE ION, TssK
Authors:Tong, H, Xu, D, Ran, T, Wang, W.W.
Deposit date:2017-07-17
Release date:2018-08-08
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of TssK at 2.5 Angstroms resolution.
To Be Published
5Y57
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BU of 5y57 by Molmil
Crystal structure of a Novel Pyrethroid Hydrolase from Sphingobium faniae JZ-2
Descriptor: Pyrethroid hydrolase, SULFATE ION, phenylmethanesulfonic acid
Authors:Xu, D.Q, Ran, T.T, He, J, Wang, W.W.
Deposit date:2017-08-07
Release date:2018-08-08
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.961 Å)
Cite:Structure and Catalytic Mechanism of a Novel Pyrethroid Hydrolase from Sphingobium faniae JZ-2
To Be Published
5Y5V
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BU of 5y5v by Molmil
Crystal structure of a novel Pyrethroid Hydrolase PytH (S78A)
Descriptor: Pyrethroid hydrolase, SULFATE ION
Authors:Xu, D.Q, Ran, T.T, He, J, Wang, W.W.
Deposit date:2017-08-09
Release date:2018-08-15
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structure and Catalytic Mechanism of a Novel Pyrethroid Hydrolase from Sphingobium faniae JZ-2
To Be Published
5Y5R
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Crystal structure of a novel Pyrethroid Hydrolase PytH with BIF
Descriptor: (2-methyl-3-phenyl-phenyl)methyl (1~{S})-3-[(~{E})-2-chloranyl-3,3,3-tris(fluoranyl)prop-1-enyl]-2,2-dimethyl-cyclopropane-1-carboxylate, Pyrethroid hydrolase, SULFATE ION
Authors:Xu, D.Q, Ran, T.T, Wang, W.W.
Deposit date:2017-08-09
Release date:2018-08-15
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Structure and Catalytic Mechanism of a Novel Pyrethroid Hydrolase from Sphingobium faniae JZ-2
To Be Published
4MTY
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BU of 4mty by Molmil
Structure at 1A resolution of a helical aromatic foldamer-protein complex.
Descriptor: 4-(HYDROXYMERCURY)BENZOIC ACID, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Ogayone, T, Buratto, J, Langlois D'Estaintot, B, Stupfel, M, Granier, T, Gallois, B, Huc, Y.
Deposit date:2013-09-20
Release date:2013-12-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1 Å)
Cite:Structure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 a resolution.
Angew.Chem.Int.Ed.Engl., 53, 2014

227561

數據於2024-11-20公開中

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