3KXV

Structure of complement Factor H variant Q1139A

Summary for 3KXV

• Entry DOI: 10.2210/pdb3kxv/pdb
• Related: 2G7I 3KZJ
• Descriptor: Complement factor H, SULFATE ION (3 entities in total)
• Functional Keywords: sushi domain, short consensus repeat domain, scr domain, complement control protein module, complement regulator, atypical hemolytic uremic syndrome, renal disease, cfh, complement alternative pathway, disease mutation, glycoprotein, immune response, innate immunity, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P08603
• Total number of polymer chains: 1
• Total formula weight: 15618.51

Authors

Bhattacharjee, A.,Lehtinen, M.J.,Kajander, T.,Goldman, A.,Jokiranta, T.S. (deposition date: 2009-12-04, release date: 2010-05-19, Last modification date: 2023-11-01)

• Primary citation: Bhattacharjee, A.,Lehtinen, M.J.,Kajander, T.,Goldman, A.,Jokiranta, T.S.; Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d; Mol.Immunol., 47:1686-1691, 2010; PubMed: 20378178; DOI: 10.1016/j.molimm.2010.03.007

Experimental method

X-RAY DIFFRACTION (2.004 Å)