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PDB: 22 results

8DEA
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Scaffold Hopping via Ring Opening Enables Identification of Acyclic Compounds as New Complement Factor D Inhibitors
Descriptor: 1-[(3-acetylphenyl)acetyl]-N-(6-bromopyridin-2-yl)-L-prolinamide, Complement factor D, GLYCEROL
Authors:Raman, K, Babu, Y.S.
Deposit date:2022-06-20
Release date:2022-11-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.214 Å)
Cite:Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors.
Bioorg.Med.Chem., 74, 2022
8DG6
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Scaffold Hopping via Ring Opening Enables Identification of Acyclic Compounds as New Complement Factor D Inhibitors
Descriptor: 1-{2-[(2S)-2-{[(3-chloro-2-fluorophenyl)methyl]carbamoyl}pyrrolidin-1-yl]-2-oxoethyl}-1H-indazole-3-carboxamide, Complement factor D
Authors:Raman, K, Babu, Y.S.
Deposit date:2022-06-23
Release date:2022-11-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.986 Å)
Cite:Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors.
Bioorg.Med.Chem., 74, 2022
8D95
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Scaffold Hopping via Ring Opening Enables Identification of Acyclic Compounds as New Complement Factor D Inhibitors
Descriptor: Complement factor D, N-(6-bromopyridin-2-yl)-1-[(3-cyanophenyl)acetyl]-L-prolinamide
Authors:Raman, K, Babu, Y.S.
Deposit date:2022-06-09
Release date:2022-11-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.166 Å)
Cite:Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors.
Bioorg.Med.Chem., 74, 2022
2EC9
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Crystal structure analysis of human Factor VIIa , Souluble tissue factor complexed with BCX-3607
Descriptor: 1,5-anhydro-D-glucitol, 2'-((5-CARBAMIMIDOYLPYRIDIN-2-YLAMINO)METHYL)-4-(ISOBUTYLCARBAMOYL)-4'-VINYLBIPHENYL-2-CARBOXYLIC ACID, CALCIUM ION, ...
Authors:Raman, K, Yarlagadda, B.
Deposit date:2007-02-13
Release date:2008-02-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Probing the S2 site of factor VIIa to generate potent and selective inhibitors: the structure of BCX-3607 in complex with tissue factor-factor VIIa.
Acta Crystallogr.,Sect.D, 63, 2007
4ACP
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BU of 4acp by Molmil
Deactivation of human IgG1 Fc by endoglycosidase treatment
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, IG GAMMA-1 CHAIN C REGION
Authors:Raman, K, Bowden, T.A, Krishna, B.A, Dwek, R.A, Crispin, M, Scanlan, C.N.
Deposit date:2011-12-16
Release date:2012-04-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Selective Deactivation of Serum Igg: A General Strategy for the Enhancement of Monoclonal Antibody Receptor Interactions.
J.Mol.Biol., 420, 2012
8ONT
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Structure of Setaria italica NRAT in complex with a nanobody
Descriptor: DIUNDECYL PHOSPHATIDYL CHOLINE, NRAMP related aluminium transporter, Nanobody1
Authors:Ramanadane, K, Liziczai, M, Markovic, D, Straub, M.S, Rosalen, G.T, Udovcic, A, Dutzler, R, Manatschal, C.
Deposit date:2023-04-03
Release date:2023-04-12
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Structural and functional properties of a plant NRAMP-related aluminum transporter.
Elife, 12, 2023
8DNN
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Crystal structure of neutralizing antibody 80 in complex with SARS-CoV-2 receptor binding domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 80 FAB HEAVY CHAIN, 80 FAB LIGHT CHAIN, ...
Authors:Muthuraman, K, Kucharska, I, Ivanochko, D, Julien, J.P.
Deposit date:2022-07-11
Release date:2023-05-24
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:A multi-specific, multi-affinity antibody platform neutralizes sarbecoviruses and confers protection against SARS-CoV-2 in vivo.
Sci Transl Med, 15, 2023
7QIA
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Structure of apo-EleNRMT in complex with two nanobodies at 3.5A
Descriptor: Divalent metal cation transporter, Nanobody 1, Nanobody 2
Authors:Ramanadane, K, Straub, M.S, Dutzler, R, Manatschal, C.
Deposit date:2021-12-14
Release date:2021-12-29
Last modified:2022-02-02
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family.
Elife, 11, 2022
7QIC
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Structure of magnesium-bound EleNRMT in complex with two nanobodies at 4.1A
Descriptor: Divalent metal cation transporter, MAGNESIUM ION, Nanobody 1, ...
Authors:Ramanadane, K, Straub, M.S, Dutzler, R, Manatschal, C.
Deposit date:2021-12-14
Release date:2021-12-29
Last modified:2022-02-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family.
Elife, 11, 2022
7QJI
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X-Ray Structure of apo-EleNRMT in complex with two Nanobodies at 4.1A
Descriptor: Divalent metal cation transporter, Elen-Nanobody-complex
Authors:Ramanadane, K, Straub, M.S, Dutzler, R, Manatschal, C.
Deposit date:2021-12-16
Release date:2022-02-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family.
Elife, 11, 2022
7QJJ
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X-Ray Structure of a Mn2+ soak of EleNRMT in complex with two Nanobodies at 4.6A
Descriptor: Divalent metal cation transporter, Elen-Nb1-Nb2, MANGANESE (II) ION
Authors:Ramanadane, K, Straub, M.S, Dutzler, R, Manatschal, C.
Deposit date:2021-12-16
Release date:2022-02-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (4.6 Å)
Cite:Structural and functional properties of a magnesium transporter of the SLC11/NRAMP family.
Elife, 11, 2022
1RKU
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BU of 1rku by Molmil
Crystal Structure of ThrH gene product of Pseudomonas Aeruginosa
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, homoserine kinase
Authors:Singh, S.K, Yang, K, Subramanian, K, Karthikeyan, S, Huynh, T, Zhang, X, Phillips, M.A, Zhang, H.
Deposit date:2003-11-23
Release date:2004-03-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:The thrH Gene Product of Pseudomonas aeruginosa Is a Dual Activity Enzyme with a Novel Phosphoserine:Homoserine Phosphotransferase Activity.
J.Biol.Chem., 279, 2004
1RKV
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BU of 1rkv by Molmil
Structure of Phosphate complex of ThrH from Pseudomonas aeruginosa
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Singh, S.K, Yang, K, Subramanian, K, Karthikeyan, S, Huynh, T, Zhang, X, Phillips, M.A, Zhang, H.
Deposit date:2003-11-23
Release date:2004-03-30
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The thrH Gene Product of Pseudomonas aeruginosa Is a Dual Activity Enzyme with a Novel Phosphoserine:Homoserine Phosphotransferase Activity.
J.Biol.Chem., 279, 2004
7K0Z
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BU of 7k0z by Molmil
Marsupial T cell receptor Spl_157
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, T cell receptor gamma chain, T cell receptor mu chain
Authors:Wegrecki, M, Kannan Sivaraman, K, Le Nours, J, Rossjohn, J.
Deposit date:2020-09-06
Release date:2021-03-24
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The molecular assembly of the marsupial gamma mu T cell receptor defines a third T cell lineage.
Science, 371, 2021
7K0X
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Marsupial T cell receptor Spl_145
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, T cell receptor gamma chain, T cell receptor mu chain, ...
Authors:Wegrecki, M, Kannan Sivaraman, K, Le Nours, J, Rossjohn, J.
Deposit date:2020-09-06
Release date:2021-03-24
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The molecular assembly of the marsupial gamma mu T cell receptor defines a third T cell lineage.
Science, 371, 2021
7L15
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BU of 7l15 by Molmil
Marsupial T cell receptor Spl_118
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, T cell receptor gamma chain, ...
Authors:Wegrecki, M, Kannan Sivaraman, K, Praveena, T, Le Nours, J, Rossjohn, J.
Deposit date:2020-12-14
Release date:2021-03-24
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The molecular assembly of the marsupial gamma mu T cell receptor defines a third T cell lineage.
Science, 371, 2021
8Y4Z
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Monomeric HERC5 HECT c-lobe structure in solution
Descriptor: E3 ISG15--protein ligase HERC5
Authors:Dag, C, Lambert, M, Kahraman, K, Lohn, F, Lee, W, Gocenler, O, Guntert, P, Dotsch, V.
Deposit date:2024-01-31
Release date:2024-02-14
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Monomeric HERC5 HECT c-lobe structure in solution
To Be Published
1ZW8
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BU of 1zw8 by Molmil
Solution structure of a ZAP1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae
Descriptor: ZINC ION, Zinc-responsive transcriptional regulator ZAP1
Authors:Wang, Z, Feng, L.S, Venkataraman, K, Matskevich, V.A, Parasuram, P, Laity, J.H.
Deposit date:2005-06-03
Release date:2006-01-10
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of a Zap1 zinc-responsive domain provides insights into metalloregulatory transcriptional repression in Saccharomyces cerevisiae.
J.Mol.Biol., 357, 2006
4GC5
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BU of 4gc5 by Molmil
Crystal structure of murine TFB1M
Descriptor: ACETATE ION, Dimethyladenosine transferase 1, mitochondrial
Authors:Guja, K.E, Yakubovskaya, E, Shi, H, Mejia, E, Hambardjieva, E, Venkataraman, K, Karzai, A.W, Garcia-Diaz, M.
Deposit date:2012-07-29
Release date:2013-07-10
Last modified:2013-10-02
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Structural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1.
Nucleic Acids Res., 41, 2013
4GC9
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Crystal structure of murine TFB1M in complex with SAM
Descriptor: ACETATE ION, Dimethyladenosine transferase 1, mitochondrial, ...
Authors:Guja, K.E, Yakubovskaya, E, Shi, H, Mejia, E, Hambardjieva, E, Venkataraman, K, Karzai, A.W, Garcia-Diaz, M.
Deposit date:2012-07-30
Release date:2013-07-10
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:Structural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1.
Nucleic Acids Res., 41, 2013
2F2K
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Aldose reductase tertiary complex with NADPH and DEG
Descriptor: Aldose reductase, GAMMA-GLUTAMYL-S-(1,2-DICARBOXYETHYL)CYSTEINYLGLYCINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Singh, R, White, M.A, Ramana, K.V, Petrash, J.M, Watowich, S.J, Bhatnagar, A, Srivastava, S.K.
Deposit date:2005-11-17
Release date:2006-05-16
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structure of a glutathione conjugate bound to the active site of aldose reductase.
Proteins, 64, 2006
2I6Y
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Structure and Mechanism of Mycobacterium tuberculosis Salicylate Synthase, MbtI
Descriptor: Anthranilate synthase component I, putative
Authors:Zwahlen, J, Subramaniapillai, K, Zhou, R, Kisker, C, Tonge, P.J.
Deposit date:2006-08-29
Release date:2007-06-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and mechanism of MbtI, the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 46, 2007

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