2F2K

Aldose reductase tertiary complex with NADPH and DEG

Summary for 2F2K

• Entry DOI: 10.2210/pdb2f2k/pdb
• Related: 1ADS
• Descriptor: Aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GAMMA-GLUTAMYL-S-(1,2-DICARBOXYETHYL)CYSTEINYLGLYCINE, ... (4 entities in total)
• Functional Keywords: inhibitor, glutathione, tertiary complex, dicarboxyethyl glutathione, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 1
• Total formula weight: 37067.16

Authors

Singh, R.,White, M.A.,Ramana, K.V.,Petrash, J.M.,Watowich, S.J.,Bhatnagar, A.,Srivastava, S.K. (deposition date: 2005-11-17, release date: 2006-05-16, Last modification date: 2023-08-23)

• Primary citation: Singh, R.,White, M.A.,Ramana, K.V.,Petrash, J.M.,Watowich, S.J.,Bhatnagar, A.,Srivastava, S.K.; Structure of a glutathione conjugate bound to the active site of aldose reductase.; Proteins, 64:101-110, 2006; PubMed: 16639747; DOI: 10.1002/prot.20988

Experimental method

X-RAY DIFFRACTION (1.94 Å)