6L1O
 
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6PMA
 | | TRK-A IN COMPLEX WITH LIGAND | | 分子名称: | High affinity nerve growth factor receptor, N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[1-(4-methoxyphenyl)-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl]acetamide | | 著者 | Subramanian, G, Brown, D.G. | | 登録日 | 2019-07-01 | | 公開日 | 2020-02-26 | | 最終更新日 | 2021-02-03 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | Synthetic inhibitor leads of human tropomyosin receptor kinase A ( h TrkA).
Rsc Med Chem, 11, 2020
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6PL1
 | | TRK-A IN COMPLEX WITH LIGAND 1B | | 分子名称: | High affinity nerve growth factor receptor, N-(5-{[(7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)-N'-[3-(trifluoromethyl)phenyl]urea | | 著者 | Subramanian, G. | | 登録日 | 2019-06-30 | | 公開日 | 2019-10-09 | | 最終更新日 | 2019-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Lead identification and characterization of hTrkA type 2 inhibitors.
Bioorg.Med.Chem.Lett., 29, 2019
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6PMB
 | | TRK-A IN COMPLEX WITH LIGAND 1a | | 分子名称: | 2-[5,7-dimethyl-2-(pyridin-3-yl)[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]-N-[3-(trifluoromethyl)phenyl]acetamide, High affinity nerve growth factor receptor | | 著者 | Subramanian, G, Brown, D.G. | | 登録日 | 2019-07-01 | | 公開日 | 2020-02-26 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Synthetic inhibitor leads of human tropomyosin receptor kinase A ( h TrkA).
Rsc Med Chem, 11, 2020
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6PL2
 | | TRK-A IN COMPLEX WITH LIGAND 1a | | 分子名称: | High affinity nerve growth factor receptor, N-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)-2-{[1-(4-hydroxyphenyl)-1H-tetrazol-5-yl]sulfanyl}acetamide | | 著者 | Subramanian, G. | | 登録日 | 2019-06-30 | | 公開日 | 2019-09-04 | | 最終更新日 | 2019-09-25 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Type 2 inhibitor leads of human tropomyosin receptor kinase (hTrkA).
Bioorg.Med.Chem.Lett., 29, 2019
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6PL4
 | | TRK-A IN COMPLEX WITH LIGAND 1 | | 分子名称: | High affinity nerve growth factor receptor, N-{[5-(methoxymethyl)-2-(trifluoromethoxy)phenyl]methyl}-N'-(8-methyl-2-phenylimidazo[1,2-a]pyrazin-3-yl)urea | | 著者 | Subramanian, G, Brown, D.G. | | 登録日 | 2019-06-30 | | 公開日 | 2020-07-01 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | In Pursuit of an Allosteric Human Tropomyosin Kinase A (hTrkA) Inhibitor for Chronic Pain
Acs Med.Chem.Lett., 2021
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6PME
 | | TRK-A IN COMPLEX WITH LIGAND | | 分子名称: | High affinity nerve growth factor receptor, N-[2,4-bis(morpholin-4-yl)phenyl]-3-phenoxybenzamide, S,R MESO-TARTARIC ACID, ... | | 著者 | Subramanian, G, Brown, D.G. | | 登録日 | 2019-07-01 | | 公開日 | 2020-02-26 | | 最終更新日 | 2021-02-03 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Synthetic inhibitor leads of human tropomyosin receptor kinase A ( h TrkA).
Rsc Med Chem, 11, 2020
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6PL3
 | | TRK-A IN COMPLEX WITH LIGAND 2a | | 分子名称: | 2-[(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)amino]-2-oxoethyl 4-(1H-tetrazol-1-yl)benzoate, High affinity nerve growth factor receptor | | 著者 | Subramanian, G. | | 登録日 | 2019-06-30 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Type 2 inhibitor leads of human tropomyosin receptor kinase (hTrkA).
Bioorg.Med.Chem.Lett., 29, 2019
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6PMC
 | | TRK-A IN COMPLEX WITH LIGAND 1a | | 分子名称: | High affinity nerve growth factor receptor, N-(6-{[(5-chloro-2-methoxyphenyl)carbamoyl]amino}-1,3-benzothiazol-2-yl)benzamide | | 著者 | Subramanian, G, Brown, D.G. | | 登録日 | 2019-07-01 | | 公開日 | 2020-02-26 | | 最終更新日 | 2021-02-03 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Synthetic inhibitor leads of human tropomyosin receptor kinase A ( h TrkA).
Rsc Med Chem, 11, 2020
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1JO1
 | | N7-Guanine Adduct of 2,7-diaminomitosene with DNA | | 分子名称: | 5'-D(*GP*TP*GP*(DAJ)GP*TP*AP*TP*AP*CP*CP*AP*C)-3', DECARBAMOYL-2,7-DIAMINOMITOSENE | | 著者 | Subramaniam, G, Paz, M.M, Kumar, G.S, Das, A, Palom, Y, Clement, C.C, Patel, D.J, Tomasz, M. | | 登録日 | 2001-07-26 | | 公開日 | 2001-09-12 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity.
Biochemistry, 40, 2001
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6NSP
 | | TRK-A IN COMPLEX WITH LIGAND 9 | | 分子名称: | High affinity nerve growth factor receptor, N-(8-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)-2-(3-oxo-2,3-dihydro-4H-1,4-benzothiazin-4-yl)acetamide | | 著者 | Subramanian, G, Brown, D.G. | | 登録日 | 2019-01-25 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A ( hTrkA) Inhibitors.
Acs Chem.Biol., 14, 2019
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6NSS
 | | TRK-A IN COMPLEX WITH LIGAND 6 | | 分子名称: | High affinity nerve growth factor receptor, N-(8-methyl-2-phenylimidazo[1,2-a]pyrazin-3-yl)-2-(10H-phenoxazin-10-yl)acetamide | | 著者 | Subramanian, G, Brown, D.G. | | 登録日 | 2019-01-25 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A ( hTrkA) Inhibitors.
Acs Chem.Biol., 14, 2019
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6NPT
 | | TRK-A IN COMPLEX WITH LIGAND 1 | | 分子名称: | 4-tert-butyl-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide, High affinity nerve growth factor receptor | | 著者 | Subramanian, G. | | 登録日 | 2019-01-18 | | 公開日 | 2019-05-22 | | 最終更新日 | 2019-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A ( hTrkA) Inhibitors.
Acs Chem.Biol., 14, 2019
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1CHV
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6L1L
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6L1N
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1F9B
 | | MELANIN PROTEIN INTERACTION: X-RAY STRUCTURE OF THE COMPLEX OF MARE LACTOFERRIN WITH MELANIN MONOMERS | | 分子名称: | 3H-INDOLE-5,6-DIOL, BICARBONATE ION, FE (III) ION, ... | | 著者 | Kumar, S, Singh, T.P, Sharma, A.K, Singh, N, Raman, G. | | 登録日 | 2000-07-10 | | 公開日 | 2001-02-10 | | 最終更新日 | 2018-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Lactoferrin-melanin interaction and its possible implications in melanin polymerization: crystal structure of the complex formed between mare lactoferrin and melanin monomers at 2.7-A resolution.
Proteins, 45, 2001
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1OYO
 | | Regulation of protease activity by melanin: Crystal structure of the complex formed between proteinase K and melanin monomers at 2.0 resolution | | 分子名称: | 3H-INDOLE-5,6-DIOL, CALCIUM ION, Proteinase K | | 著者 | Singh, N, Sharma, S, Kumar, S, Raman, G, Singh, T.P. | | 登録日 | 2003-04-06 | | 公開日 | 2003-05-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Regulation of protease activity by melanin: Crystal structure of the complex formed between proteinase K and melanin monomers at 2.0 resolution
To be Published
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6LVB
 | | Structure of Dimethylformamidase, tetramer | | 分子名称: | FE (III) ION, N,N-dimethylformamidase large subunit, N,N-dimethylformamidase small subunit | | 著者 | Arya, C.A, Yadav, S, Fine, J, Casanal, A, Chopra, G, Ramanathan, G, Subramanian, R, Vinothkumar, K.R. | | 登録日 | 2020-02-02 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | A 2-Tyr-1-carboxylate Mononuclear Iron Center Forms the Active Site of a Paracoccus Dimethylformamidase.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6LVE
 | | Structure of Dimethylformamidase, tetramer, E521A mutant | | 分子名称: | N,N-dimethylformamidase large subunit, N,N-dimethylformamidase small subunit | | 著者 | Arya, C.A, Yadav, S, Fine, J, Casanal, A, Chopra, G, Ramanathan, G, Subramanian, R, Vinothkumar, K.R. | | 登録日 | 2020-02-02 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | A 2-Tyr-1-carboxylate Mononuclear Iron Center Forms the Active Site of a Paracoccus Dimethylformamidase.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6LVC
 | | Structure of Dimethylformamidase, dimer | | 分子名称: | FE (III) ION, N,N-dimethylformamidase large subunit, N,N-dimethylformamidase small subunit | | 著者 | Arya, C.A, Yadav, S, Fine, J, Casanal, A, Chopra, G, Ramanathan, G, Subramanian, R, Vinothkumar, K.R. | | 登録日 | 2020-02-02 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | A 2-Tyr-1-carboxylate Mononuclear Iron Center Forms the Active Site of a Paracoccus Dimethylformamidase.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6LVD
 | | Structure of Dimethylformamidase, tetramer, Y440A mutant | | 分子名称: | N,N-dimethylformamidase large subunit, N,N-dimethylformamidase small subunit | | 著者 | Arya, C.A, Yadav, S, Fine, J, Casanal, A, Chopra, G, Ramanathan, G, Subramanian, R, Vinothkumar, K.R. | | 登録日 | 2020-02-02 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | A 2-Tyr-1-carboxylate Mononuclear Iron Center Forms the Active Site of a Paracoccus Dimethylformamidase.
Angew.Chem.Int.Ed.Engl., 59, 2020
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5ZSX
 | | Catechol 2,3-dioxygenase with 3-fluorocatechol from Diaphorobacter sp DS2 | | 分子名称: | 1,2-ETHANEDIOL, 3-FLUOROBENZENE-1,2-DIOL, CALCIUM ION, ... | | 著者 | Mishra, K, Arya, C.K, Subramanian, R, Ramanathan, G. | | 登録日 | 2018-04-30 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Catechol 2,3-dioxygenase with 3-fluorocatechol from Diaphorobacter sp DS2.
To Be Published
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5ZNH
 | | Catechol 2,3-dioxygenase with 4-methyl catechol from Diaphorobacter sp DS2 | | 分子名称: | 1,2-ETHANEDIOL, 4-METHYLCATECHOL, CALCIUM ION, ... | | 著者 | Mishra, K, Arya, C.K, Subramaniyan, R, Ramanathan, G. | | 登録日 | 2018-04-09 | | 公開日 | 2019-04-17 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | catechol 2,3-dioxygenase with 4-methyl catechol from Diaphorobacter sp DS2
To Be Published
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5ZSZ
 | | Catechol 2,3-dioxygenase (C23O64) from Diaphorobacter sp DS2 | | 分子名称: | CALCIUM ION, Catechol 2,3-dioxygenase, Extradiol ring cleavage protein, ... | | 著者 | Mishra, K, Arya, C.K, Subramanian, R, Ramanathan, G. | | 登録日 | 2018-04-30 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Catechol 2,3-dioxygenase (C23O64) from Diaphorobacter sp DS2
To Be Published
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