6PL1

TRK-A IN COMPLEX WITH LIGAND 1B

Summary for 6PL1

Entry DOI	10.2210/pdb6pl1/pdb
Descriptor	High affinity nerve growth factor receptor, N-(5-{[(7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)-N'-[3-(trifluoromethyl)phenyl]urea (3 entities in total)
Functional Keywords	trk-a kinase domain high affinity nerve growth factor receptor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35921.22
Authors	Subramanian, G. (deposition date: 2019-06-30, release date: 2019-10-09, Last modification date: 2019-10-30)
Primary citation	Subramanian, G.,Zhu, Y.,Bowen, S.J.,Roush, N.,White, J.A.,Huczek, D.,Zachary, T.,Javens, C.,Williams, T.,Janssen, A.,Gonzales, A. Lead identification and characterization of hTrkA type 2 inhibitors. Bioorg.Med.Chem.Lett., 29:126680-126680, 2019 Cited by PubMed: 31610943 DOI: 10.1016/j.bmcl.2019.126680 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation