6NPT
TRK-A IN COMPLEX WITH LIGAND 1
Summary for 6NPT
Entry DOI | 10.2210/pdb6npt/pdb |
Descriptor | High affinity nerve growth factor receptor, 4-tert-butyl-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (3 entities in total) |
Functional Keywords | trk-a kinase domain high affinity nerve growth factor receptor inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35217.52 |
Authors | Subramanian, G. (deposition date: 2019-01-18, release date: 2019-05-22, Last modification date: 2019-07-10) |
Primary citation | Subramanian, G.,Johnson, P.D.,Zachary, T.,Roush, N.,Zhu, Y.,Bowen, S.J.,Janssen, A.,Duclos, B.A.,Williams, T.,Javens, C.,Shalaly, N.D.,Molina, D.M.,Wittwer, A.J.,Hirsch, J.L. Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A ( hTrkA) Inhibitors. Acs Chem.Biol., 14:1205-1216, 2019 Cited by PubMed: 31059222DOI: 10.1021/acschembio.9b00126 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
Download full validation report