6PMB

TRK-A IN COMPLEX WITH LIGAND 1a

Summary for 6PMB

• Entry DOI: 10.2210/pdb6pmb/pdb
• Related: 6PMA
• Descriptor: High affinity nerve growth factor receptor, 2-[5,7-dimethyl-2-(pyridin-3-yl)[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]-N-[3-(trifluoromethyl)phenyl]acetamide (3 entities in total)
• Functional Keywords: trk-a kinase domain, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 35775.14

Authors

Subramanian, G.,Brown, D.G. (deposition date: 2019-07-01, release date: 2020-02-26, Last modification date: 2024-03-13)

• Primary citation: Subramanian, G.,Vairagoundar, R.,Bowen, S.J.,Roush, N.,Zachary, T.,Javens, C.,Williams, T.,Janssen, A.,Gonzales, A.; Synthetic inhibitor leads of human tropomyosin receptor kinase A ( h TrkA).; Rsc Med Chem, 11:370-377, 2020; PubMed: 33479642; DOI: 10.1039/c9md00554d

Experimental method

X-RAY DIFFRACTION (2.81 Å)