6PMA
TRK-A IN COMPLEX WITH LIGAND
Summary for 6PMA
Entry DOI | 10.2210/pdb6pma/pdb |
Descriptor | High affinity nerve growth factor receptor, N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[1-(4-methoxyphenyl)-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl]acetamide (3 entities in total) |
Functional Keywords | trk-a kinase domain, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35906.55 |
Authors | Subramanian, G.,Brown, D.G. (deposition date: 2019-07-01, release date: 2020-02-26, Last modification date: 2021-02-03) |
Primary citation | Subramanian, G.,Vairagoundar, R.,Bowen, S.J.,Roush, N.,Zachary, T.,Javens, C.,Williams, T.,Janssen, A.,Gonzales, A. Synthetic inhibitor leads of human tropomyosin receptor kinase A ( h TrkA). Rsc Med Chem, 11:370-377, 2020 Cited by PubMed: 33479642DOI: 10.1039/c9md00554d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.53 Å) |
Structure validation
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