6NSP
TRK-A IN COMPLEX WITH LIGAND 9
Summary for 6NSP
Entry DOI | 10.2210/pdb6nsp/pdb |
Related | 6NPT |
Descriptor | High affinity nerve growth factor receptor, N-(8-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)-2-(3-oxo-2,3-dihydro-4H-1,4-benzothiazin-4-yl)acetamide (3 entities in total) |
Functional Keywords | trk-a kinase domain high affinity nerve growth factor receptor inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 34133.48 |
Authors | Subramanian, G.,Brown, D.G. (deposition date: 2019-01-25, release date: 2019-05-22, Last modification date: 2024-03-13) |
Primary citation | Subramanian, G.,Johnson, P.D.,Zachary, T.,Roush, N.,Zhu, Y.,Bowen, S.J.,Janssen, A.,Duclos, B.A.,Williams, T.,Javens, C.,Shalaly, N.D.,Molina, D.M.,Wittwer, A.J.,Hirsch, J.L. Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A ( hTrkA) Inhibitors. Acs Chem.Biol., 14:1205-1216, 2019 Cited by PubMed: 31059222DOI: 10.1021/acschembio.9b00126 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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