4MPC
| Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS2 | 分子名称: | 4-(isoindolin-2-ylsulfonyl)benzene-1,3-diol, L(+)-TARTARIC ACID, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, ... | 著者 | Gui, W.J, Tso, S.C, Chuang, J.L, Wu, C.Y, Qi, X, Tambar, U.K, Wynn, R.M, Chuang, D.T. | 登録日 | 2013-09-12 | 公開日 | 2014-01-01 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | 主引用文献 | Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket. J.Biol.Chem., 289, 2014
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4NJI
| Crystal Structure of QueE from Burkholderia multivorans in complex with AdoMet, 6-carboxy-5,6,7,8-tetrahydropterin, and Mg2+ | 分子名称: | (6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridine-6-carboxylic acid, 7-carboxy-7-deazaguanine synthase, IRON/SULFUR CLUSTER, ... | 著者 | Dowling, D.P, Bruender, N.A, Young, A.P, McCarty, R.M, Bandarian, V, Drennan, C.L. | 登録日 | 2013-11-10 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.197 Å) | 主引用文献 | Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism. Nat.Chem.Biol., 10, 2014
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4NEC
| Conversion of a Disulfide Bond into a Thioacetal Group during Echinomycin Biosynthesis | 分子名称: | 2-CARBOXYQUINOXALINE, ACETATE ION, Echinomycin, ... | 著者 | Hotta, K, Keegan, R.M, Ranganathan, S, Fang, M, Bibby, J, Winn, M.D, Sato, M, Lian, M, Watanabe, K, Rigden, D.J, Kim, C.-Y. | 登録日 | 2013-10-29 | 公開日 | 2014-01-15 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Conversion of a disulfide bond into a thioacetal group during echinomycin biosynthesis. Angew.Chem.Int.Ed.Engl., 53, 2014
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4NJH
| Crystal Structure of QueE from Burkholderia multivorans in complex with AdoMet and 6-carboxy-5,6,7,8-tetrahydropterin | 分子名称: | (6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridine-6-carboxylic acid, 7-carboxy-7-deazaguanine synthase, IRON/SULFUR CLUSTER, ... | 著者 | Dowling, D.P, Bruender, N.A, Young, A.P, McCarty, R.M, Bandarian, V, Drennan, C.L. | 登録日 | 2013-11-10 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | 主引用文献 | Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism. Nat.Chem.Biol., 10, 2014
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4NH0
| Cytoplasmic domain of the Thermomonospora curvata Type VII Secretion ATPase EccC | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell divisionFtsK/SpoIIIE, MAGNESIUM ION, ... | 著者 | Rosenberg, O.S, Cox, J.S, Stroud, R.M, Strauli, N, Dovala, D. | 登録日 | 2013-11-03 | 公開日 | 2015-02-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell(Cambridge,Mass.), 161, 2015
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4NJJ
| Crystal Structure of QueE from Burkholderia multivorans in complex with AdoMet, 6-carboxy-5,6,7,8-tetrahydropterin, and Manganese(II) | 分子名称: | (6R)-2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridine-6-carboxylic acid, 7-carboxy-7-deazaguanine synthase, IRON/SULFUR CLUSTER, ... | 著者 | Dowling, D.P, Bruender, N.A, Young, A.P, McCarty, R.M, Bandarian, V, Drennan, C.L. | 登録日 | 2013-11-10 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism. Nat.Chem.Biol., 10, 2014
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4P2E
| Acoustic transfer of protein crystals from agar pedestals to micromeshes for high throughput screening of heavy atom derivatives | 分子名称: | CHLORIDE ION, COPPER (II) ION, Lysozyme C, ... | 著者 | Cuttitta, C.M, Roessler, C.G, Ericson, D.L, Scalia, A, Teplitsky, E, Campos, O, Agarwal, R, Allaire, M, Orville, A.M, Sweet, R.M, Soares, A.S. | 登録日 | 2014-03-03 | 公開日 | 2014-04-09 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Acoustic transfer of protein crystals from agarose pedestals to micromeshes for high-throughput screening. Acta Crystallogr.,Sect.D, 71, 2015
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4M8B
| Fungal Protein | 分子名称: | 1,2-ETHANEDIOL, Chain A of dsDNA containing the cis-regulatory element, Chain B of dsDNA containing the cis-regulatory element, ... | 著者 | Rosenberg, O.S, Lohse, M.L, Stroud, R.M, Johnson, A.D. | 登録日 | 2013-08-13 | 公開日 | 2014-06-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi. Proc.Natl.Acad.Sci.USA, 111, 2014
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4PIW
| Crystal structure of sugar aminotransferase WecE from Escherichia coli K-12 | 分子名称: | TDP-4-keto-6-deoxy-D-glucose transaminase family protein | 著者 | Wang, F, Xu, W, Helmich, K.E, Singh, S, Yennamalli, R.M, Miller, M.D, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2014-05-09 | 公開日 | 2014-07-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of sugar aminotransferase WecE from Escherichia coli K-12 To Be Published
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2G0B
| The structure of FeeM, an N-acyl amino acid synthase from uncultured soil microbes | 分子名称: | FeeM, N-DODECANOYL-L-TYROSINE | 著者 | Van Wagoner, R.M, Clardy, J. | 登録日 | 2006-02-11 | 公開日 | 2006-09-26 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | FeeM, an N-Acyl Amino Acid Synthase from an Uncultured Soil Microbe: Structure, Mechanism, and Acyl Carrier Protein Binding. Structure, 14, 2006
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6M9U
| Structure of the apo-form of 20beta-Hydroxysteroid Dehydrogenase from Bifidobacterium adolescentis strain L2-32 | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | 著者 | Mythen, S.M, Pollet, R.M, Koropatkin, N.M, Ridlon, J.M. | 登録日 | 2018-08-24 | 公開日 | 2019-06-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and biochemical characterization of 20 beta-hydroxysteroid dehydrogenase fromBifidobacterium adolescentisstrain L2-32. J.Biol.Chem., 294, 2019
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2G8A
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2GFD
| GRP94 in complex with the novel HSP90 Inhibitor Radamide | 分子名称: | Endoplasmin, METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE, PENTAETHYLENE GLYCOL, ... | 著者 | Immormino, R.M, Gewirth, D.T. | 登録日 | 2006-03-21 | 公開日 | 2007-04-03 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design. J.Mol.Biol., 388, 2009
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7V6P
| Crystal structure of human sNASP TPR domain | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Liu, C.P, Xu, R.M. | 登録日 | 2021-08-20 | 公開日 | 2021-12-29 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. Genes Dev., 35, 2021
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7V6Q
| Crystal structure of sNASP-ASF1A-H3.1-H4 complex | 分子名称: | GLYCEROL, Histone H3.1, Histone H4, ... | 著者 | Liu, C.P, Xu, R.M. | 登録日 | 2021-08-20 | 公開日 | 2021-12-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. Genes Dev., 35, 2021
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2FX7
| Crystal structure of hiv-1 neutralizing human fab 4e10 in complex with a 16-residue peptide encompassing the 4e10 epitope on gp41 | 分子名称: | Fab 4E10, Fragment of HIV glycoprotein (GP41), GLYCEROL | 著者 | Cardoso, R.M.F, Brunel, F.M, Ferguson, S, Burton, D.R, Dawson, P.E, Wilson, I.A. | 登録日 | 2006-02-03 | 公開日 | 2006-12-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10. J.Mol.Biol., 365, 2007
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7V9G
| Native BEN4 domain of protein Bend3 with DNA | 分子名称: | BEN domain-containing protein 3, DNA (5'-D(*GP*CP*AP*CP*CP*GP*CP*GP*TP*GP*GP*GP*GP*CP*CP*A)-3'), DNA (5'-D(*TP*GP*GP*CP*CP*CP*CP*AP*CP*GP*CP*GP*GP*TP*GP*C)-3') | 著者 | Zhang, J, Zhang, Y, You, Q, Huang, C, Zhang, T, Wang, M, Zhang, T, Yang, X, Xiong, J, Li, Y, Liu, C.P, Zhang, Z, Xu, R.M, Zhu, B. | 登録日 | 2021-08-25 | 公開日 | 2022-02-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science, 375, 2022
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7V9I
| The Monomer mutant of BEN4 domain of protein Bend3 with DNA | 分子名称: | BEN domain-containing protein 3, DNA (5'-D(*AP*CP*CP*GP*CP*GP*TP*GP*GP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*CP*CP*AP*CP*GP*CP*GP*GP*T)-3') | 著者 | Zhang, J, Zhang, Y, You, Q, Huang, C, Zhang, T, Wang, M, Zhang, T, Yang, X, Xiong, J, Li, Y, Liu, C.P, Zhang, Z, Xu, R.M, Zhu, B. | 登録日 | 2021-08-25 | 公開日 | 2022-02-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science, 375, 2022
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2GF7
| Double tudor domain structure | 分子名称: | Jumonji domain-containing protein 2A, SULFATE ION | 著者 | Huang, Y, Fang, J, Bedford, M.T, Zhang, Y, Xu, R.M. | 登録日 | 2006-03-21 | 公開日 | 2006-05-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A Science, 312, 2006
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7V9H
| The BEN3 domain of protein Bend3 | 分子名称: | BEN domain-containing protein 3 | 著者 | Zhang, J, Zhang, Y, You, Q, Huang, C, Zhang, T, Wang, M, Zhang, T, Yang, X, Xiong, J, Li, Y, Liu, C.P, Zhang, Z, Xu, R.M, Zhu, B. | 登録日 | 2021-08-25 | 公開日 | 2022-02-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.692 Å) | 主引用文献 | Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science, 375, 2022
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7V9F
| Selenomethionine mutant (L740Sem) of BEN4 domain of protein Bend3 with DNA | 分子名称: | BEN domain-containing protein 3, CITRIC ACID, DNA (5'-D(*GP*CP*AP*CP*CP*GP*CP*GP*TP*GP*GP*GP*GP*CP*CP*A)-3'), ... | 著者 | Zhang, J, Zhang, Y, You, Q, Huang, C, Zhang, T, Wang, M, Zhang, T, Yang, X, Xiong, J, Li, Y, Liu, C.P, Zhang, Z, Xu, R.M, Zhu, B. | 登録日 | 2021-08-25 | 公開日 | 2022-02-16 | 最終更新日 | 2022-03-16 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science, 375, 2022
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2FWZ
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2G8X
| Escherichia coli Y209W apoprotein | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CARBONATE ION, PHOSPHATE ION, ... | 著者 | Lee, T.T, Finer-Moore, J.S, Stroud, R.M. | 登録日 | 2006-03-03 | 公開日 | 2006-03-14 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | The role of protein dynamics in thymidylate synthase catalysis: Variants of conserved dUMP-binding Tyr-261 TO BE PUBLISHED
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2G86
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2G8D
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