4NEC

Conversion of a Disulfide Bond into a Thioacetal Group during Echinomycin Biosynthesis

Summary for 4NEC

• Entry DOI: 10.2210/pdb4nec/pdb
• Related PRD ID: PRD_000491
• Descriptor: Putative SAM-dependent methyltransferase, Echinomycin, S-ADENOSYL-L-HOMOCYSTEINE, ... (9 entities in total)
• Functional Keywords: methyltransferase, sam-dependent methyltransferase, transferase-antibiotic complex, transferase/antibiotic
• Biological source: Streptomyces lasaliensis; More
• Total number of polymer chains: 8
• Total formula weight: 123693.67

Authors

Hotta, K.,Keegan, R.M.,Ranganathan, S.,Fang, M.,Bibby, J.,Winn, M.D.,Sato, M.,Lian, M.,Watanabe, K.,Rigden, D.J.,Kim, C.-Y. (deposition date: 2013-10-29, release date: 2014-01-15, Last modification date: 2024-04-03)

• Primary citation: Hotta, K.,Keegan, R.M.,Ranganathan, S.,Fang, M.,Bibby, J.,Winn, M.D.,Sato, M.,Lian, M.,Watanabe, K.,Rigden, D.J.,Kim, C.Y.; Conversion of a disulfide bond into a thioacetal group during echinomycin biosynthesis.; Angew.Chem.Int.Ed.Engl., 53:824-828, 2014; PubMed: 24302672; DOI: 10.1002/anie.201307404

Experimental method

X-RAY DIFFRACTION (1.5 Å)