8WBY
| Cryo-EM structure of ACE2-B0AT1 complex with JX98 | Descriptor: | 2-(4-chloranyl-3,5-dimethyl-phenoxy)-~{N}-propan-2-yl-ethanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yan, R, Hu, Z, Dai, L. | Deposit date: | 2023-09-10 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Molecular basis of inhibition of the amino acid transporter B 0 AT1 (SLC6A19). Nat Commun, 15, 2024
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8WG4
| mouse TMEM63b in DDM-CHS micelle with YN9303-24 Fab | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL HEMISUCCINATE, CSC1-like protein 2,Green fluorescent protein | Authors: | Miyata, Y, Takahashi, K, Lee, Y, Sultan, C.S, Kuribayashi, R, Takahashi, M, Hata, K, Bamba, T, Izumi, Y, Liu, K, Uemura, T, Nomura, N, Iwata, S, Nagata, S, Nishizawa, T, Segawa, K. | Deposit date: | 2023-09-20 | Release date: | 2024-09-25 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Mechanosensitive channel TMEM63B functions as a plasma membrane lipid scramblase To Be Published
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8YTB
| Cryo-EM structure of enterovirus A71 empty particle | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3 | Authors: | Jiang, Y, Huang, Y, Zhu, R, Zheng, Q, Li, S, Xia, N. | Deposit date: | 2024-03-25 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Cryo-EM structure of enterovirus A71 empty particle To Be Published
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9DB5
| A DARPin fused to the 1TEL crystallization chaperone via a proline-alanine linker | Descriptor: | ACETIC ACID, CHLORIDE ION, SODIUM ION, ... | Authors: | Pedroza Romo, M.J, Averett, J.C, Keliiliki, A, Wilson, E.W, Smith, C, Hansen, D, Averett, B, Gonzalez, J, Noakes, E, Nickles, R, Doukov, T, Moody, J.D. | Deposit date: | 2024-08-23 | Release date: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Optimal TELSAM-Target Protein Linker Character is Target Protein Dependent To Be Published
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9BQ0
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9C6W
| Crystal Structure of a single chain trimer composed of HLA-B*39:06 Y84C variant, beta-2microglobulin, and NRVMLPKAA peptide from NLRP2 (2 molecules/asymmetric unit) | Descriptor: | 1,2-ETHANEDIOL, 3,6,9,12,15-PENTAOXAHEPTADECANE, CHLORIDE ION, ... | Authors: | Sharma, R, Amdare, N.P, Celikgil, A, Garforth, S.J, DiLorenzo, T.P, Almo, S.C, Ghosh, A. | Deposit date: | 2024-06-09 | Release date: | 2024-09-04 | Last modified: | 2024-10-02 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes. J.Biol.Chem., 300, 2024
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8WG1
| Crystal structure of GH97 glucodextranase mutant E509Q from Flavobacterium johnsoniae in complex with panose | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Candidate alpha-glucosidase Glycoside hydrolase family 97, ... | Authors: | Kurata, R, Nakamura, S, Miyazaki, T. | Deposit date: | 2023-09-20 | Release date: | 2024-05-08 | Last modified: | 2024-07-31 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Structural insights into alpha-(1→6)-linkage preference of GH97 glucodextranase from Flavobacterium johnsoniae. Febs J., 291, 2024
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9C5E
| Covalent Complex Between Parkin Catalytic (Rcat) Domain and Ubiquitin | Descriptor: | E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, ZINC ION | Authors: | Connelly, E.M, Rintala-Dempsey, A.C, Gundogdu, M, Freeman, E.A, Koszela, J, Aguirre, J.D, Zhu, G, Kamarainen, O, Tadayon, R, Walden, H, Shaw, G.S. | Deposit date: | 2024-06-06 | Release date: | 2024-08-14 | Last modified: | 2024-10-09 | Method: | SOLUTION NMR | Cite: | Capturing the catalytic intermediates of parkin ubiquitination. Proc.Natl.Acad.Sci.USA, 121, 2024
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8XW6
| Crystal structure of Streptococcus pneumoniae pyruvate kinase in complex with oxalate and fructose 1,6-bisphosphate and ATP | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Nakashima, R, Taguchi, A. | Deposit date: | 2024-01-16 | Release date: | 2024-07-31 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural Basis of Nucleotide Selectivity in Pyruvate Kinase. J.Mol.Biol., 436, 2024
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8ZLY
| Crystal structure of Streptococcus pneumoniae pyruvate kinase in complex with oxalate and fructose 1,6-bisphosphate and UDP | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, OXALATE ION, ... | Authors: | Nakashima, R, Taguchi, A. | Deposit date: | 2024-05-21 | Release date: | 2024-07-31 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural Basis of Nucleotide Selectivity in Pyruvate Kinase. J.Mol.Biol., 436, 2024
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8WZV
| SFX structure of an Mn-carbonyl complex immobilized in hen egg white lysozyme microcrystals, 1 microsecond after photoexcitation with 40 microJoules laser intensity at RT. | Descriptor: | CHLORIDE ION, Lysozyme C, SODIUM ION, ... | Authors: | Maity, B, Shoji, M, Luo, F, Nakane, T, Abe, S, Owada, S, Kang, J, Tono, K, Tanaka, R, Thuc, T.T, Kojima, M, Hishikawa, Y, Tanaka, J, Tian, J, Noya, H, Nakasuji, Y, Asanuma, A, Yao, X, Iwata, S, Shigeta, Y, Nango, E, Ueno, T. | Deposit date: | 2023-11-02 | Release date: | 2024-07-31 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Real-time observation of a metal complex-driven reaction intermediate using a porous protein crystal and serial femtosecond crystallography. Nat Commun, 15, 2024
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8XWP
| Cryo-EM structure of ET-1 bound ETBR-DNGI complex | Descriptor: | Endothelin receptor type B, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Tani, K, Maki-Yonekura, S, Kanno, R, Negami, T, Hamaguchi, T, Hall, M, Mizoguchi, A, Humbel, B.M, Terada, T, Yonekura, K, Doi, T. | Deposit date: | 2024-01-16 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Structure of endothelin ETB receptor-Gi complex in a conformation stabilized by the unique NPxxL motif Commun Biol, 2024
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5IA7
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8VLL
| Crystal structure of the yeast cytosine deaminase (yCD) M100W mutant | Descriptor: | 1,2-ETHANEDIOL, Cytosine deaminase, PHOSPHATE ION, ... | Authors: | Picard, M.-E, Grenier, J, Despres, P.C, Dube, A.K, Landry, C.R, Shi, R. | Deposit date: | 2024-01-11 | Release date: | 2024-08-21 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Compensatory mutations potentiate constructive neutral evolution by gene duplication. Science, 385, 2024
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2J9N
| Robotically harvested Trypsin complexed with Benzamidine containing polypeptide mediated crystal contacts | Descriptor: | BENZAMIDINE, CALCIUM ION, CATIONIC TRYPSIN, ... | Authors: | Viola, R, Carman, P, Walsh, J, Miller, E, Benning, M, Frankel, D, McPherson, A, Cudney, R, Rupp, B. | Deposit date: | 2006-11-14 | Release date: | 2007-04-03 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Operator Assisted Harvesting of Protein Crystals Using a Universal Micromanipulation Robot. J.Appl.Crystallogr., 40, 2007
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5IOF
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9B0E
| Cryo-EM Structure of E.coli produced recombinant N-acetyltransferase 10 (NAT10) in complex with cytidine-amide-CoA bisubstrate probe and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, RNA cytidine acetyltransferase, [[(2~{R},3~{S},4~{S},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{R})-4-[[3-[2-[2-[[1-[(2~{R},3~{S},4~{R},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-2-oxidanylidene-pyrimidin-4-yl]amino]-2-oxidanylidene-ethyl]sulfanylethylamino]-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate | Authors: | Zhou, M, Marmorstein, R. | Deposit date: | 2024-03-12 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Molecular Basis for RNA Cytidine Acetylation by NAT10. Biorxiv, 2024
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8VYX
| Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with k-410 | Descriptor: | 4,4'-[(1S,4S,5R)-5-(3,4-dihydroquinoline-1(2H)-sulfonyl)-7-oxabicyclo[2.2.1]hept-2-ene-2,3-diyl]diphenol, Estrogen receptor | Authors: | Min, C.K, Nwachukwu, J.C, Hou, Y, Russo, R.J, Papa, A, Min, J, Peng, R, Kim, S.H, Ziegler, Y, Rangarajan, E.S, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W. | Deposit date: | 2024-02-09 | Release date: | 2024-06-12 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu. Proc.Natl.Acad.Sci.USA, 121, 2024
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9FHE
| hKHK-C in complex with BI-9787 (pH 5.5) | Descriptor: | (2~{S})-3-[3-[[4-[bis(fluoranyl)methyl]-3-cyano-6-[(3~{S})-3-(dimethylamino)pyrrolidin-1-yl]pyridin-2-yl]amino]-4-methylsulfanyl-phenyl]-2-methyl-propanoic acid, Ketohexokinase | Authors: | Ebenhoch, R, Pautsch, A. | Deposit date: | 2024-05-27 | Release date: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.313 Å) | Cite: | Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability. Bioorg.Med.Chem.Lett., 112, 2024
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8WB3
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5ZJQ
| Structure of AbdB/Exd complex bound to a 'Red14' DNA sequence | Descriptor: | DNA (5'-D(*GP*CP*AP*TP*GP*AP*TP*TP*TP*AP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*TP*AP*AP*AP*TP*CP*AP*TP*GP*C)-3'), Homeobox protein abdominal-B, ... | Authors: | Baburajendran, N, Zeiske, T, Kaczynska, A, Mann, R, Honig, B, Shapiro, L, Palmer, A.G. | Deposit date: | 2018-03-22 | Release date: | 2018-08-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.443 Å) | Cite: | Intrinsic DNA Shape Accounts for Affinity Differences between Hox-Cofactor Binding Sites. Cell Rep, 24, 2018
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8VZQ
| Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with k-406 | Descriptor: | (1S,2R,4S)-N-(2-fluoro-2-methylpropyl)-5,6-bis(4-hydroxyphenyl)-N-(4-methoxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, Estrogen receptor, NICKEL (II) ION | Authors: | Min, C.K, Nwachukwu, J.C, Hou, Y, Russo, R.J, Papa, A, Min, J, Peng, R, Kim, S.H, Ziegler, Y, Rangarajan, E.S, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W. | Deposit date: | 2024-02-12 | Release date: | 2024-06-12 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu. Proc.Natl.Acad.Sci.USA, 121, 2024
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8WBZ
| Cryo-EM structure of ACE2-B0AT1 complex with JX225 | Descriptor: | 2-(4-bromanyl-3-methyl-phenoxy)-~{N}-propyl-ethanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yan, R, Hu, Z, Dai, L. | Deposit date: | 2023-09-10 | Release date: | 2024-09-11 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular basis of inhibition of the amino acid transporter B 0 AT1 (SLC6A19). Nat Commun, 15, 2024
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8WG0
| Crystal structure of GH97 glucodextranase from Flavobacterium johnsoniae in complex with glucose | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Candidate alpha-glucosidase Glycoside hydrolase family 97, ... | Authors: | Kurata, R, Nakamura, S, Miyazaki, T. | Deposit date: | 2023-09-20 | Release date: | 2024-05-08 | Last modified: | 2024-07-31 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural insights into alpha-(1→6)-linkage preference of GH97 glucodextranase from Flavobacterium johnsoniae. Febs J., 291, 2024
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8X35
| Neryl diphosphate synthase from Solanum lycopersicum complexed with DMSAPP, IPP, and magnesium ion (form A) | Descriptor: | 1,2-ETHANEDIOL, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | Authors: | Imaizumi, R, Matsuura, H, Yanai, T, Takeshita, K, Misawa, S, Yamaguchi, H, Sakai, N, Miyagi-Inoue, Y, Suenaga-Hiromori, M, Kataoka, K, Nakayama, T, Yamamoto, M, Takahashi, S, Yamashita, S. | Deposit date: | 2023-11-12 | Release date: | 2024-02-07 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural-Functional Correlations between Unique N-terminal Region and C-terminal Conserved Motif in Short-chain cis-Prenyltransferase from Tomato. Chembiochem, 25, 2024
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