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PDB: 27201 件

2Y37
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The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)
分子名称: 2-[(1R)-3-amino-1-phenyl-propoxy]-4-chloro-benzonitrile, 5,6,7,8-TETRAHYDROBIOPTERIN, GLYCEROL, ...
著者Cheshire, D.R, Andrews, G, Beaton, H.G, Birkinshaw, T.N, Boughton-Smith, N, Connolly, S, Cook, T.R, Cooper, A, Cooper, S.L, Cox, D, Dixon, J, Gensmantel, N, Hamley, P.J, Harrison, R, Hartopp, P, Kack, H, Luker, T, Mete, A, Millichip, I, Nicholls, D.J, Pimm, A.D, St-Gallay, S.A, Wallace, A.V.
登録日2010-12-19
公開日2011-04-13
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Discovery of Novel, Potent and Highly Selective Inhibitors of Inducible Nitric Oxide Synthase (Inos).
Bioorg.Med.Chem.Lett., 21, 2011
7X4K
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Cryo-EM structure of Coxsackievirus B1 empty particle in complex with nAb 9A3 (classified from CVB1 mature virion in complex with 8A10 and 9A3)
分子名称: 9A3 heavy chain, 9A3 light chain, Genome polyprotein, ...
著者Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N.
登録日2022-03-02
公開日2022-09-28
実験手法ELECTRON MICROSCOPY (3.82 Å)
主引用文献Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail.
Cell Host Microbe, 30, 2022
7X4M
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Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 8A10 (classified from CVB1 mature virion in complex with 8A10, 2E6 and 9A3)
分子名称: 8A10 heavy chain, 8A10 light chain, Capsid protein VP4, ...
著者Zheng, Q, Zhu, R, Sun, H, Cheng, T, Li, S, Xia, N.
登録日2022-03-02
公開日2022-09-28
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail.
Cell Host Microbe, 30, 2022
2Y51
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Crystal structure of E167A mutant of the box pathway encoded ALDH from Burkholderia xenovorans LB400
分子名称: ALDEHYDE DEHYDROGENASE (BOX PATHWAY), GLYCEROL
著者Bains, J, Leon, R, Temke, K.G, Boulanger, M.J.
登録日2011-01-11
公開日2011-06-01
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Elucidating the Reaction Mechanism of the Benzoate Oxidation Pathway Encoded Aldehyde Dehydrogenase from Burkholderia Xenovorans Lb400.
Protein Sci., 20, 2011
2Y48
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Crystal structure of LSD1-CoREST in complex with a N-terminal SNAIL peptide
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC DEMETHYLASE 1A, REST COREPRESSOR 1, ...
著者Baron, R, Binda, C, Tortorici, M, McCammon, J.A, Mattevi, A.
登録日2011-01-05
公開日2011-02-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase Lsd1-Corest Complex.
Structure, 19, 2011
2Y0I
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FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH TANKYRASE-2 (TNKS2) FRAGMENT PEPTIDE (21-MER)
分子名称: 2-OXOGLUTARIC ACID, FE (II) ION, GLYCEROL, ...
著者Chowdhury, R, McDonough, M.A, Schofield, C.J.
登録日2010-12-02
公開日2011-02-02
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
FEBS J., 278, 2011
2XVN
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A. fumigatus chitinase A1 phenyl-methylguanylurea complex
分子名称: 1-METHYL-3-(N-PHENYLCARBAMIMIDOYL)UREA, ASPERGILLUS FUMIGATUS CHITINASE A1, CHLORIDE ION
著者Rush, C.L, Schuttelkopf, A.W, Hurtado-Guerrero, R, Blair, D.E, Ibrahim, A.F.M, Desvergnes, S, Eggleston, I.M, van Aalten, D.M.F.
登録日2010-10-26
公開日2010-11-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Natural Product-Guided Discovery of a Fungal Chitinase Inhibitor.
Chem.Biol., 17, 2010
2XYP
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Caspase-3:CAS26049945
分子名称: CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17, PHENYLMETHYL N-[(2S)-4-CHLORO-3-OXO-1-PHENYL-BUTAN-2-YL]CARBAMATE
著者Ganesan, R, Jelakovic, S, Grutter, M.G, Mittl, P.R.
登録日2010-11-18
公開日2011-08-17
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献In Silico Identification and Crystal Structure Validation of Caspase-3 Inhibitors without a P1 Aspartic Acid Moiety.
Acta Crystallogr.,Sect.F, 67, 2011
3LLM
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Crystal Structure Analysis of a RNA Helicase
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase A, CACODYLATE ION, ...
著者Schutz, P, Karlberg, T, Collins, R, Arrowsmith, C.H, Berglund, H, Bountra, C, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kraulis, P, Kotenyova, T, Kotzsch, A, Markova, N, Moche, M, Nielsen, T.K, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Siponen, M.I, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H.M, Structural Genomics Consortium (SGC)
登録日2010-01-29
公開日2010-05-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein.
J.Mol.Biol., 400, 2010
2Y53
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Crystal structure of E257Q mutant of the box pathway encoded ALDH from Burkholderia xenovorans LB400
分子名称: ALDEHYDE DEHYDROGENASE (BOX PATHWAY), GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Bains, J, Leon, R, Temke, K.G, Boulanger, M.J.
登録日2011-01-11
公開日2011-06-01
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Elucidating the Reaction Mechanism of the Benzoate Oxidation Pathway Encoded Aldehyde Dehydrogenase from Burkholderia Xenovorans Lb400.
Protein Sci., 20, 2011
7WXM
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Crystal Structure of PL-5 family polysaccharide lyase PanPL from Pandoraea apista at pH6.5 in apo form
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, poly(beta-D-mannuronate) lyase
著者Dash, P, Acharya, R.
登録日2022-02-15
公開日2022-08-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.23 Å)
主引用文献Distinct Modes of Hidden Structural Dynamics in the Functioning of an Allosteric Polysaccharide Lyase.
Acs Cent.Sci., 8, 2022
7WXN
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Crystal Structure of PL-5 family polysaccharide lyase PanPL from Pandoraea apista at pH7.5 in apo form
分子名称: poly(beta-D-mannuronate) lyase
著者Dash, P, Acharya, R.
登録日2022-02-15
公開日2022-08-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Distinct Modes of Hidden Structural Dynamics in the Functioning of an Allosteric Polysaccharide Lyase.
Acs Cent.Sci., 8, 2022
7WXR
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Crystal Structure of PL-5 family polysaccharide lyase PanPL-N171L mutant from Pandoraea apista in apo form
分子名称: poly(beta-D-mannuronate) lyase
著者Dash, P, Acharya, R.
登録日2022-02-15
公開日2022-08-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Distinct Modes of Hidden Structural Dynamics in the Functioning of an Allosteric Polysaccharide Lyase.
Acs Cent.Sci., 8, 2022
7WXP
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Crystal Structure of PL-5 family polysaccharide lyase PanPL-H172A mutant from Pandoraea apista in ManA bound form
分子名称: beta-D-mannopyranuronic acid-(1-4)-beta-D-mannopyranuronic acid, poly(beta-D-mannuronate) lyase
著者Dash, P, Acharya, R.
登録日2022-02-15
公開日2022-08-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Distinct Modes of Hidden Structural Dynamics in the Functioning of an Allosteric Polysaccharide Lyase.
Acs Cent.Sci., 8, 2022
7WXL
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Crystal Structure of PL-5 family polysaccharide lyase PanPL from Pandoraea apista at pH5.5 in apo form
分子名称: CHLORIDE ION, poly(beta-D-mannuronate) lyase
著者Dash, P, Acharya, R.
登録日2022-02-15
公開日2022-08-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Distinct Modes of Hidden Structural Dynamics in the Functioning of an Allosteric Polysaccharide Lyase.
Acs Cent.Sci., 8, 2022
1DKH
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CRYSTAL STRUCTURE OF THE HEMOPHORE HASA, PH 6.5
分子名称: HEME-BINDING PROTEIN A, PROTOPORPHYRIN IX CONTAINING FE, SAMARIUM (III) ION, ...
著者Arnoux, P, Haser, R, Izadi-Pruneyre, N, Lecroisey, A, Czjzek, M.
登録日1999-12-07
公開日2000-12-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Functional aspects of the heme bound hemophore HasA by structural analysis of various crystal forms.
Proteins, 41, 2000
7WXO
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Crystal Structure of PL-5 family polysaccharide lyase PanPL from Pandoraea apista at pH8.5 in apo form
分子名称: poly(beta-D-mannuronate) lyase
著者Dash, P, Acharya, R.
登録日2022-02-15
公開日2022-08-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Distinct Modes of Hidden Structural Dynamics in the Functioning of an Allosteric Polysaccharide Lyase.
Acs Cent.Sci., 8, 2022
7WXQ
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Crystal Structure of PL-5 family polysaccharide lyase PanPL-H172A mutant from Pandoraea apista in apo form
分子名称: CHLORIDE ION, poly(beta-D-mannuronate) lyase
著者Dash, P, Acharya, R.
登録日2022-02-15
公開日2022-08-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Distinct Modes of Hidden Structural Dynamics in the Functioning of an Allosteric Polysaccharide Lyase.
Acs Cent.Sci., 8, 2022
7WXK
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Crystal Structure of PL-5 family polysaccharide lyase PanPL from Pandoraea apista at pH4.5 in apo form
分子名称: poly(beta-D-mannuronate) lyase
著者Dash, P, Acharya, R.
登録日2022-02-15
公開日2022-08-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Distinct Modes of Hidden Structural Dynamics in the Functioning of an Allosteric Polysaccharide Lyase.
Acs Cent.Sci., 8, 2022
7WXJ
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Crystal Structure of PL-5 family polysaccharide lyase PanPL from Pandoraea apista at pH3.5 in apo form
分子名称: poly(beta-D-mannuronate) lyase
著者Dash, P, Acharya, R.
登録日2022-02-15
公開日2022-08-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Distinct Modes of Hidden Structural Dynamics in the Functioning of an Allosteric Polysaccharide Lyase.
Acs Cent.Sci., 8, 2022
3KWJ
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Structure of human DPP-IV with (2S,3S,11bS)-3-(3-Fluoromethyl-phenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine
分子名称: (2S,3S,11bS)-3-[3-(fluoromethyl)phenyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4 soluble form
著者Hennig, M, Stihle, M, Thoma, R.
登録日2009-12-01
公開日2010-09-15
最終更新日2020-09-09
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
2V10
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Crystal Structure of Renin with Inhibitor 9
分子名称: (2R,4S,5S,7S)-5-AMINO-N-BUTYL-4-HYDROXY-7-[4-METHOXY-3-(3-METHOXYPROPOXY)BENZYL]-2,8-DIMETHYLNONANAMIDE, RENIN
著者Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G.
登録日2007-05-21
公開日2007-07-03
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin
Chem.Biol., 7, 2000
2VLA
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Crystal structure of restriction endonuclease BpuJI recognition domain in complex with cognate DNA
分子名称: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 5'-D(*GP*GP*TP*AP*CP*CP*CP*GP*TP*GP *GP*A)-3', 5'-D(*TP*CP*CP*AP*CP*GP*GP*GP*TP*AP *CP*C)-3', ...
著者Sukackaite, R, Grazulis, S, Bochtler, M, Siksnys, V.
登録日2008-01-11
公開日2008-05-06
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献The Recognition Domain of the Bpuji Restriction Endonuclease in Complex with Cognate DNA at 1.3-A Resolution.
J.Mol.Biol., 378, 2008
2OEP
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MSrecA-ADP-complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, Protein recA
著者Krishna, R, Rajan Prabu, J, Manjunath, G.P, Datta, S, Chandra, N.R, Muniyappa, K, Vijayan, M.
登録日2006-12-31
公開日2007-06-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Snapshots of RecA protein involving movement of the C-domain and different conformations of the DNA-binding loops: crystallographic and comparative analysis of 11 structures of Mycobacterium smegmatis RecA
J.Mol.Biol., 367, 2007
7XUZ
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Crystal structure of a HDAC4-MEF2A-DNA ternary complex
分子名称: DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3'), Histone deacetylase 4, ...
著者Dai, S.Y, Guo, L, Dey, R, Guo, M, Bates, D, Cayford, J, Chen, X.J, Wei, X.D, Chen, L, Chen, Y.H.
登録日2022-05-20
公開日2023-11-29
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (3.591 Å)
主引用文献Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.
Nucleic Acids Res., 52, 2024

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件を2024-07-17に公開中

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