3KWJ
Structure of human DPP-IV with (2S,3S,11bS)-3-(3-Fluoromethyl-phenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine
Summary for 3KWJ
Entry DOI | 10.2210/pdb3kwj/pdb |
Related | 1NU6 1NU8 3KWF 3KWH |
Descriptor | Dipeptidyl peptidase 4 soluble form, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2S,3S,11bS)-3-[3-(fluoromethyl)phenyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine, ... (4 entities in total) |
Functional Keywords | diabetes type ii, aminopeptidase, cell membrane, disulfide bond, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 170550.99 |
Authors | Hennig, M.,Stihle, M.,Thoma, R. (deposition date: 2009-12-01, release date: 2010-09-15, Last modification date: 2020-09-09) |
Primary citation | Boehringer, M.,Fischer, H.,Hennig, M.,Hunziker, D.,Huwyler, J.,Kuhn, B.,Loeffler, B.M.,Luebbers, T.,Mattei, P.,Narquizian, R.,Sebokova, E.,Sprecher, U.,Wessel, H.P. Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors. Bioorg.Med.Chem.Lett., 20:1106-1108, 2010 Cited by PubMed: 20031408DOI: 10.1016/j.bmcl.2009.12.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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