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PDB: 27201 件
4RQ1
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Human DNA Polymerase Beta With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine(8-oxoG) and dCTP soaked with MgCl2 for 1hr
分子名称: ACETATE ION, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3'), ...
著者Vyas, R, Suo, Z.
登録日2014-10-31
公開日2015-04-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Viewing Human DNA Polymerase beta Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography.
J.Am.Chem.Soc., 137, 2015
4RRK
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Y115A mutant of N-terminal editing domain of threonyl-tRNA synthetase from Aeropyrum pernix with L-Thr3AA
分子名称: 3'-deoxy-3'-(L-threonylamino)adenosine, MAGNESIUM ION, Probable threonine--tRNA ligase 2
著者Ahmad, S, Muthukumar, S, Sankaranarayanan, R.
登録日2014-11-06
公開日2015-07-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Specificity and catalysis hardwired at the RNA-protein interface in a translational proofreading enzyme.
Nat Commun, 6, 2015
4RRP
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BU of 4rrp by Molmil
Crystal Structure of the Fab complexed with antigen Asf1p, Northeast Structural Genomics Consortium (NESG) Target PdR16
分子名称: Antigen Asf1p, DI(HYDROXYETHYL)ETHER, Fab antibody, ...
著者Kuzin, A, Lew, S, Seetharaman, J, Mao, L, Xiao, R, Oconnell, P.T, Maglaqui, M, Bailey, L, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS), Northeast Structural Genomics Consortium (NESG)
登録日2014-11-06
公開日2014-12-31
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Crystal Structure of the Fab complexed with antigen Asf1p, Northeast Structural Genomics Consortium (NESG) Target PdR16
To be Published
7L99
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BU of 7l99 by Molmil
Crystal structure of BRDT bromodomain 2 in complex with CDD-1302
分子名称: Bromodomain testis-specific protein, N-[3-(acetylamino)-4-methylphenyl]-3-(4-amino-2-methylphenyl)-1-methyl-1H-indazole-5-carboxamide, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500)
著者Sharma, R, Yu, Z, Ku, A.F, Anglin, J.L, Ucisik, M.N, Faver, J.C, Sankaran, B, Kim, C, Matzuk, M.M.
登録日2021-01-03
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.
Proc.Natl.Acad.Sci.USA, 118, 2021
5NN3
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Crystal structure of human lysosomal acid-alpha-glucosidase, GAA
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Roig-Zamboni, V, Cobucci-Ponzano, B, Iacono, R, Ferrara, M.C, Germany, S, Parenti, G, Bourne, Y, Moracci, M.
登録日2017-04-08
公開日2017-10-25
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of human lysosomal acid alpha-glucosidase-a guide for the treatment of Pompe disease.
Nat Commun, 8, 2017
4TOE
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BU of 4toe by Molmil
2.20A resolution structure of Iron Bound BfrB (D34F) from Pseudomonas aeruginosa
分子名称: Bacterioferritin, FE (II) ION, POTASSIUM ION, ...
著者Lovell, S, Battaile, K.P, Yao, H, Kumar, R, Eshelman, K, Rivera, M.
登録日2014-06-05
公開日2015-02-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Concerted motions networking pores and distant ferroxidase centers enable bacterioferritin function and iron traffic.
Biochemistry, 54, 2015
4RWD
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BU of 4rwd by Molmil
XFEL structure of the human delta opioid receptor in complex with a bifunctional peptide
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, OLEIC ACID, SODIUM ION, ...
著者Fenalti, G, Zatsepin, N.A, Betti, C, Giguere, P, Han, G.W, Ishchenko, A, Liu, W, Guillemyn, K, Zhang, H, James, D, Wang, D, Weierstall, U, Spence, J.C.H, Boutet, S, Messerschmidt, M, Williams, G.J, Gati, C, Yefanov, O.M, White, T.A, Oberthuer, D, Metz, M, Yoon, C.H, Barty, A, Chapman, H.N, Basu, S, Coe, J, Conrad, C.E, Fromme, R, Fromme, P, Tourwe, D, Schiller, P.W, Roth, B.L, Ballet, S, Katritch, V, Stevens, R.C, Cherezov, V, GPCR Network (GPCR)
登録日2014-12-02
公開日2015-01-14
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for bifunctional peptide recognition at human delta-opioid receptor.
Nat.Struct.Mol.Biol., 22, 2015
4RWQ
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Crystal structure of the apo-state of porcine OAS1
分子名称: 2'-5'-oligoadenylate synthase 1
著者Lohoefener, J, Steinke, N, Kay-Fedorov, P, Baruch, P, Nikulin, A, Tishchenko, S, Manstein, D.J, Fedorov, R.
登録日2014-12-05
公開日2015-05-20
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity.
Structure, 23, 2015
7L9A
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BU of 7l9a by Molmil
Crystal structure of BRDT bromodomain 2 in complex with CDD-1102
分子名称: BETA-MERCAPTOETHANOL, Bromodomain testis-specific protein, N~1~-(5-{[3-(4-amino-2-methylphenyl)-1-methyl-1H-indazole-5-carbonyl]amino}-2-methylphenyl)-N~4~-methylbenzene-1,4-dicarboxamide
著者Sharma, R, Kaur, G, Yu, Z, Ku, A.F, Anglin, J.L, Ucisik, M.N, Faver, J.C, Sankaran, B, Kim, C, Matzuk, M.M.
登録日2021-01-03
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.
Proc.Natl.Acad.Sci.USA, 118, 2021
7LM3
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BU of 7lm3 by Molmil
Crystal Structure of Thr316Ala mutant of JAMM domain of S. pombe
分子名称: AMSH-like protease sst2, PHOSPHATE ION, ZINC ION
著者Shrestha, R, Das, C.
登録日2021-02-05
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of the Thr316Ala mutant of a yeast JAMM deubiquitinase: implication of active-site loop dynamics in catalysis.
Acta Crystallogr.,Sect.F, 77, 2021
7LXD
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BU of 7lxd by Molmil
Structure of yeast DNA Polymerase Zeta (apo)
分子名称: DNA polymerase delta small subunit, DNA polymerase delta subunit 3, DNA polymerase zeta catalytic subunit, ...
著者Truong, C.D, Craig, T.A, Cui, G, Botuyan, M.V, Serkasevich, R.A, Chan, K.-Y, Mer, G, Chiu, P.-L, Kumar, R.
登録日2021-03-03
公開日2021-06-30
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.11 Å)
主引用文献Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta.
J.Biol.Chem., 297, 2021
4RZB
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BU of 4rzb by Molmil
The structure of N-formimino-L-Glutamate Iminohydrolase from Pseudomonas aeruginosa complexed with N-formimino-L-Aspartate, SOAKED WITH MERCURY
分子名称: GLYCEROL, MERCURY (II) ION, N-[(E)-iminomethyl]-L-aspartic acid, ...
著者Fedorov, A.A, Fedorov, E.V, Marti-Arbona, R, Raushel, F.M, Almo, S.C.
登録日2014-12-19
公開日2015-01-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.863 Å)
主引用文献Structure of N-Formimino-l-glutamate Iminohydrolase from Pseudomonas aeruginosa.
Biochemistry, 54, 2015
5CR2
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BU of 5cr2 by Molmil
E. coli MazF in complex with single strand DNA substrate analog
分子名称: Endoribonuclease MazF, ssDNA substrate analog
著者Zorzini, V, Loris, R.
登録日2015-07-22
公開日2016-04-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Substrate Recognition and Activity Regulation of the Escherichia coli mRNA Endonuclease MazF.
J.Biol.Chem., 291, 2016
5CUB
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BU of 5cub by Molmil
Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 314268-40-1 (SGC - Diamond I04-1 fragment screening)
分子名称: 1,2-ETHANEDIOL, Bromodomain adjacent to zinc finger domain protein 2B, methyl 4-[(4-methylpiperazin-1-yl)methyl]benzoate
著者Bradley, A, Pearce, N, Krojer, T, Ng, J, Talon, R, Vollmar, M, Jose, B, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC)
登録日2015-07-24
公開日2015-09-09
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 314268-40-1 (SGC - Diamond I04-1 fragment screening)
To be published
5CUG
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BU of 5cug by Molmil
Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 4-Acetamidobenzoic acid (SGC - Diamond I04-1 fragment screening)
分子名称: 1,2-ETHANEDIOL, Bromodomain adjacent to zinc finger domain protein 2B, PARA ACETAMIDO BENZOIC ACID
著者Bradley, A, Pearce, N, Krojer, T, Ng, J, Talon, R, Vollmar, M, Jose, B, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC)
登録日2015-07-24
公開日2015-09-09
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 4-Acetamidobenzoic acid (SGC - Diamond I04-1 fragment screening)
To be published
5M8A
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BU of 5m8a by Molmil
Crystal structure of Eremococcus coleocola manganese transporter mutant E129A
分子名称: Divalent metal cation transporter MntH
著者Manatschal, C, Ehrnstorfer, I.A, Arnold, F.M, Laederach, J, Dutzler, R.
登録日2016-10-28
公開日2017-01-11
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Structural and mechanistic basis of proton-coupled metal ion transport in the SLC11/NRAMP family.
Nat Commun, 8, 2017
4RQ7
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Human DNA Polymerase Beta With Gapped DNA Containing an 8-oxo-7,8-dihydro-Guanine (8-oxoG)and dATP soaked with MgCl2 for 1hr
分子名称: ACETATE ION, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
著者Vyas, R, Reed, A.J, Suo, Z.
登録日2014-10-31
公開日2015-04-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Viewing Human DNA Polymerase beta Faithfully and Unfaithfully Bypass an Oxidative Lesion by Time-Dependent Crystallography.
J.Am.Chem.Soc., 137, 2015
4RRC
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BU of 4rrc by Molmil
N-terminal editing domain of threonyl-tRNA synthetase from Aeropyrum pernix with L-Thr3AA (snapshot 3)
分子名称: 3'-deoxy-3'-(L-threonylamino)adenosine, Probable threonine--tRNA ligase 2
著者Ahmad, S, Muthukumar, S, Yerabham, A.S.K, Kamarthapu, V, Sankaranarayanan, R.
登録日2014-11-06
公開日2015-07-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Specificity and catalysis hardwired at the RNA-protein interface in a translational proofreading enzyme.
Nat Commun, 6, 2015
4RRO
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8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors
分子名称: (4S,4a'R,10a'S)-2-amino-8'-(2-fluoropyridin-3-yl)-1,4a'-dimethyl-3',4',4a',10a'-tetrahydro-2'H-spiro[imidazole-4,10'-pyrano[3,2-b]chromen]-5(1H)-one, Beta-secretase 1, NICKEL (II) ION
著者Thomas, A.A, Hunt, K.W, Newhouse, B, Watts, R.J, Liu, X, Vigers, G.P.A, Smith, D, Rhodes, S.P, Brown, K.D, Otten, J.N, Burkard, M, Cox, A.A, Geck Do, M.K, Dutcher, D, Rana, S, DeLisle, R.K, Regal, K, Wright, A.D, Groneberg, R, Liao, J, Scearce-Levie, K, Siu, M, Purkey, H.E, Lyssikatos, J.P.
登録日2014-11-06
公開日2014-12-03
最終更新日2014-12-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献8-Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors.
J.Med.Chem., 57, 2014
4RT5
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The crystal structure of a glyoxalase/bleomycin resistance protein/dioxygenase protein from planctomyces limnophilus dsm 3776
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Glyoxalase/bleomycin resistance protein/dioxygenase, ...
著者Wu, R, Bearden, J, Kim, Y, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
登録日2014-11-13
公開日2014-12-03
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The crystal structure of a glyoxalase/bleomycin resistance protein/dioxygenase protein from Planctomyces limnophilus dsm 3776
TO BE PUBLISHED
4RUK
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BU of 4ruk by Molmil
crystal structure of Phosphoapantetheine adenylyltransferase PPAT/CoaD with CoA and pyrophosphate from Pseudomonas aeruginosa
分子名称: ACETATE ION, CALCIUM ION, COENZYME A, ...
著者Chatterjee, R, Datta, S.
登録日2014-11-20
公開日2015-11-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Transition of phosphopantetheine adenylyltransferase from catalytic to allosteric state is characterized by ternary complex formation in Pseudomonas aeruginosa
Biochim.Biophys.Acta, 1864, 2016
4RUZ
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BU of 4ruz by Molmil
Crystal structure of human Carbonic Anhydrase II in complex with 4-ethoxybenzenesulfonamide
分子名称: 4-ethoxybenzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ...
著者Pinard, M.A, Mckenna, R.
登録日2014-11-23
公開日2015-04-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.
Bioorg.Med.Chem., 23, 2015
7M5F
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BU of 7m5f by Molmil
Contact-dependent inhibition system from Serratia marcescens BWH57
分子名称: CdiI, MALONATE ION, Toxin CdiA
著者Michalska, K, Nutt, W, Stols, L, Jedrzejczak, R, Hayes, C.S, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2021-03-23
公開日2021-05-12
最終更新日2021-08-18
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Contact-dependent inhibition system from Serratia marcescens
To Be Published
4TN1
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Translation initiation factor eIF5B (517-858) mutant D533R from C. thermophilum, bound to GTPgammaS
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, eIF5B
著者Kuhle, B, Ficner, R.
登録日2014-06-02
公開日2014-09-24
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献A monovalent cation acts as structural and catalytic cofactor in translational GTPases.
Embo J., 33, 2014
5MP3
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Crystal structure of DC8E8 Fab in the complex with a 30-mer tau peptide at pH 6.5
分子名称: ENSMUSG00000076577 protein, Igh protein, Microtubule-associated protein
著者Skrabana, R, Novak, M, Cehlar, O, Kontsekova, E.
登録日2016-12-15
公開日2018-05-02
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Crystal structure of DC8E8 Fab in the complex with a 30-mer tau peptide at pH 6.5
To be published

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件を2024-07-17に公開中

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