6YVT
| HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with MD-253 | 分子名称: | 2-[[5-(6-methoxynaphthalen-2-yl)-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, Egl nine homolog 1, GLYCEROL, ... | 著者 | Chowdhury, R, Demetriades, M, Schofield, C.J. | 登録日 | 2020-04-28 | 公開日 | 2020-05-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.847 Å) | 主引用文献 | Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors. Angew.Chem.Int.Ed.Engl., 51, 2012
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8K5W
| Crystal structure of human proMMP-9 catalytic domain in complex with inhibitor | 分子名称: | 2-[[5-fluoranyl-7-(methylamino)-1H-indol-2-yl]carbonyl]-N-(2-pyrrol-1-ylethyl)-3,4-dihydro-1H-isoquinoline-7-carboxamide, CALCIUM ION, DIHYDROGENPHOSPHATE ION, ... | 著者 | Kamitani, M, Mima, M, Nishikawa-Shimono, R. | 登録日 | 2023-07-24 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation. Bioorg.Med.Chem.Lett., 97, 2023
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3BAK
| N298S mutant of Human Pancreatic Alpha-Amylase in complex with nitrate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NITRATE ION, ... | 著者 | Fredriksen, J.R, Maurus, R, Brayer, G.D. | 登録日 | 2007-11-08 | 公開日 | 2008-03-25 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Alternative catalytic anions differentially modulate human alpha-amylase activity and specificity Biochemistry, 47, 2008
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6Z8X
| X-ray structure of the complex between human alpha thrombin and a thrombin binding aptamer variant (TBA-3Leu), which contains leucyl amide in the side chain of Thy3 at N3. | 分子名称: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, POTASSIUM ION, Prothrombin, ... | 著者 | Troisi, R, Timofeev, E.N, Sica, F. | 登録日 | 2020-06-02 | 公開日 | 2021-01-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12. Mol Ther Nucleic Acids, 23, 2021
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6Z1Q
| MAP3K14 (NIK) in complex with DesF-3R/4076 | 分子名称: | DesF-3R/4076, Mitogen-activated protein kinase kinase kinase 14 | 著者 | Jacoby, E, van Vlijmen, H, Querolle, O, Stansfield, I, Meerpoel, L, Versele, M, Hynd, G, Attar, R. | 登録日 | 2020-05-14 | 公開日 | 2020-07-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | FEP+ calculations predict a stereochemical SAR switch for first-in-class indoline NIK inhibitors for multiple myeloma Future Drug Discov, 2, 2020
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7OO2
| Crystal structure of an antibody targeting the capsular polysaccharide of serogroup X Neisseria meningitidis (MenX) | 分子名称: | THIOCYANATE ION, anti-MenX Fab heavy chain, anti-MenX Fab light chain | 著者 | Pietri, G.P, de Ruyck, J, Lenac, T, Adamo, R, Bouckaert, J. | 登録日 | 2021-05-26 | 公開日 | 2021-10-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Elucidating the Structural and Minimal Protective Epitope of the Serogroup X Meningococcal Capsular Polysaccharide. Front Mol Biosci, 8, 2021
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8K5V
| Crystal structure of human proMMP-9 catalytic domain in complex with inhibitor | 分子名称: | 6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl-(7-ethyl-2H-indazol-3-yl)methanone, CALCIUM ION, DIHYDROGENPHOSPHATE ION, ... | 著者 | Kamitani, M, Mima, M, Nishikawa-Shimono, R. | 登録日 | 2023-07-24 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation. Bioorg.Med.Chem.Lett., 97, 2023
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8K5Y
| Crystal structure of human proMMP-9 catalytic domain in complex with inhibitor | 分子名称: | (3-azanyl-4-fluoranyl-5,7,8,9-tetrahydropyrido[4,3-c]azepin-6-yl)-[6-(2-oxidanylpropan-2-yl)-1H-indol-2-yl]methanone, CALCIUM ION, DIHYDROGENPHOSPHATE ION, ... | 著者 | Kamitani, M, Mima, M, Nishikawa-Shimono, R. | 登録日 | 2023-07-24 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation. Bioorg.Med.Chem.Lett., 97, 2023
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8K5X
| Crystal structure of human proMMP-9 catalytic domain in complex with inhibitor | 分子名称: | (6-cyclopropyl-1~{H}-indol-2-yl)-(5,7,8,9-tetrahydropyrido[4,3-c]azepin-6-yl)methanone, CALCIUM ION, CHLORIDE ION, ... | 著者 | Kamitani, M, Mima, M, Nishikawa-Shimono, R. | 登録日 | 2023-07-24 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation. Bioorg.Med.Chem.Lett., 97, 2023
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8OIF
| Structure of the UBE1L activating enzyme bound to ISG15 and UBE2L6 | 分子名称: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | 著者 | Wallace, I, Kheewoong, B, Prabu, J.R, Vollrath, R, von Gronau, S, Schulman, B.A, Swatek, K.N. | 登録日 | 2023-03-22 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Insights into the ISG15 transfer cascade by the UBE1L activating enzyme. Nat Commun, 14, 2023
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3JDW
| CRYSTAL STRUCTURE AND MECHANISM OF L-ARGININE: GLYCINE AMIDINOTRANSFERASE: A MITOCHONDRIAL ENZYME INVOLVED IN CREATINE BIOSYNTHESIS | 分子名称: | L-ARGININE:GLYCINE AMIDINOTRANSFERASE, L-ornithine | 著者 | Humm, A, Fritsche, E, Steinbacher, S, Huber, R. | 登録日 | 1997-01-24 | 公開日 | 1998-01-28 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis. EMBO J., 16, 1997
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6TD4
| IRF4 DNA-binding domain surface entropy mutant apo structure | 分子名称: | CHLORIDE ION, Interferon regulatory factor 4 | 著者 | Tucker, J.A, Martin, M.P, Wang, L.Z, Jennings, C, Heath, R. | 登録日 | 2019-11-07 | 公開日 | 2020-11-18 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Cancer-associated mutations in the IRF4 DNA-binding domain confer no disadvantage in DNA-binding affinity and may increase transcriptional activity To Be Published
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1OVO
| CRYSTALLOGRAPHIC REFINEMENT OF JAPANESE QUAIL OVOMUCOID, A KAZAL-TYPE INHIBITOR, AND MODEL BUILDING STUDIES OF COMPLEXES WITH SERINE PROTEASES | 分子名称: | OVOMUCOID THIRD DOMAIN | 著者 | Weber, E, Papamokos, E, Bode, W, Huber, R, Kato, I, Laskowskijunior, M. | 登録日 | 1982-01-18 | 公開日 | 1982-05-26 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystallographic refinement of Japanese quail ovomucoid, a Kazal-type inhibitor, and model building studies of complexes with serine proteases. J.Mol.Biol., 158, 1982
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1PUD
| TRNA-GUANINE TRANSGLYCOSYLASE | 分子名称: | TRNA-GUANINE TRANSGLYCOSYLASE, ZINC ION | 著者 | Romier, C, Reuter, K, Suck, D, Ficner, R. | 登録日 | 1996-06-28 | 公開日 | 1997-07-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange. EMBO J., 15, 1996
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8OFE
| E.coli Peptide Deformylase with bound inhibitor | 分子名称: | (2R)-2-[[methanoyl(oxidanyl)amino]methyl]-N-[(2S)-3-methyl-1-oxidanylidene-1-[2-(sulfanylmethyl)pyrrolidin-1-yl]butan-2-yl]heptanamide, Peptide deformylase, ZINC ION | 著者 | Kirschner, H, Stoll, R, Hofmann, E. | 登録日 | 2023-03-15 | 公開日 | 2023-12-27 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural Insights into Antibacterial Payload Release from Gold Nanoparticles Bound to E. coli Peptide Deformylase. Chemmedchem, 19, 2024
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7OTL
| Structure of a psychrophilic CCA-adding enzyme crystallized by counter-diffusion | 分子名称: | CCA-adding enzyme, SULFATE ION | 著者 | Rollet, K, de Wijn, R, Hennig, O, Betat, H, Moerl, M, Lorber, B, Sauter, C. | 登録日 | 2021-06-10 | 公開日 | 2021-11-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | CCA-addition in the cold: Structural characterization of the psychrophilic CCA-adding enzyme from the permafrost bacterium Planococcus halocryophilus . Comput Struct Biotechnol J, 19, 2021
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8OMK
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7OQX
| Crystal structure of a psychrophilic CCA-adding enzyme in complex with CMPcPP | 分子名称: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ACETATE ION, CCA-adding enzyme, ... | 著者 | Rollet, K, de Wijn, R, Bluhm, A, Hennig, O, Betat, H, Moerl, M, Lorber, B, Sauter, C. | 登録日 | 2021-06-04 | 公開日 | 2021-11-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | CCA-addition in the cold: Structural characterization of the psychrophilic CCA-adding enzyme from the permafrost bacterium Planococcus halocryophilus . Comput Struct Biotechnol J, 19, 2021
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8OPX
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6TIR
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8OPU
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8OPW
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8OPY
| Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with Fragment-B-DNQ | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase, 6,7-DINITROQUINOXALINE-2,3-DIONE, GLYCEROL, ... | 著者 | Dalwani, S, Wierenga, R.K, Venkatesan, R. | 登録日 | 2023-04-10 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Crystallographic fragment binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate channeling path between them Biorxiv, 2024
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8K8E
| Human gamma-secretase in complex with a substrate mimetic | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Shi, Y.G, Zhou, R, Wolfe, M.S. | 登録日 | 2023-07-29 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Familial Alzheimer mutations stabilize synaptotoxic gamma-secretase-substrate complexes. Cell Rep, 43, 2024
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8OH8
| Crystal structure of the cysteine-rich Gallus gallus urate oxidase in complex with the 8-azaxanthine inhibitor under reducing conditions (space group P 21 21 21) | 分子名称: | 1,2-ETHANEDIOL, 8-AZAXANTHINE, CHLORIDE ION, ... | 著者 | Di Palma, M, Chegkazi, M, Bui, S, Mori, G, Percudani, R, Steiner, R.A. | 登録日 | 2023-03-20 | 公開日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Cysteine Enrichment Mediates Co-Option of Uricase in Reptilian Skin and Transition to Uricotelism. Mol.Biol.Evol., 40, 2023
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