6Z8X

X-ray structure of the complex between human alpha thrombin and a thrombin binding aptamer variant (TBA-3Leu), which contains leucyl amide in the side chain of Thy3 at N3.

Summary for 6Z8X

• Entry DOI: 10.2210/pdb6z8x/pdb
• Related: 6Z8V 6Z8W
• Descriptor: Prothrombin, TBA-3Leu, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (7 entities in total)
• Functional Keywords: modified aptamer, dna-protein complex, anticoaugulant, g-quadruplex, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 39190.96

Authors

Troisi, R.,Timofeev, E.N.,Sica, F. (deposition date: 2020-06-02, release date: 2021-01-27, Last modification date: 2024-01-24)

• Primary citation: Smirnov, I.,Kolganova, N.,Troisi, R.,Sica, F.,Timofeev, E.; Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12.; Mol Ther Nucleic Acids, 23:863-871, 2021; PubMed: 33614235; DOI: 10.1016/j.omtn.2021.01.004

Experimental method

X-RAY DIFFRACTION (2.53 Å)