6Z8X
X-ray structure of the complex between human alpha thrombin and a thrombin binding aptamer variant (TBA-3Leu), which contains leucyl amide in the side chain of Thy3 at N3.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| H | 0004252 | molecular_function | serine-type endopeptidase activity |
| H | 0005509 | molecular_function | calcium ion binding |
| H | 0006508 | biological_process | proteolysis |
| H | 0007596 | biological_process | blood coagulation |
| L | 0004252 | molecular_function | serine-type endopeptidase activity |
| L | 0005576 | cellular_component | extracellular region |
| L | 0006508 | biological_process | proteolysis |
| L | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue 0G6 H 301 |
| Chain | Residue |
| H | HIS57 |
| H | SER195 |
| H | SER214 |
| H | TRP215 |
| H | GLY216 |
| H | GLY219 |
| H | GLY226 |
| H | TYR60 |
| H | TRP60 |
| H | LEU99 |
| H | ASP189 |
| H | ALA190 |
| H | CYS191 |
| H | GLU192 |
| H | GLY193 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue NA H 302 |
| Chain | Residue |
| H | TYR184 |
| H | GLY188 |
| H | ARG221 |
| H | LYS224 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue K B 201 |
| Chain | Residue |
| B | DG1 |
| B | DG2 |
| B | DG5 |
| B | DG6 |
| B | DG10 |
| B | DG11 |
| B | DG14 |
| B | DG15 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Region: {"description":"High affinity receptor-binding region which is also known as the TP508 peptide"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"873923","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
