6YVT

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with MD-253

Summary for 6YVT

Entry DOI	10.2210/pdb6yvt/pdb
Related	4BQW 4BQX 4BQY 5A3U
Descriptor	Egl nine homolog 1, MANGANESE (II) ION, 2-[[5-(6-methoxynaphthalen-2-yl)-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, ... (6 entities in total)
Functional Keywords	oxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex
Biological source	Homo sapiens (Human)
Total number of polymer chains	6
Total formula weight	171213.48
Authors	Chowdhury, R.,Demetriades, M.,Schofield, C.J. (deposition date: 2020-04-28, release date: 2020-05-20, Last modification date: 2024-01-24)
Primary citation	Demetriades, M.,Leung, I.K.,Chowdhury, R.,Chan, M.C.,McDonough, M.A.,Yeoh, K.K.,Tian, Y.M.,Claridge, T.D.,Ratcliffe, P.J.,Woon, E.C.,Schofield, C.J. Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors. Angew.Chem.Int.Ed.Engl., 51:6672-6675, 2012 Cited by PubMed: 22639232 DOI: 10.1002/anie.201202000 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.847 Å)

Structure validation