6YVT

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with MD-253

Summary for 6YVT

• Entry DOI: 10.2210/pdb6yvt/pdb
• Related: 4BQW 4BQX 4BQY 5A3U
• Descriptor: Egl nine homolog 1, MANGANESE (II) ION, 2-[[5-(6-methoxynaphthalen-2-yl)-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, ... (6 entities in total)
• Functional Keywords: oxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 171213.48

Authors

Chowdhury, R.,Demetriades, M.,Schofield, C.J. (deposition date: 2020-04-28, release date: 2020-05-20, Last modification date: 2024-01-24)

• Primary citation: Demetriades, M.,Leung, I.K.,Chowdhury, R.,Chan, M.C.,McDonough, M.A.,Yeoh, K.K.,Tian, Y.M.,Claridge, T.D.,Ratcliffe, P.J.,Woon, E.C.,Schofield, C.J.; Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.; Angew.Chem.Int.Ed.Engl., 51:6672-6675, 2012; PubMed: 22639232; DOI: 10.1002/anie.201202000

Experimental method

X-RAY DIFFRACTION (2.847 Å)