6YVT
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with MD-253
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Egl nine homolog 1 | polymer | 252 | 28096.9 | 6 | UniProt (Q9GZT9) Pfam (PF13640) | Homo sapiens (Human) | Hypoxia-inducible factor prolyl hydroxylase 2,HPH-2,Prolyl hydroxylase domain-containing protein 2,PHD2,SM-20 |
| 2 | G, I, K, M, O... (A, B, C, D, E...) | MANGANESE (II) ION | non-polymer | 54.9 | 6 | Chemie (MN) | |||
| 3 | H, J, L, N, P... (A, B, C, D, E...) | 2-[[5-(6-methoxynaphthalen-2-yl)-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid | non-polymer | 352.3 | 6 | Chemie (PW2) | |||
| 4 | Q (E) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | R (E) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | U, V, W, X, Y... (A, B, C, D, E...) | water | water | 18.0 | 57 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 181 - 426 (UniProt: Q9GZT9)
| PDB | External Database | Details |
|---|---|---|
| Gly 175 | - | expression tag |
| Ser 176 | - | expression tag |
| His 177 | - | expression tag |
| Met 178 | - | expression tag |
| Ala 179 | - | expression tag |
| Ser 180 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 168581.6 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 2631.8 | |
| All* | Total formula weight | 171213.5 |
