6YVT
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with MD-253
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Egl nine homolog 1 | polymer | 252 | 28096.9 | 6 | UniProt (Q9GZT9) Pfam (PF13640) In PDB | Homo sapiens (Human) | Hypoxia-inducible factor prolyl hydroxylase 2,HPH-2,Prolyl hydroxylase domain-containing protein 2,PHD2,SM-20 |
2 | A, B, C, D, E... | MANGANESE (II) ION | non-polymer | 54.9 | 6 | Chemie (MN) | |||
3 | A, B, C, D, E... | 2-[[5-(6-methoxynaphthalen-2-yl)-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid | non-polymer | 352.3 | 6 | Chemie (PW2) | |||
4 | E | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | E | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
6 | water | water | 18.0 | 57 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 181 - 426 (UniProt: Q9GZT9)
PDB | External Database | Details |
---|---|---|
Gly 175 | - | expression tag |
Ser 176 | - | expression tag |
His 177 | - | expression tag |
Met 178 | - | expression tag |
Ala 179 | - | expression tag |
Ser 180 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 168581.6 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 2631.8 | |
All* | Total formula weight | 171213.5 |