6YVT
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with MD-253
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0031418 | molecular_function | L-ascorbic acid binding |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0031418 | molecular_function | L-ascorbic acid binding |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| C | 0031418 | molecular_function | L-ascorbic acid binding |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| D | 0031418 | molecular_function | L-ascorbic acid binding |
| E | 0005506 | molecular_function | iron ion binding |
| E | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| E | 0031418 | molecular_function | L-ascorbic acid binding |
| F | 0005506 | molecular_function | iron ion binding |
| F | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| F | 0031418 | molecular_function | L-ascorbic acid binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 501 |
| Chain | Residue |
| A | HIS313 |
| A | ASP315 |
| A | HIS374 |
| A | PW2502 |
| A | HOH605 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue PW2 A 502 |
| Chain | Residue |
| A | TYR329 |
| A | LEU343 |
| A | HIS374 |
| A | VAL376 |
| A | ARG383 |
| A | MN501 |
| A | HOH605 |
| C | LYS400 |
| C | VAL401 |
| A | TYR303 |
| A | TYR310 |
| A | HIS313 |
| A | ASP315 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 501 |
| Chain | Residue |
| B | HIS313 |
| B | ASP315 |
| B | HIS374 |
| B | PW2502 |
| B | HOH607 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue PW2 B 502 |
| Chain | Residue |
| B | ILE251 |
| B | ARG252 |
| B | MET299 |
| B | TYR303 |
| B | HIS313 |
| B | TYR329 |
| B | LEU343 |
| B | HIS374 |
| B | VAL376 |
| B | ARG383 |
| B | MN501 |
| B | HOH601 |
| B | HOH607 |
| F | VAL401 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MN C 501 |
| Chain | Residue |
| C | HIS313 |
| C | ASP315 |
| C | HIS374 |
| C | PW2502 |
| C | HOH607 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue PW2 C 502 |
| Chain | Residue |
| C | MET299 |
| C | TYR303 |
| C | TYR310 |
| C | HIS313 |
| C | ILE327 |
| C | TYR329 |
| C | HIS374 |
| C | VAL376 |
| C | ARG383 |
| C | MN501 |
| C | HOH607 |
| D | VAL401 |
| D | LEU404 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue MN D 501 |
| Chain | Residue |
| D | HIS313 |
| D | ASP315 |
| D | HIS374 |
| D | PW2502 |
| D | HOH606 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | binding site for residue PW2 D 502 |
| Chain | Residue |
| A | LYS400 |
| A | VAL401 |
| D | ASP250 |
| D | ARG252 |
| D | MET299 |
| D | TYR303 |
| D | TYR310 |
| D | HIS313 |
| D | TYR329 |
| D | LEU343 |
| D | HIS374 |
| D | VAL376 |
| D | ARG383 |
| D | MN501 |
| D | HOH606 |
| D | HOH607 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue MN E 501 |
| Chain | Residue |
| E | HIS313 |
| E | ASP315 |
| E | HIS374 |
| E | PW2502 |
| E | HOH609 |
| site_id | AD1 |
| Number of Residues | 12 |
| Details | binding site for residue PW2 E 502 |
| Chain | Residue |
| B | VAL401 |
| E | MET299 |
| E | TYR303 |
| E | HIS313 |
| E | TYR329 |
| E | LEU343 |
| E | HIS374 |
| E | VAL376 |
| E | ARG383 |
| E | MN501 |
| E | HOH605 |
| E | HOH609 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue GOL E 503 |
| Chain | Residue |
| E | VAL210 |
| E | ASP211 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 E 504 |
| Chain | Residue |
| E | ASP355 |
| E | GLU357 |
| E | LYS359 |
| E | ARG362 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue MN F 501 |
| Chain | Residue |
| F | HIS313 |
| F | ASP315 |
| F | HIS374 |
| F | PW2502 |
| F | HOH605 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for residue PW2 F 502 |
| Chain | Residue |
| E | LYS400 |
| F | TYR303 |
| F | HIS313 |
| F | TYR329 |
| F | LEU343 |
| F | HIS374 |
| F | VAL376 |
| F | ARG383 |
| F | MN501 |
| F | HOH605 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16782814, ECO:0000269|PubMed:19604478, ECO:0000269|PubMed:28594552, ECO:0007744|PDB:2G19, ECO:0007744|PDB:3HQU, ECO:0007744|PDB:5V18 |
| Chain | Residue | Details |
| B | HIS313 | |
| B | ASP315 | |
| B | HIS374 | |
| C | HIS313 | |
| C | ASP315 | |
| C | HIS374 | |
| D | HIS313 | |
| D | ASP315 | |
| D | HIS374 | |
| E | HIS313 | |
| E | ASP315 | |
| E | HIS374 | |
| F | HIS313 | |
| F | ASP315 | |
| F | HIS374 | |
| A | HIS313 | |
| A | ASP315 | |
| A | HIS374 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:19604478 |
| Chain | Residue | Details |
| B | ARG383 | |
| C | ARG383 | |
| D | ARG383 | |
| E | ARG383 | |
| F | ARG383 | |
| A | ARG383 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:21601578 |
| Chain | Residue | Details |
| B | CYS201 | |
| B | CYS208 | |
| B | CYS302 | |
| B | CYS323 | |
| B | CYS326 | |
| C | CYS201 | |
| C | CYS208 | |
| C | CYS302 | |
| C | CYS323 | |
| C | CYS326 | |
| D | CYS201 | |
| D | CYS208 | |
| D | CYS302 | |
| D | CYS323 | |
| D | CYS326 | |
| E | CYS201 | |
| E | CYS208 | |
| E | CYS302 | |
| E | CYS323 | |
| E | CYS326 | |
| F | CYS201 | |
| F | CYS208 | |
| F | CYS302 | |
| F | CYS323 | |
| F | CYS326 | |
| A | CYS201 | |
| A | CYS208 | |
| A | CYS302 | |
| A | CYS323 | |
| A | CYS326 |
