6YVT

HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with MD-253

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0031418	molecular_function	L-ascorbic acid binding
B	0005506	molecular_function	iron ion binding
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0031418	molecular_function	L-ascorbic acid binding
C	0005506	molecular_function	iron ion binding
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0031418	molecular_function	L-ascorbic acid binding
D	0005506	molecular_function	iron ion binding
D	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D	0031418	molecular_function	L-ascorbic acid binding
E	0005506	molecular_function	iron ion binding
E	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
E	0031418	molecular_function	L-ascorbic acid binding
F	0005506	molecular_function	iron ion binding
F	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
F	0031418	molecular_function	L-ascorbic acid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MN A 501

Chain	Residue
A	HIS313
A	ASP315
A	HIS374
A	PW2502
A	HOH605

---

site_id	AC2
Number of Residues	13
Details	binding site for residue PW2 A 502

Chain	Residue
A	TYR329
A	LEU343
A	HIS374
A	VAL376
A	ARG383
A	MN501
A	HOH605
C	LYS400
C	VAL401
A	TYR303
A	TYR310
A	HIS313
A	ASP315

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MN B 501

Chain	Residue
B	HIS313
B	ASP315
B	HIS374
B	PW2502
B	HOH607

---

site_id	AC4
Number of Residues	14
Details	binding site for residue PW2 B 502

Chain	Residue
B	ILE251
B	ARG252
B	MET299
B	TYR303
B	HIS313
B	TYR329
B	LEU343
B	HIS374
B	VAL376
B	ARG383
B	MN501
B	HOH601
B	HOH607
F	VAL401

---

site_id	AC5
Number of Residues	5
Details	binding site for residue MN C 501

Chain	Residue
C	HIS313
C	ASP315
C	HIS374
C	PW2502
C	HOH607

---

site_id	AC6
Number of Residues	13
Details	binding site for residue PW2 C 502

Chain	Residue
C	MET299
C	TYR303
C	TYR310
C	HIS313
C	ILE327
C	TYR329
C	HIS374
C	VAL376
C	ARG383
C	MN501
C	HOH607
D	VAL401
D	LEU404

---

site_id	AC7
Number of Residues	5
Details	binding site for residue MN D 501

Chain	Residue
D	HIS313
D	ASP315
D	HIS374
D	PW2502
D	HOH606

---

site_id	AC8
Number of Residues	16
Details	binding site for residue PW2 D 502

Chain	Residue
A	LYS400
A	VAL401
D	ASP250
D	ARG252
D	MET299
D	TYR303
D	TYR310
D	HIS313
D	TYR329
D	LEU343
D	HIS374
D	VAL376
D	ARG383
D	MN501
D	HOH606
D	HOH607

---

site_id	AC9
Number of Residues	5
Details	binding site for residue MN E 501

Chain	Residue
E	HIS313
E	ASP315
E	HIS374
E	PW2502
E	HOH609

---

site_id	AD1
Number of Residues	12
Details	binding site for residue PW2 E 502

Chain	Residue
B	VAL401
E	MET299
E	TYR303
E	HIS313
E	TYR329
E	LEU343
E	HIS374
E	VAL376
E	ARG383
E	MN501
E	HOH605
E	HOH609

---

site_id	AD2
Number of Residues	2
Details	binding site for residue GOL E 503

Chain	Residue
E	VAL210
E	ASP211

---

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 E 504

Chain	Residue
E	ASP355
E	GLU357
E	LYS359
E	ARG362

---

site_id	AD4
Number of Residues	5
Details	binding site for residue MN F 501

Chain	Residue
F	HIS313
F	ASP315
F	HIS374
F	PW2502
F	HOH605

---

site_id	AD5
Number of Residues	10
Details	binding site for residue PW2 F 502

Chain	Residue
E	LYS400
F	TYR303
F	HIS313
F	TYR329
F	LEU343
F	HIS374
F	VAL376
F	ARG383
F	MN501
F	HOH605

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	606
Details	Domain: {"description":"Fe2OG dioxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16782814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28594552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2G19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V18","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	30
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"21601578","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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