8K5W

Crystal structure of human proMMP-9 catalytic domain in complex with inhibitor

Summary for 8K5W

Entry DOI	10.2210/pdb8k5w/pdb
Descriptor	Matrix metalloproteinase-9, ZINC ION, CALCIUM ION, ... (6 entities in total)
Functional Keywords	mmp-9, 92 kda gelatinase, 92 kda type iv collagenase, gelatinase b, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	55869.16
Authors	Kamitani, M.,Mima, M.,Nishikawa-Shimono, R. (deposition date: 2023-07-24, release date: 2023-12-06)
Primary citation	Nishikawa-Shimono, R.,Kuwabara, M.,Fujisaki, S.,Matsuda, D.,Endo, M.,Kamitani, M.,Futamura, A.,Nomura, Y.,Yamaguchi-Sasaki, T.,Yabuuchi, T.,Yamaguchi, C.,Tanaka-Yamamoto, N.,Satake, S.,Abe-Sato, K.,Funayama, K.,Sakata, M.,Takahashi, S.,Hirano, K.,Fukunaga, T.,Uozumi, Y.,Kato, S.,Tamura, Y.,Nakamori, T.,Mima, M.,Mishima-Tsumagari, C.,Nozawa, D.,Imai, Y.,Asami, T. Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation. Bioorg.Med.Chem.Lett., 97:129541-129541, 2023 Cited by PubMed: 37952596 DOI: 10.1016/j.bmcl.2023.129541 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation