8K5W
Crystal structure of human proMMP-9 catalytic domain in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Matrix metalloproteinase-9 | polymer | 242 | 27175.5 | 2 | UniProt (P14780) Pfam (PF00413) | Homo sapiens (human) | MMP-9,92 kDa gelatinase,92 kDa type IV collagenase,Gelatinase B,GELB |
| 2 | C, D, I, J (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | E, F, G, K, L... (A, B) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 4 | H, N (A, B) | 2-[[5-fluoranyl-7-(methylamino)-1H-indol-2-yl]carbonyl]-N-(2-pyrrol-1-ylethyl)-3,4-dihydro-1H-isoquinoline-7-carboxamide | non-polymer | 459.5 | 2 | Chemie (VOO) | |||
| 5 | O (B) | DIHYDROGENPHOSPHATE ION | non-polymer | 97.0 | 1 | Chemie (2HP) | |||
| 6 | P, Q (A, B) | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A, B: 29 - 215 (UniProt: P14780)
A, B: 216 - 269 (UniProt: P14780)
| PDB | External Database | Details |
|---|---|---|
| Met 28 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54351.0 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1518.1 | |
| All* | Total formula weight | 55869.2 |
