5J2Y
 
 | | Molecular insight into the regulatory mechanism of the quorum-sensing repressor RsaL in Pseudomonas aeruginosa | | Descriptor: | DNA (26-MER), Regulatory protein | | Authors: | Zhao, J, Gan, J, Zhang, J, Kang, H, Kong, W, Zhu, M, Li, F, Song, Y, Qin, J, Liang, H. | | Deposit date: | 2016-03-30 | | Release date: | 2017-04-12 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of Pseudomonas aeruginosa RsaL bound to promoter DNA reaffirms its role as a global regulator involved in quorum-sensing.
Nucleic Acids Res., 45, 2017
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1CQG
 | | HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN REF-1 (RESIDUES 59-71 OF THE P50 SUBUNIT OF NFKB), NMR, 31 STRUCTURES | | Descriptor: | REF-1 PEPTIDE, THIOREDOXIN | | Authors: | Clore, G.M, Qin, J, Gronenborn, A.M. | | Deposit date: | 1996-04-02 | | Release date: | 1996-08-01 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal.
Structure, 4, 1996
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1CQH
 | | HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN REF-1 (RESIDUES 59-71 OF THE P50 SUBUNIT OF NFKB), NMR, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | REF-1 PEPTIDE, THIOREDOXIN | | Authors: | Clore, G.M, Qin, J, Gronenborn, A.M. | | Deposit date: | 1996-04-02 | | Release date: | 1996-08-01 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal.
Structure, 4, 1996
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3ISW
 | | Crystal structure of filamin-A immunoglobulin-like repeat 21 bound to an N-terminal peptide of CFTR | | Descriptor: | Cystic fibrosis transmembrane conductance regulator, Filamin-A | | Authors: | Xu, Z, Page, R, Qin, J, Ithychanda, S.S, Liu, J.M, Misra, S. | | Deposit date: | 2009-08-27 | | Release date: | 2010-04-07 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Biochemical basis of the interaction between cystic fibrosis transmembrane conductance regulator and immunoglobulin-like repeats of filamin.
J.Biol.Chem., 285, 2010
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6MIB
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6BA6
 | | Solution structure of Rap1b/talin complex | | Descriptor: | Ras-related protein Rap-1b, Talin-1 | | Authors: | Zhu, L, Yang, J, Qin, J. | | Deposit date: | 2017-10-12 | | Release date: | 2017-12-06 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation.
Nat Commun, 8, 2017
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4RLP
 | | Human p70s6k1 with ruthenium-based inhibitor FL772 | | Descriptor: | CHLORIDE ION, [(amino-kappaN)methanethiolato](3-fluoro-9-methoxypyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dionato-kappa~2~N,N')(N-methyl-1,4,7-trithiecan-9-amine-kappa~3~S~1~,S~4~,S~7~)ruthenium, p70S6K1 | | Authors: | Domsic, J.F, Barber-Rotenberg, J, Salami, J, Qin, J, Marmorstein, R. | | Deposit date: | 2014-10-17 | | Release date: | 2015-01-21 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | Development of Organometallic S6K1 Inhibitors.
J.Med.Chem., 58, 2015
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4RLO
 | | Human p70s6k1 with ruthenium-based inhibitor EM5 | | Descriptor: | CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | | Authors: | Domsic, J.F, Barber-Rotenberg, J, Salami, J, Qin, J, Marmorstein, R. | | Deposit date: | 2014-10-17 | | Release date: | 2015-01-21 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.527 Å) | | Cite: | Development of Organometallic S6K1 Inhibitors.
J.Med.Chem., 58, 2015
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3CWG
 | | Unphosphorylated mouse STAT3 core fragment | | Descriptor: | Signal transducer and activator of transcription 3 | | Authors: | Ren, Z, Mao, X, Mertens, C, Krishnaraj, R, Qin, J, Mandal, P.K, Romanowshi, M.J, McMurray, J.S. | | Deposit date: | 2008-04-21 | | Release date: | 2008-07-01 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Crystal structure of unphosphorylated STAT3 core fragment.
Biochem.Biophys.Res.Commun., 374, 2008
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7XW9
 | | Cryo-EM structure of the TRH-bound human TRHR-Gq complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | | Authors: | Ji, S, Dong, Y, Chen, L, Zang, S, Shen, D, Guo, J, Qin, J, Zhang, H, Wang, W, Shen, Q, Mao, C, Zhang, Y. | | Deposit date: | 2022-05-26 | | Release date: | 2022-12-28 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Molecular basis for the activation of thyrotropin-releasing hormone receptor.
Cell Discov, 8, 2022
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4F7G
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2LGX
 | | NMR structure for Kindle-2 N-terminus | | Descriptor: | Fermitin family homolog 2 | | Authors: | Perera, H.D, Ma, Y, Yang, J, Hirbawi, J, Plow, E.F, Qin, J. | | Deposit date: | 2011-08-03 | | Release date: | 2011-11-30 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Membrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin Activation.
Structure, 19, 2011
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2G35
 | | NMR structure of talin-PTB in complex with PIPKI | | Descriptor: | Talin-1, peptide | | Authors: | Kong, X, Wang, X, Misra, S, Qin, J. | | Deposit date: | 2006-02-17 | | Release date: | 2006-05-02 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Structural Basis for the Phosphorylation-regulated Focal Adhesion Targeting of Type Igamma Phosphatidylinositol Phosphate Kinase (PIPKIgamma) by Talin.
J.Mol.Biol., 359, 2006
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1U5S
 | | NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain | | Descriptor: | Cytoplasmic protein NCK2, PINCH protein, ZINC ION | | Authors: | Vaynberg, J, Fukuda, T, Vinogradova, O, Velyvis, A, Ng, L, Wu, C, Qin, J. | | Deposit date: | 2004-07-28 | | Release date: | 2005-04-05 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility.
Mol.Cell, 17, 2005
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1S4W
 | | NMR structure of the cytoplasmic domain of integrin AIIb in DPC micelles | | Descriptor: | Integrin alpha-IIb | | Authors: | Vinogradova, O, Vaynberg, J, Kong, X, Haas, T.A, Plow, E.F, Qin, J. | | Deposit date: | 2004-01-19 | | Release date: | 2004-03-09 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Membrane-mediated structural transitions at the cytoplasmic face during integrin activation.
Proc.Natl.Acad.Sci.USA, 101, 2004
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1S4X
 | | NMR Structure of the integrin B3 cytoplasmic domain in DPC micelles | | Descriptor: | Integrin beta-3 | | Authors: | Vinogradova, O, Vaynberg, J, Kong, X, Haas, T.A, Plow, E.F, Qin, J. | | Deposit date: | 2004-01-19 | | Release date: | 2004-03-09 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Membrane-mediated structural transitions at the cytoplasmic face during integrin activation.
Proc.Natl.Acad.Sci.USA, 101, 2004
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2K2R
 | | The NMR structure of alpha-parvin CH2/paxillin LD1 complex | | Descriptor: | Alpha-parvin, Paxillin | | Authors: | Wang, X, Fukuda, K, Byeon, I, Velyvis, A, Wu, C, Gronenborn, A, Qin, J. | | Deposit date: | 2008-04-10 | | Release date: | 2008-05-27 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | The Structure of {alpha}-Parvin CH2-Paxillin LD1 Complex Reveals a Novel Modular Recognition for Focal Adhesion Assembly.
J.Biol.Chem., 283, 2008
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1B4Q
 | | Solution structure of human thioltransferase complex with glutathione | | Descriptor: | GLUTATHIONE, PROTEIN (HUMAN THIOLTRANSFERASE) | | Authors: | Yang, Y, Jao, S.C, Nanduri, S, Starke, D.W, Mieyal, J.J, Qin, J. | | Deposit date: | 1998-12-25 | | Release date: | 1999-12-23 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Reactivity of the human thioltransferase (glutaredoxin) C7S, C25S, C78S, C82S mutant and NMR solution structure of its glutathionyl mixed disulfide intermediate reflect catalytic specificity.
Biochemistry, 37, 1998
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7LT9
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7LT8
 | | Crystal structure of Ras suppressor-1 | | Descriptor: | Ras suppressor protein 1 | | Authors: | Fukuda, K, Qin, J. | | Deposit date: | 2021-02-19 | | Release date: | 2021-04-28 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.76000249 Å) | | Cite: | Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly.
J.Biol.Chem., 296, 2021
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2KNC
 | | Platelet integrin ALFAIIB-BETA3 transmembrane-cytoplasmic heterocomplex | | Descriptor: | Integrin alpha-IIb, Integrin beta-3 | | Authors: | Yang, J, Ma, Y, Page, R.C, Misra, S, Plow, E.F, Qin, J. | | Deposit date: | 2009-08-20 | | Release date: | 2009-09-29 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | Structure of an integrin alphaIIb beta3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation.
Proc.Natl.Acad.Sci.USA, 106, 2009
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1DPQ
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1G47
 | | 1ST LIM DOMAIN OF PINCH PROTEIN | | Descriptor: | PINCH PROTEIN, ZINC ION | | Authors: | Velyvis, A, Yang, Y, Wu, C, Qin, J. | | Deposit date: | 2000-10-26 | | Release date: | 2001-02-21 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain.
J.Biol.Chem., 276, 2001
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1DPK
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2MWN
 | | Talin-F3 / RIAM N-terminal Peptide complex | | Descriptor: | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein, Talin-1 | | Authors: | Yang, J, Zhu, L, Zhang, H, Hirbawi, J, Fukuda, K, Dwivedi, P, Liu, J, Byzova, T, Plow, E.F, Wu, J, Qin, J. | | Deposit date: | 2014-11-13 | | Release date: | 2014-12-17 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion.
Nat Commun, 5, 2014
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