3ISW
Crystal structure of filamin-A immunoglobulin-like repeat 21 bound to an N-terminal peptide of CFTR
Summary for 3ISW
Entry DOI | 10.2210/pdb3isw/pdb |
Descriptor | Filamin-A, Cystic fibrosis transmembrane conductance regulator (3 entities in total) |
Functional Keywords | protein-peptide complex, acetylation, actin-binding, alternative splicing, cytoplasm, cytoskeleton, disease mutation, phosphoprotein, polymorphism, atp-binding, chloride, chloride channel, glycoprotein, hydrolase, ion transport, ionic channel, membrane, nucleotide-binding, transmembrane, transport, structural protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm, cell cortex: P21333 Early endosome membrane; Multi-pass membrane protein: P13569 |
Total number of polymer chains | 3 |
Total formula weight | 22363.74 |
Authors | |
Primary citation | Smith, L.,Page, R.C.,Xu, Z.,Kohli, E.,Litman, P.,Nix, J.C.,Ithychanda, S.S.,Liu, J.,Qin, J.,Misra, S.,Liedtke, C.M. Biochemical basis of the interaction between cystic fibrosis transmembrane conductance regulator and immunoglobulin-like repeats of filamin. J.Biol.Chem., 285:17166-17176, 2010 Cited by PubMed: 20351101DOI: 10.1074/jbc.M109.080911 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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