3ISW

Crystal structure of filamin-A immunoglobulin-like repeat 21 bound to an N-terminal peptide of CFTR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Filamin-A	polymer	99	10177.2	2	UniProt (P21333) Pfam (PF00630)	Homo sapiens (human)	Alpha-filamin, Filamin-1, Endothelial actin-binding protein, Actin-binding protein 280, ABP-280, Non-muscle filamin
2	C (C)	Cystic fibrosis transmembrane conductance regulator	polymer	18	2009.3	1	UniProt (P13569)		CFTR, Channel conductance-controlling ATPase, cAMP-dependent chloride channel, ATP-binding cassette transporter sub-family C member 7
3	D, E, F (A, B, C)	water	water		18.0	14	Chemie (HOH)

Sequence modifications

A, B: 2236 - 2329 (UniProt: P21333)

PDB	External Database	Details
Gly 2231	-	expression tag
Ala 2232	-	expression tag
Met 2233	-	expression tag
Pro 2234	-	expression tag
Asp 2235	-	expression tag

C: 5 - 22 (UniProt: P13569)

PDB	External Database	Details
Ala 21	Arg 21	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	22363.7
All*	Total formula weight	22363.7

*Water molecules are not included.