7SC4
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![BU of 7sc4 by Molmil](/molmil-images/mine/7sc4) | filamin complex-1 | Descriptor: | Filamin-A/Integrin alpha-IIb light chain, form 2 chimera, SULFATE ION | Authors: | Liu, J, Qin, J. | Deposit date: | 2021-09-27 | Release date: | 2023-04-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A mechanism of platelet integrin alpha IIb beta 3 outside-in signaling through a novel integrin alpha IIb subunit-filamin-actin linkage. Blood, 141, 2023
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8ID6
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![BU of 8id6 by Molmil](/molmil-images/mine/8id6) | Cryo-EM structure of the oleic acid bound GPR120-Gi complex | Descriptor: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID9
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![BU of 8id9 by Molmil](/molmil-images/mine/8id9) | Cryo-EM structure of the eicosapentaenoic acid bound GPR120-Gi complex | Descriptor: | 5,8,11,14,17-EICOSAPENTAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID4
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![BU of 8id4 by Molmil](/molmil-images/mine/8id4) | Cryo-EM structure of the linoleic acid bound GPR120-Gi complex | Descriptor: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID3
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![BU of 8id3 by Molmil](/molmil-images/mine/8id3) | Cryo-EM structure of the 9-hydroxystearic acid bound GPR120-Gi complex | Descriptor: | 9-Hydroxyoctadecanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID8
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![BU of 8id8 by Molmil](/molmil-images/mine/8id8) | Cryo-EM structure of the TUG891 bound GPR120-Gi complex | Descriptor: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | Deposit date: | 2023-02-12 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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6U4M
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![BU of 6u4m by Molmil](/molmil-images/mine/6u4m) | Solution structure of paxillin LIM4 | Descriptor: | Paxillin, ZINC ION | Authors: | Zhu, L, Qin, J. | Deposit date: | 2019-08-26 | Release date: | 2019-10-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion. Structure, 27, 2019
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5J2Y
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![BU of 5j2y by Molmil](/molmil-images/mine/5j2y) | Molecular insight into the regulatory mechanism of the quorum-sensing repressor RsaL in Pseudomonas aeruginosa | Descriptor: | DNA (26-MER), Regulatory protein | Authors: | Zhao, J, Gan, J, Zhang, J, Kang, H, Kong, W, Zhu, M, Li, F, Song, Y, Qin, J, Liang, H. | Deposit date: | 2016-03-30 | Release date: | 2017-04-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of Pseudomonas aeruginosa RsaL bound to promoter DNA reaffirms its role as a global regulator involved in quorum-sensing. Nucleic Acids Res., 45, 2017
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1CQH
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![BU of 1cqh by Molmil](/molmil-images/mine/1cqh) | HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN REF-1 (RESIDUES 59-71 OF THE P50 SUBUNIT OF NFKB), NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | REF-1 PEPTIDE, THIOREDOXIN | Authors: | Clore, G.M, Qin, J, Gronenborn, A.M. | Deposit date: | 1996-04-02 | Release date: | 1996-08-01 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal. Structure, 4, 1996
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1CQG
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![BU of 1cqg by Molmil](/molmil-images/mine/1cqg) | HIGH RESOLUTION SOLUTION NMR STRUCTURE OF MIXED DISULFIDE INTERMEDIATE BETWEEN HUMAN THIOREDOXIN (C35A, C62A, C69A, C73A) MUTANT AND A 13 RESIDUE PEPTIDE COMPRISING ITS TARGET SITE IN HUMAN REF-1 (RESIDUES 59-71 OF THE P50 SUBUNIT OF NFKB), NMR, 31 STRUCTURES | Descriptor: | REF-1 PEPTIDE, THIOREDOXIN | Authors: | Clore, G.M, Qin, J, Gronenborn, A.M. | Deposit date: | 1996-04-02 | Release date: | 1996-08-01 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal. Structure, 4, 1996
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1G47
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![BU of 1g47 by Molmil](/molmil-images/mine/1g47) | 1ST LIM DOMAIN OF PINCH PROTEIN | Descriptor: | PINCH PROTEIN, ZINC ION | Authors: | Velyvis, A, Yang, Y, Wu, C, Qin, J. | Deposit date: | 2000-10-26 | Release date: | 2001-02-21 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. J.Biol.Chem., 276, 2001
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6MIB
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![BU of 6mib by Molmil](/molmil-images/mine/6mib) | |
3ISW
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![BU of 3isw by Molmil](/molmil-images/mine/3isw) | Crystal structure of filamin-A immunoglobulin-like repeat 21 bound to an N-terminal peptide of CFTR | Descriptor: | Cystic fibrosis transmembrane conductance regulator, Filamin-A | Authors: | Xu, Z, Page, R, Qin, J, Ithychanda, S.S, Liu, J.M, Misra, S. | Deposit date: | 2009-08-27 | Release date: | 2010-04-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Biochemical basis of the interaction between cystic fibrosis transmembrane conductance regulator and immunoglobulin-like repeats of filamin. J.Biol.Chem., 285, 2010
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4F7G
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![BU of 4f7g by Molmil](/molmil-images/mine/4f7g) | |
1MYO
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![BU of 1myo by Molmil](/molmil-images/mine/1myo) | SOLUTION STRUCTURE OF MYOTROPHIN, NMR, 44 STRUCTURES | Descriptor: | MYOTROPHIN | Authors: | Yang, Y, Nanduri, S, Sen, S, Qin, J. | Deposit date: | 1998-08-17 | Release date: | 1999-08-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The structural basis of ankyrin-like repeat function as revealed by the solution structure of myotrophin. Structure, 6, 1998
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6BA6
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![BU of 6ba6 by Molmil](/molmil-images/mine/6ba6) | Solution structure of Rap1b/talin complex | Descriptor: | Ras-related protein Rap-1b, Talin-1 | Authors: | Zhu, L, Yang, J, Qin, J. | Deposit date: | 2017-10-12 | Release date: | 2017-12-06 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation. Nat Commun, 8, 2017
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2MWN
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![BU of 2mwn by Molmil](/molmil-images/mine/2mwn) | Talin-F3 / RIAM N-terminal Peptide complex | Descriptor: | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein, Talin-1 | Authors: | Yang, J, Zhu, L, Zhang, H, Hirbawi, J, Fukuda, K, Dwivedi, P, Liu, J, Byzova, T, Plow, E.F, Wu, J, Qin, J. | Deposit date: | 2014-11-13 | Release date: | 2014-12-17 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion. Nat Commun, 5, 2014
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1NYP
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![BU of 1nyp by Molmil](/molmil-images/mine/1nyp) | 4th LIM domain of PINCH protein | Descriptor: | PINCH protein, ZINC ION | Authors: | Velyvis, A, Vaynberg, J, Vinogradova, O, Zhang, Y, Wu, C, Qin, J. | Deposit date: | 2003-02-13 | Release date: | 2003-07-01 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling Nat.Struct.Biol., 10, 2003
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2MTP
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![BU of 2mtp by Molmil](/molmil-images/mine/2mtp) | |
1QU6
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![BU of 1qu6 by Molmil](/molmil-images/mine/1qu6) | STRUCTURE OF THE DOUBLE-STRANDED RNA-BINDING DOMAIN OF THE PROTEIN KINASE PKR REVEALS THE MOLECULAR BASIS OF ITS DSRNA-MEDIATED ACTIVATION | Descriptor: | PROTEIN KINASE PKR | Authors: | Nanduri, S, Carpick, B.W, Yang, Y, Williams, B.R.G, Qin, J. | Deposit date: | 1999-07-08 | Release date: | 1999-12-23 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation. EMBO J., 17, 1998
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3KMU
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![BU of 3kmu by Molmil](/molmil-images/mine/3kmu) | |
3KMW
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![BU of 3kmw by Molmil](/molmil-images/mine/3kmw) | Crystal structure of the ILK/alpha-parvin core complex (MgATP) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Alpha-parvin, Integrin-linked kinase, ... | Authors: | Fukuda, K, Qin, J. | Deposit date: | 2009-11-11 | Release date: | 2009-12-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions. Mol.Cell, 36, 2009
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2MYO
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![BU of 2myo by Molmil](/molmil-images/mine/2myo) | SOLUTION STRUCTURE OF MYOTROPHIN, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | MYOTROPHIN | Authors: | Yang, Y, Nanduri, S, Sen, S, Qin, J. | Deposit date: | 1998-08-17 | Release date: | 1999-08-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The structural basis of ankyrin-like repeat function as revealed by the solution structure of myotrophin. Structure, 6, 1998
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2LGX
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![BU of 2lgx by Molmil](/molmil-images/mine/2lgx) | NMR structure for Kindle-2 N-terminus | Descriptor: | Fermitin family homolog 2 | Authors: | Perera, H.D, Ma, Y, Yang, J, Hirbawi, J, Plow, E.F, Qin, J. | Deposit date: | 2011-08-03 | Release date: | 2011-11-30 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Membrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin Activation. Structure, 19, 2011
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2KNC
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![BU of 2knc by Molmil](/molmil-images/mine/2knc) | Platelet integrin ALFAIIB-BETA3 transmembrane-cytoplasmic heterocomplex | Descriptor: | Integrin alpha-IIb, Integrin beta-3 | Authors: | Yang, J, Ma, Y, Page, R.C, Misra, S, Plow, E.F, Qin, J. | Deposit date: | 2009-08-20 | Release date: | 2009-09-29 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Structure of an integrin alphaIIb beta3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation. Proc.Natl.Acad.Sci.USA, 106, 2009
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