1WO2
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![BU of 1wo2 by Molmil](/molmil-images/mine/1wo2) | Crystal structure of the pig pancreatic alpha-amylase complexed with malto-oligosaacharides under the effect of the chloride ion | Descriptor: | 1,2-ETHANEDIOL, Alpha-amylase, pancreatic, ... | Authors: | Qian, M, Payan, F, Nahoum, V. | Deposit date: | 2004-08-11 | Release date: | 2005-03-15 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Molecular Basis of the Effects of Chloride Ion on the Acid-Base Catalyst in the Mechanism of Pancreatic alpha-Amylase Biochemistry, 44, 2005
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1PPI
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![BU of 1ppi by Molmil](/molmil-images/mine/1ppi) | THE ACTIVE CENTER OF A MAMMALIAN ALPHA-AMYLASE. THE STRUCTURE OF THE COMPLEX OF A PANCREATIC ALPHA-AMYLASE WITH A CARBOHYDRATE INHIBITOR REFINED TO 2.2 ANGSTROMS RESOLUTION | Descriptor: | 4,6-dideoxy-4-{[(1S,5R,6S)-3-formyl-5,6-dihydroxy-4-oxocyclohex-2-en-1-yl]amino}-alpha-D-xylo-hex-5-enopyranose-(1-4)-beta-D-glucopyranose, ALPHA-AMYLASE, CALCIUM ION, ... | Authors: | Qian, M, Haser, R, Payan, F. | Deposit date: | 1994-02-22 | Release date: | 1995-05-24 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The active center of a mammalian alpha-amylase. Structure of the complex of a pancreatic alpha-amylase with a carbohydrate inhibitor refined to 2.2-A resolution. Biochemistry, 33, 1994
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1JFH
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1HX0
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![BU of 1hx0 by Molmil](/molmil-images/mine/1hx0) | Structure of pig pancreatic alpha-amylase complexed with the "truncate" acarbose molecule (pseudotrisaccharide) | Descriptor: | 1,2-ETHANEDIOL, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ALPHA AMYLASE (PPA), ... | Authors: | Qian, M, Payan, F. | Deposit date: | 2001-01-11 | Release date: | 2001-08-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Enzyme-catalyzed condensation reaction in a mammalian alpha-amylase. High-resolution structural analysis of an enzyme-inhibitor complex Biochemistry, 40, 2001
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3TKK
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![BU of 3tkk by Molmil](/molmil-images/mine/3tkk) | Crystal Structure Analysis of a recombinant predicted acetamidase/ formamidase from the thermophile thermoanaerobacter tengcongensis | Descriptor: | CALCIUM ION, Predicted acetamidase/formamidase, ZINC ION | Authors: | Qian, M, Huang, Q, Wu, G, Lai, L, Tang, Y, Pei, J, Kusunoki, M. | Deposit date: | 2011-08-26 | Release date: | 2011-11-16 | Last modified: | 2012-02-08 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Crystal Structure Analysis of a Recombinant Predicted Acetamidase/Formamidase from the Thermophile Thermoanaerobacter tengcongensis. PROTEIN J., 31, 2012
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1LYO
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![BU of 1lyo by Molmil](/molmil-images/mine/1lyo) | CROSS-LINKED LYSOZYME CRYSTAL IN NEAT WATER | Descriptor: | LYSOZYME | Authors: | Huang, Q, Wang, Z, Zhu, G, Qian, M, Shao, M, Jia, Y, Tang, Y. | Deposit date: | 1998-03-05 | Release date: | 1998-05-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixture. Biochim.Biophys.Acta, 1384, 1998
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3LYO
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![BU of 3lyo by Molmil](/molmil-images/mine/3lyo) | CROSS-LINKED CHICKEN LYSOZYME CRYSTAL IN 95% ACETONITRILE-WATER | Descriptor: | ACETONITRILE, LYSOZYME | Authors: | Huang, Q, Wang, Z, Zhu, G, Qian, M, Shao, M, Jia, Y, Tang, Y. | Deposit date: | 1998-03-11 | Release date: | 1998-05-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixture. Biochim.Biophys.Acta, 1384, 1998
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6RVC
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![BU of 6rvc by Molmil](/molmil-images/mine/6rvc) | Crystal structure of Patched-1 ectodomain 2 (PTCH1-ECD2) in complex with nanobody 75 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody NB75, Protein patched homolog 1, ... | Authors: | Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C. | Deposit date: | 2019-05-31 | Release date: | 2019-10-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nat.Chem.Biol., 15, 2019
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6RTW
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![BU of 6rtw by Molmil](/molmil-images/mine/6rtw) | Crystal structure of the Patched-1 (PTCH1) ectodomain in complex with nanobody NB64 and cholesterol-hemisuccinate | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Llama-derived nanobody NB64, ... | Authors: | Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C. | Deposit date: | 2019-05-27 | Release date: | 2019-10-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nat.Chem.Biol., 15, 2019
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6RTX
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![BU of 6rtx by Molmil](/molmil-images/mine/6rtx) | Crystal structure of the Patched-1 (PTCH1) ectodomain 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1 | Authors: | Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C. | Deposit date: | 2019-05-27 | Release date: | 2019-10-02 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nat.Chem.Biol., 15, 2019
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6RVD
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![BU of 6rvd by Molmil](/molmil-images/mine/6rvd) | Revised cryo-EM structure of the human 2:1 Ptch1-Shh complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | El Omari, K, Rudolf, A.F, Kowatsch, C, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C. | Deposit date: | 2019-05-31 | Release date: | 2019-10-02 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nat.Chem.Biol., 15, 2019
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6RTY
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![BU of 6rty by Molmil](/molmil-images/mine/6rty) | Crystal structure of the Patched ectodomain in complex with nanobody NB64 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Llama-derived nanobody NB64, Protein patched homolog 1 | Authors: | Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C. | Deposit date: | 2019-05-27 | Release date: | 2019-10-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nat.Chem.Biol., 15, 2019
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7PGK
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![BU of 7pgk by Molmil](/molmil-images/mine/7pgk) | HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), in complex with glycosaminoglycan mimic SOS | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Hedgehog-interacting protein | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | Deposit date: | 2021-08-14 | Release date: | 2021-12-15 | Last modified: | 2021-12-22 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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2LYO
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![BU of 2lyo by Molmil](/molmil-images/mine/2lyo) | CROSS-LINKED CHICKEN LYSOZYME CRYSTAL IN 90% ACETONITRILE-WATER | Descriptor: | ACETONITRILE, LYSOZYME | Authors: | Huang, Q, Wang, Z, Zhu, G, Qian, M, Shao, M, Jia, Y, Tang, Y. | Deposit date: | 1998-03-06 | Release date: | 1998-05-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixture. Biochim.Biophys.Acta, 1384, 1998
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1VAH
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![BU of 1vah by Molmil](/molmil-images/mine/1vah) | Crystal structure of the pig pancreatic-amylase complexed with r-nitrophenyl-a-D-maltoside | Descriptor: | Alpha-amylase, pancreatic, CALCIUM ION, ... | Authors: | Zhuo, H, Payan, F, Qian, M. | Deposit date: | 2004-02-17 | Release date: | 2005-04-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the pig pancreatic alpha-amylase complexed with rho-nitrophenyl-alpha-D-maltoside-flexibility in the active site Protein J., 23, 2004
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7PGN
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![BU of 7pgn by Molmil](/molmil-images/mine/7pgn) | HHP-C in complex with glycosaminoglycan mimic SOS | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | Deposit date: | 2021-08-14 | Release date: | 2021-12-15 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGL
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![BU of 7pgl by Molmil](/molmil-images/mine/7pgl) | HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), apo-form | Descriptor: | Hedgehog-interacting protein | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | Deposit date: | 2021-08-14 | Release date: | 2021-12-15 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGM
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![BU of 7pgm by Molmil](/molmil-images/mine/7pgm) | HHIP-C in complex with heparin | Descriptor: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-3)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hedgehog-interacting protein | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | Deposit date: | 2021-08-14 | Release date: | 2021-12-15 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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4LYO
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![BU of 4lyo by Molmil](/molmil-images/mine/4lyo) | CROSS-LINKED CHICKEN LYSOZYME CRYSTAL IN NEAT ACETONITRILE, THEN BACK-SOAKED IN WATER | Descriptor: | LYSOZYME | Authors: | Huang, Q, Wang, Z, Zhu, G, Qian, M, Shao, M, Jia, Y, Tang, Y. | Deposit date: | 1998-03-11 | Release date: | 1998-05-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixture. Biochim.Biophys.Acta, 1384, 1998
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1F2S
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![BU of 1f2s by Molmil](/molmil-images/mine/1f2s) | CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN BOVINE BETA-TRYPSIN AND MCTI-A, A TRYPSIN INHIBITOR OF SQUASH FAMILY AT 1.8 A RESOLUTION | Descriptor: | CALCIUM ION, TRYPSIN, TRYPSIN INHIBITOR A | Authors: | Zhu, Y, Huang, Q, Qian, M, Jia, Y, Tang, Y. | Deposit date: | 2000-05-29 | Release date: | 2000-06-05 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Crystal structure of the complex formed between bovine beta-trypsin and MCTI-A, a trypsin inhibitor of squash family, at 1.8-A resolution. J.Protein Chem., 18, 1999
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1UA3
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![BU of 1ua3 by Molmil](/molmil-images/mine/1ua3) | |
1JW6
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![BU of 1jw6 by Molmil](/molmil-images/mine/1jw6) | Crystal Structure of the Complex of Concanavalin A and Hexapeptide | Descriptor: | CALCIUM ION, Concanavalin A, ISOPROPYL ALCOHOL, ... | Authors: | Zhang, Z, Qian, M, Huang, Q, Jia, Y, Tang, Y. | Deposit date: | 2001-09-02 | Release date: | 2001-09-26 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystal structure of the complex of concanavalin A and hexapeptide. J.Protein Chem., 20, 2001
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1F8Q
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![BU of 1f8q by Molmil](/molmil-images/mine/1f8q) | CRYSTAL STRUCTURE OF ALPHA-MOMORCHARIN IN ACETONITRILE-WATER MIXTURE | Descriptor: | ACETONITRILE, ALPHA-MOMORCHARIN, PENTANEDIAL, ... | Authors: | Zhu, G, Huang, Q, Qian, M, Tang, Y. | Deposit date: | 2000-07-03 | Release date: | 2000-07-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of alpha-momorcharin in 80% acetonitrile--water mixture BIOCHIM.BIOPHYS.ACTA, 1548, 2001
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1HQW
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![BU of 1hqw by Molmil](/molmil-images/mine/1hqw) | CRYSTAL STRUCTURE OF THE COMPLEX OF CONCANAVALIN A WITH A TRIPEPTIDE YPY | Descriptor: | CALCIUM ION, CONCANAVALIN A, MANGANESE (II) ION, ... | Authors: | Zhang, Z, Qian, M, Huang, Q, Jia, Y, Tang, Y, Wang, K, Cui, D, Li, M. | Deposit date: | 2000-12-20 | Release date: | 2003-10-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the complex of concanavalin A and tripeptide J.PROTEIN CHEM., 20, 2001
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1LZV
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![BU of 1lzv by Molmil](/molmil-images/mine/1lzv) | Site-Specific Mutant (Tyr7 replaced with His) of Human Carbonic Anhydrase II | Descriptor: | Carbonic Anhydrase II, ZINC ION | Authors: | Tu, C.K, Qian, M, An, H, Wadhwa, N.R, Duda, D.M, Yoshioka, C, Pathak, Y, McKenna, R, Laipis, P.J, Silverman, D.N. | Deposit date: | 2002-06-11 | Release date: | 2002-10-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase. J.Biol.Chem., 277, 2002
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